The First Nucleic Acid Strands May Have Grown on Peptides via Primeval Reverse Translation
Acta Biotheor. 2023 Nov 10;71(4):23. doi: 10.1007/s10441-023-09474-6.ABSTRACTThe central dogma of molecular biology dictates that, with only a few exceptions, information proceeds from DNA to protein through an RNA intermediate. Examining the enigmatic steps from prebiotic to biological chemistry, we take another road suggesting that primordial peptides acted as template for the self-assembly of the first nucleic acids polymers. Arguing in favour of a sort of archaic "reverse translation" from proteins to RNA, our basic premise is a Hadean Earth where key biomolecules such as amino acids, polypeptides, purines, pyrimidines...
Source: Acta Biotheoretica - November 10, 2023 Category: Biomedical Science Authors: Arturo Tozzi Marco Mazzeo Source Type: research
The First Nucleic Acid Strands May Have Grown on Peptides via Primeval Reverse Translation
Acta Biotheor. 2023 Nov 10;71(4):23. doi: 10.1007/s10441-023-09474-6.ABSTRACTThe central dogma of molecular biology dictates that, with only a few exceptions, information proceeds from DNA to protein through an RNA intermediate. Examining the enigmatic steps from prebiotic to biological chemistry, we take another road suggesting that primordial peptides acted as template for the self-assembly of the first nucleic acids polymers. Arguing in favour of a sort of archaic "reverse translation" from proteins to RNA, our basic premise is a Hadean Earth where key biomolecules such as amino acids, polypeptides, purines, pyrimidines...
Source: Acta Biotheoretica - November 10, 2023 Category: Biomedical Science Authors: Arturo Tozzi Marco Mazzeo Source Type: research
The First Nucleic Acid Strands May Have Grown on Peptides via Primeval Reverse Translation
Acta Biotheor. 2023 Nov 10;71(4):23. doi: 10.1007/s10441-023-09474-6.ABSTRACTThe central dogma of molecular biology dictates that, with only a few exceptions, information proceeds from DNA to protein through an RNA intermediate. Examining the enigmatic steps from prebiotic to biological chemistry, we take another road suggesting that primordial peptides acted as template for the self-assembly of the first nucleic acids polymers. Arguing in favour of a sort of archaic "reverse translation" from proteins to RNA, our basic premise is a Hadean Earth where key biomolecules such as amino acids, polypeptides, purines, pyrimidines...
Source: Acta Biotheoretica - November 10, 2023 Category: Biomedical Science Authors: Arturo Tozzi Marco Mazzeo Source Type: research
The First Nucleic Acid Strands May Have Grown on Peptides via Primeval Reverse Translation
Acta Biotheor. 2023 Nov 10;71(4):23. doi: 10.1007/s10441-023-09474-6.ABSTRACTThe central dogma of molecular biology dictates that, with only a few exceptions, information proceeds from DNA to protein through an RNA intermediate. Examining the enigmatic steps from prebiotic to biological chemistry, we take another road suggesting that primordial peptides acted as template for the self-assembly of the first nucleic acids polymers. Arguing in favour of a sort of archaic "reverse translation" from proteins to RNA, our basic premise is a Hadean Earth where key biomolecules such as amino acids, polypeptides, purines, pyrimidines...
Source: Acta Biotheoretica - November 10, 2023 Category: Biomedical Science Authors: Arturo Tozzi Marco Mazzeo Source Type: research
The First Nucleic Acid Strands May Have Grown on Peptides via Primeval Reverse Translation
Acta Biotheor. 2023 Nov 10;71(4):23. doi: 10.1007/s10441-023-09474-6.ABSTRACTThe central dogma of molecular biology dictates that, with only a few exceptions, information proceeds from DNA to protein through an RNA intermediate. Examining the enigmatic steps from prebiotic to biological chemistry, we take another road suggesting that primordial peptides acted as template for the self-assembly of the first nucleic acids polymers. Arguing in favour of a sort of archaic "reverse translation" from proteins to RNA, our basic premise is a Hadean Earth where key biomolecules such as amino acids, polypeptides, purines, pyrimidines...
