A Breakdown on Preprints With Eric Topol, MD A Breakdown on Preprints With Eric Topol, MD
WebMD ' s Chief Medical Officer, John Whyte, MD, MPH, speaks with Eric Topol, MD, executive vice president, Scripps Research and editor-in-chief, Medscape, about the role of preprints and how the pandemic has accelerated the dissemination of information.WebMD (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - February 16, 2022 Category: Intensive Care Tags: Infectious Diseases Expert Interview Source Type: news

Tenecteplase for Stroke Thrombolysis Up to 24 Hours? Tenecteplase for Stroke Thrombolysis Up to 24 Hours?
The thrombolytic tenecteplase may have a role in reestablishing blood flow in patients with large-vessel acute ischemic stroke up to 24 hours after stroke onset, a new trial from China suggests.Medscape Medical News (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - February 16, 2022 Category: Intensive Care Tags: Cardiology News Source Type: news

DOACs Comparable to Warfarin in CVT DOACs Comparable to Warfarin in CVT
DOACs were just as effective as warfarin in preventing future thrombotic events in patients with cerebral venous thrombosis stroke, with less major bleeding, in the retrospective ACTION-CVT study.Medscape Medical News (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - February 15, 2022 Category: Intensive Care Tags: Cardiology News Source Type: news

ECG Challenge: What's Behind This Man's Mid-systolic Murmur? ECG Challenge: What's Behind This Man's Mid-systolic Murmur?
A 55-year-old with aortic stenosis presents with a mid-systolic murmur but feels fine. What ' s going on?Medscape Cardiology (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - February 14, 2022 Category: Intensive Care Tags: Cardiology Clinical Case Source Type: news

The impact of sedative choice on intracranial and systemic physiology in moderate to severe traumatic brain injury: a scoping review - Jeffcote T, Weir T, Anstey J, McNamara R, Bellomo R, Udy A.
Although sedative use is near-ubiquitous in the acute management of moderate to severe traumatic brain injury (m-sTBI), the evidence base for these agents is undefined. This review summarizes the evidence for analgosedative agent use in the intensive care ... (Source: SafetyLit)
Source: SafetyLit - February 14, 2022 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Boost Now for COVID or Wait? Boost Now for COVID or Wait?
Drs Robert Glatter, Paul Offit, and Paul Sax discuss the current data about boosters for COVID-19.Medscape Emergency Medicine (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - February 11, 2022 Category: Intensive Care Tags: Emergency Medicine Commentary Source Type: news

Vitamin C for   5 days is associated with decreased hospital mortality in sepsis subgroups: a nationwide cohort study
Background: Previous randomized trials of vitamin C, hydrocortisone, and thiamine on sepsis were limited by short-term vitamin C administration, heterogeneous populations, and the failure to evaluate each component ' s effect. The purpose of this study was to determine whether vitamin C alone for ≥ 5 days or in combination with corticosteroids and/or thiamine was associated with decreased mortality across the sepsis population and subpopulation.; Methods: Nationwide population-based study conducted using the Korean National Health Insurance Service database. A total of 384,282 adult patien ts with sepsis who were admitte...
Source: Current Awareness Service for Health (CASH) - February 10, 2022 Category: Consumer Health News Source Type: news

Implementation and evaluation of sepsis surveillance and decision support in medical ICU and emergency department
Conclusions: A sepsis surveillance system incorporating decision support or completion feedback was not associated with improved sepsis care and patient outcomes. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 10, 2022 Category: Consumer Health News Source Type: news

Sepsis and Total Joint Arthroplasty
The number of annual total joint arthroplasties (TJA) is increasing. Periprosthetic joint infections (PJI) occur when there is infection involving the prosthesis and surrounding tissue, which has the potential to develop into sepsis if left untreated. Sepsis in patients who have undergone TJA is life threatening and requires urgent treatment. If sepsis is due to PJI, the focus should be on early intravenous antibiotics with aspiration as soon as possible to diagnose the infection. Patients who develop sepsis after surgery for PJI are particularly at high risk for mortality and need to be treated in the intensive care unit....
Source: Current Awareness Service for Health (CASH) - February 10, 2022 Category: Consumer Health News Source Type: news

Analysis of Missed Sepsis Patients in a Pediatric Emergency Department With a Vital Sign-Based Electronic Sepsis Alert
Conclusions: In an ED with an electronic sepsis alert, missed patients often had positive sepsis alerts but were not treated for sepsis. Missed patients were more likely than sepsis pathway patients to require escalation of care after admission and less likely to receive timely antibiotics. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 10, 2022 Category: Consumer Health News Source Type: news

Effect of Nurse-Led Goal-Directed Lung Physical Therapy on the Prognosis of Pneumonia in Sepsis Patients in the ICU: A Prospective Cohort Study
This study aimed to investigate the effects of nurse-led GDLPT on the prognosis of pneumonia in sepsis patients in the ICU.; Methods: We performed a prospective 2-phase (before-and-after) study over 3 years. After an observational phase (phase 1, n = 188), we designed, implemented, and evaluated a nurse-led GDLPT protocol (phase 2, n = 359) for pneumonia in sepsis patients in the ICU. The primary outcome was 28-day mortality.; Results: We evaluated 742 critically ill patients with sepsis from January 2017 to January 2020. Among the 742 sepsis patients, 609 were diagnosed with pneumonia and 547 who met the inclusion criteri...
Source: Current Awareness Service for Health (CASH) - February 10, 2022 Category: Consumer Health News Source Type: news

Prediction of prognosis in sepsis patients by the SOFA score combined with miR-150
Background: The sequential organ failure assessment (SOFA) score, designed to evaluate sepsis-associated organ dysfunction in intensive care unit (ICU) patients, is associated with the prognosis of sepsis patients. MicroRNA-150 (miR-150) is one of the first miRs to be detected in patients with sepsis and other critical illnesses, and to have an association with the prognosis of critical illness and sepsis.; Objectives: To assess the predictive value of the combination of the SOFA score and miR-150 levels for the prognosis of sepsis patients.; Material and Methods: We retrospectively included 437 adult patients with sepsis ...
Source: Current Awareness Service for Health (CASH) - February 10, 2022 Category: Consumer Health News Source Type: news

Conditions Linked to Severe COVID-19 in Cancer Survivors Conditions Linked to Severe COVID-19 in Cancer Survivors
Many cancer survivors may have one or more underlying conditions, putting them at increased risk for severe COVID-19-associated illness.Journal of the National Cancer Institute (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - February 9, 2022 Category: Intensive Care Tags: Hematology-Oncology Journal Article Source Type: news

Isc 2022 isc 2022
Read clinically focused news coverage of key developments from ISC 2022Medscape Neurology (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - February 9, 2022 Category: Intensive Care Tags: Critical Care Conference Coverage Source Type: news

Predicting mortality following traumatic brain injury or subarachnoid hemorrhage: an analysis of the validity of standardized mortality ratios obtained from the APACHE II and ICNARCH-2018 models - Rowe M, Brown J, Marsh A, Thompson J.
INTRODUCTION: Standardized mortality ratios (SMRs), calculated using the Acute Physiology, Age, Chronic Health Evaluation II (APACHE II) and Intensive Care National Audit and Research Centre H-2018 (ICNARCH-2018) risk prediction models, are widely used in ... (Source: SafetyLit)
Source: SafetyLit - February 9, 2022 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news