Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Targeted Hypermutation as a Survival Strategy: A Theoretical Approach
Acta Biotheor. 2023 Sep 5;71(4):20. doi: 10.1007/s10441-023-09471-9.ABSTRACTTargeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for analyzing hy...
Source: Acta Biotheoretica - September 5, 2023 Category: Biomedical Science Authors: Seymour Garte Source Type: research
Assessment of the Global Variance Effective Size of Subdivided Populations, and Its Relation to Other Effective Sizes
Acta Biotheor. 2023 Jul 17;71(3):19. doi: 10.1007/s10441-023-09470-w.ABSTRACTThe variance effective population size ([Formula: see text]) is frequently used to quantify the expected rate at which a population's allele frequencies change over time. The purpose of this paper is to find expressions for the global [Formula: see text] of a spatially structured population that are of interest for conservation of species. Since [Formula: see text] depends on allele frequency change, we start by dividing the cause of allele frequency change into genetic drift within subpopulations (I) and a second component mainly due to migration...
Source: Acta Biotheoretica - July 17, 2023 Category: Biomedical Science Authors: Ola H össjer Linda Laikre Nils Ryman Source Type: research
Assessment of the Global Variance Effective Size of Subdivided Populations, and Its Relation to Other Effective Sizes
Acta Biotheor. 2023 Jul 17;71(3):19. doi: 10.1007/s10441-023-09470-w.ABSTRACTThe variance effective population size ([Formula: see text]) is frequently used to quantify the expected rate at which a population's allele frequencies change over time. The purpose of this paper is to find expressions for the global [Formula: see text] of a spatially structured population that are of interest for conservation of species. Since [Formula: see text] depends on allele frequency change, we start by dividing the cause of allele frequency change into genetic drift within subpopulations (I) and a second component mainly due to migration...
Source: Acta Biotheoretica - July 17, 2023 Category: Biomedical Science Authors: Ola H össjer Linda Laikre Nils Ryman Source Type: research
Assessment of the Global Variance Effective Size of Subdivided Populations, and Its Relation to Other Effective Sizes
Acta Biotheor. 2023 Jul 17;71(3):19. doi: 10.1007/s10441-023-09470-w.ABSTRACTThe variance effective population size ([Formula: see text]) is frequently used to quantify the expected rate at which a population's allele frequencies change over time. The purpose of this paper is to find expressions for the global [Formula: see text] of a spatially structured population that are of interest for conservation of species. Since [Formula: see text] depends on allele frequency change, we start by dividing the cause of allele frequency change into genetic drift within subpopulations (I) and a second component mainly due to migration...
Source: Acta Biotheoretica - July 17, 2023 Category: Biomedical Science Authors: Ola H össjer Linda Laikre Nils Ryman Source Type: research
Assessment of the Global Variance Effective Size of Subdivided Populations, and Its Relation to Other Effective Sizes
Acta Biotheor. 2023 Jul 17;71(3):19. doi: 10.1007/s10441-023-09470-w.ABSTRACTThe variance effective population size ([Formula: see text]) is frequently used to quantify the expected rate at which a population's allele frequencies change over time. The purpose of this paper is to find expressions for the global [Formula: see text] of a spatially structured population that are of interest for conservation of species. Since [Formula: see text] depends on allele frequency change, we start by dividing the cause of allele frequency change into genetic drift within subpopulations (I) and a second component mainly due to migration...
Source: Acta Biotheoretica - July 17, 2023 Category: Biomedical Science Authors: Ola H össjer Linda Laikre Nils Ryman Source Type: research
Assessment of the Global Variance Effective Size of Subdivided Populations, and Its Relation to Other Effective Sizes
Acta Biotheor. 2023 Jul 17;71(3):19. doi: 10.1007/s10441-023-09470-w.ABSTRACTThe variance effective population size ([Formula: see text]) is frequently used to quantify the expected rate at which a population's allele frequencies change over time. The purpose of this paper is to find expressions for the global [Formula: see text] of a spatially structured population that are of interest for conservation of species. Since [Formula: see text] depends on allele frequency change, we start by dividing the cause of allele frequency change into genetic drift within subpopulations (I) and a second component mainly due to migration...
Source: Acta Biotheoretica - July 17, 2023 Category: Biomedical Science Authors: Ola H össjer Linda Laikre Nils Ryman Source Type: research
Assessment of the Global Variance Effective Size of Subdivided Populations, and Its Relation to Other Effective Sizes
Acta Biotheor. 2023 Jul 17;71(3):19. doi: 10.1007/s10441-023-09470-w.ABSTRACTThe variance effective population size ([Formula: see text]) is frequently used to quantify the expected rate at which a population's allele frequencies change over time. The purpose of this paper is to find expressions for the global [Formula: see text] of a spatially structured population that are of interest for conservation of species. Since [Formula: see text] depends on allele frequency change, we start by dividing the cause of allele frequency change into genetic drift within subpopulations (I) and a second component mainly due to migration...
Source: Acta Biotheoretica - July 17, 2023 Category: Biomedical Science Authors: Ola H össjer Linda Laikre Nils Ryman Source Type: research
