Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
