Interior Operators and Their Relationship to Autocatalytic Networks
Acta Biotheor. 2023 Oct 27;71(4):21. doi: 10.1007/s10441-023-09472-8.ABSTRACTThe emergence of an autocatalytic network from an available set of elements is a fundamental step in early evolutionary processes, such as the origin of metabolism. Given the set of elements, the reactions between them (chemical or otherwise), and with various elements catalysing certain reactions, a Reflexively Autocatalytic F-generated (RAF) set is a subset R[Formula: see text] of reactions that is self-generating from a given food set, and with each reaction in R[Formula: see text] being catalysed from within R[Formula: see text]. RAF theory ha...
Source: Acta Biotheoretica - October 27, 2023 Category: Biomedical Science Authors: Mike Steel Source Type: research
Interior Operators and Their Relationship to Autocatalytic Networks
Acta Biotheor. 2023 Oct 27;71(4):21. doi: 10.1007/s10441-023-09472-8.ABSTRACTThe emergence of an autocatalytic network from an available set of elements is a fundamental step in early evolutionary processes, such as the origin of metabolism. Given the set of elements, the reactions between them (chemical or otherwise), and with various elements catalysing certain reactions, a Reflexively Autocatalytic F-generated (RAF) set is a subset R[Formula: see text] of reactions that is self-generating from a given food set, and with each reaction in R[Formula: see text] being catalysed from within R[Formula: see text]. RAF theory ha...
Source: Acta Biotheoretica - October 27, 2023 Category: Biomedical Science Authors: Mike Steel Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