Source: Acta Biotheoretica - November 10, 2023 Category: Biomedical Science Authors: Arturo Tozzi Marco Mazzeo Source Type: research
On Pattern-Cladistic Analyses Based on Complete Plastid Genome Sequences
Acta Biotheor. 2023 Nov 3;71(4):22. doi: 10.1007/s10441-023-09475-5.ABSTRACTThe fundamental Hennigian principle, grouping solely on synapomorphy, is seldom used in modern phylogenetics. In the submitted paper, we apply this principle in reanalyzing five datasets comprising 197 complete plastid genomes (plastomes). We focused on the latter because plastome-based DNA sequence data gained dramatic popularity in molecular systematics during the last decade. We show that pattern-cladistic analyses based on complete plastid genome sequences can successfully resolve affinities between plant taxa, simultaneously simplifying both t...
Source: Acta Biotheoretica - November 3, 2023 Category: Biomedical Science Authors: Evgeny V Mavrodiev Alexander Madorsky Source Type: research
On Pattern-Cladistic Analyses Based on Complete Plastid Genome Sequences
Acta Biotheor. 2023 Nov 3;71(4):22. doi: 10.1007/s10441-023-09475-5.ABSTRACTThe fundamental Hennigian principle, grouping solely on synapomorphy, is seldom used in modern phylogenetics. In the submitted paper, we apply this principle in reanalyzing five datasets comprising 197 complete plastid genomes (plastomes). We focused on the latter because plastome-based DNA sequence data gained dramatic popularity in molecular systematics during the last decade. We show that pattern-cladistic analyses based on complete plastid genome sequences can successfully resolve affinities between plant taxa, simultaneously simplifying both t...
Source: Acta Biotheoretica - November 3, 2023 Category: Biomedical Science Authors: Evgeny V Mavrodiev Alexander Madorsky Source Type: research
On Pattern-Cladistic Analyses Based on Complete Plastid Genome Sequences
Acta Biotheor. 2023 Nov 3;71(4):22. doi: 10.1007/s10441-023-09475-5.ABSTRACTThe fundamental Hennigian principle, grouping solely on synapomorphy, is seldom used in modern phylogenetics. In the submitted paper, we apply this principle in reanalyzing five datasets comprising 197 complete plastid genomes (plastomes). We focused on the latter because plastome-based DNA sequence data gained dramatic popularity in molecular systematics during the last decade. We show that pattern-cladistic analyses based on complete plastid genome sequences can successfully resolve affinities between plant taxa, simultaneously simplifying both t...
Source: Acta Biotheoretica - November 3, 2023 Category: Biomedical Science Authors: Evgeny V Mavrodiev Alexander Madorsky Source Type: research
On Pattern-Cladistic Analyses Based on Complete Plastid Genome Sequences
Acta Biotheor. 2023 Nov 3;71(4):22. doi: 10.1007/s10441-023-09475-5.ABSTRACTThe fundamental Hennigian principle, grouping solely on synapomorphy, is seldom used in modern phylogenetics. In the submitted paper, we apply this principle in reanalyzing five datasets comprising 197 complete plastid genomes (plastomes). We focused on the latter because plastome-based DNA sequence data gained dramatic popularity in molecular systematics during the last decade. We show that pattern-cladistic analyses based on complete plastid genome sequences can successfully resolve affinities between plant taxa, simultaneously simplifying both t...
Source: Acta Biotheoretica - November 3, 2023 Category: Biomedical Science Authors: Evgeny V Mavrodiev Alexander Madorsky Source Type: research
On Pattern-Cladistic Analyses Based on Complete Plastid Genome Sequences
Acta Biotheor. 2023 Nov 3;71(4):22. doi: 10.1007/s10441-023-09475-5.ABSTRACTThe fundamental Hennigian principle, grouping solely on synapomorphy, is seldom used in modern phylogenetics. In the submitted paper, we apply this principle in reanalyzing five datasets comprising 197 complete plastid genomes (plastomes). We focused on the latter because plastome-based DNA sequence data gained dramatic popularity in molecular systematics during the last decade. We show that pattern-cladistic analyses based on complete plastid genome sequences can successfully resolve affinities between plant taxa, simultaneously simplifying both t...
Source: Acta Biotheoretica - November 3, 2023 Category: Biomedical Science Authors: Evgeny V Mavrodiev Alexander Madorsky Source Type: research
On Pattern-Cladistic Analyses Based on Complete Plastid Genome Sequences
Acta Biotheor. 2023 Nov 3;71(4):22. doi: 10.1007/s10441-023-09475-5.ABSTRACTThe fundamental Hennigian principle, grouping solely on synapomorphy, is seldom used in modern phylogenetics. In the submitted paper, we apply this principle in reanalyzing five datasets comprising 197 complete plastid genomes (plastomes). We focused on the latter because plastome-based DNA sequence data gained dramatic popularity in molecular systematics during the last decade. We show that pattern-cladistic analyses based on complete plastid genome sequences can successfully resolve affinities between plant taxa, simultaneously simplifying both t...
Source: Acta Biotheoretica - November 3, 2023 Category: Biomedical Science Authors: Evgeny V Mavrodiev Alexander Madorsky Source Type: research
Interior Operators and Their Relationship to Autocatalytic Networks
Acta Biotheor. 2023 Oct 27;71(4):21. doi: 10.1007/s10441-023-09472-8.ABSTRACTThe emergence of an autocatalytic network from an available set of elements is a fundamental step in early evolutionary processes, such as the origin of metabolism. Given the set of elements, the reactions between them (chemical or otherwise), and with various elements catalysing certain reactions, a Reflexively Autocatalytic F-generated (RAF) set is a subset R[Formula: see text] of reactions that is self-generating from a given food set, and with each reaction in R[Formula: see text] being catalysed from within R[Formula: see text]. RAF theory ha...
Source: Acta Biotheoretica - October 27, 2023 Category: Biomedical Science Authors: Mike Steel Source Type: research
Interior Operators and Their Relationship to Autocatalytic Networks
Acta Biotheor. 2023 Oct 27;71(4):21. doi: 10.1007/s10441-023-09472-8.ABSTRACTThe emergence of an autocatalytic network from an available set of elements is a fundamental step in early evolutionary processes, such as the origin of metabolism. Given the set of elements, the reactions between them (chemical or otherwise), and with various elements catalysing certain reactions, a Reflexively Autocatalytic F-generated (RAF) set is a subset R[Formula: see text] of reactions that is self-generating from a given food set, and with each reaction in R[Formula: see text] being catalysed from within R[Formula: see text]. RAF theory ha...
Source: Acta Biotheoretica - October 27, 2023 Category: Biomedical Science Authors: Mike Steel Source Type: research
Interior Operators and Their Relationship to Autocatalytic Networks
Acta Biotheor. 2023 Oct 27;71(4):21. doi: 10.1007/s10441-023-09472-8.ABSTRACTThe emergence of an autocatalytic network from an available set of elements is a fundamental step in early evolutionary processes, such as the origin of metabolism. Given the set of elements, the reactions between them (chemical or otherwise), and with various elements catalysing certain reactions, a Reflexively Autocatalytic F-generated (RAF) set is a subset R[Formula: see text] of reactions that is self-generating from a given food set, and with each reaction in R[Formula: see text] being catalysed from within R[Formula: see text]. RAF theory ha...
Source: Acta Biotheoretica - October 27, 2023 Category: Biomedical Science Authors: Mike Steel Source Type: research
Interior Operators and Their Relationship to Autocatalytic Networks
Acta Biotheor. 2023 Oct 27;71(4):21. doi: 10.1007/s10441-023-09472-8.ABSTRACTThe emergence of an autocatalytic network from an available set of elements is a fundamental step in early evolutionary processes, such as the origin of metabolism. Given the set of elements, the reactions between them (chemical or otherwise), and with various elements catalysing certain reactions, a Reflexively Autocatalytic F-generated (RAF) set is a subset R[Formula: see text] of reactions that is self-generating from a given food set, and with each reaction in R[Formula: see text] being catalysed from within R[Formula: see text]. RAF theory ha...
Source: Acta Biotheoretica - October 27, 2023 Category: Biomedical Science Authors: Mike Steel Source Type: research
