Reversal cells may tip the balance between bone formation and resorption in health and disease (AlphaGalileo, 6 June 2013)
A study from Denmark published in The American Journal of Pathology attempts to characterise "reversal cells", which are proposed to be involved in bone remodelling, in the context of postmenopausal osteoporosis and primary hyperparathyroidism.
Full article (Source: Society for Endocrinology)
Source: Society for Endocrinology - June 7, 2013 Category: Endocrinology Source Type: news
Reversal Cells May Tip The Balance Between Bone Formation And Resorption In Health And Disease
This study is published in the May 2013 issue of The American Journal of Pathology... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 7, 2013 Category: Consumer Health News Tags: Bones / Orthopedics Source Type: news
Reversal cells may tip the balance between bone formation and resorption in health and disease
This study is published in the July 2013 issue of The American Journal of Pathology. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 6, 2013 Category: Global & Universal Source Type: news
Secondary Hyperparathyroidism Impacts Antiresorptive TherapySecondary Hyperparathyroidism Impacts Antiresorptive Therapy
Can higher PTH levels negatively influence the therapeutic efficacy of bisphosphonates for osteoporosis? BMC Musculoskeletal Disorders (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 13, 2013 Category: Consumer Health News Tags: Orthopaedics Journal Article Source Type: news
PTH Best Risk Predictor in Parathyroid Disease (CME/CE)
(MedPage Today) -- Higher parathyroid hormone levels may help predict the long-term risk of death and cardiovascular disease in patients with untreated primary hyperparathyroidism, Scottish researchers found. (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - April 24, 2013 Category: Endocrinology Source Type: news
Primary-Care Docs Overlooking Primary HyperparathyroidismPrimary-Care Docs Overlooking Primary Hyperparathyroidism
Parathyroid hormone levels are not being checked in over half of patients with hypercalcemia, leading to under detection of primary hyperparathyroidism, new data suggest. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 17, 2013 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news
What Causes Hypercalcemia?
Discussion
Calcium homeostasis is regulated by mechanisms involving the absorption from the gastrointestinal tract, bone deposition and resorption, and renal excretion. To review Vitamin D homeostasis click here.
Serum calcium is found in three forms: free (47%), protein bound (43%) and diffusable calcium complexes (10%). The protein binding proteins are albumin (80%) and globulin (20%). The free calcium is the most important biologically. Acidosis also increases free calcium and alkalosis decreases free calcium.
Problems associated with hypercalcemia include nausea, emesis, abdominal pain, constipation, polyuria, dehydra...
Source: PediatricEducation.org - March 25, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news
Older African American Women At Increased Risk For Endocrine Disorder, The Most Common Cause Of Elevated Calcium Levels
Unusually high calcium levels in the blood can almost always be traced to primary hyperparathyroidism, an undertreated, underreported condition that affects mainly women and the elderly, according to a new study by UCLA researchers. The condition, which results from overactive parathyroid glands and includes symptoms of bone loss, depression and fatigue that may go undetected for years, is most often seen in African American women over the age of 50, the researchers discovered... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 25, 2013 Category: Consumer Health News Tags: Endocrinology Source Type: news
UCLA study finds endocrine disorder is most common cause of elevated calcium levels
Unusually high calcium levels in the blood can almost always be traced to primary hyperparathyroidism, an undertreated, underreported condition that affects mainly women and the elderly, according to a new study by UCLA researchers.
The condition, which results from overactive parathyroid glands and includes symptoms of bone loss, depression and fatigue that may go undetected for years, is most often seen in African American women over the age of 50, the researchers discovered.
The study, currently online in the Journal of Clinical Endocrinology and Metabolism, is one of the first to examine a large, ra...
Source: UCLA Newsroom: Health Sciences - February 21, 2013 Category: Universities & Medical Training Source Type: news
UCLA study finds endocrine disorder is most common cause of elevated calcium levels
(University of California - Los Angeles Health Sciences) UCLA researchers found that unusually high calcium levels in the blood can almost always be traced to primary hyperparathyroidism, an undertreated, underreported condition that affects mainly women and the elderly. The condition, which results from overactive parathyroid glands and includes symptoms of bone loss, depression and fatigue that may go undetected for years, is most often seen in African American women over the age of 50, the researchers discovered. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 21, 2013 Category: Global & Universal Source Type: news
pHPT and MEN1 alterations
Primary hyperparathyroidism (pHPT) represents one of the most common endocrine disorders in western populations. The genetic alterations underlying the sporadic forms of pHPT remain poorly understood. Alvelos et al. performed molecular characterisation of a series of sporadic pHPT cases. The results of their study suggest that MEN1 alterations, may represent the most prevalent genetic alteration in sporadic parathyroid tumours. Alvelos et al. (2013) European Journal of Endocrinology 168, 119-128.
Read the full article at DOI: 10.1530/EJE-12-0327. (Source: Society for Endocrinology)
Source: Society for Endocrinology - February 11, 2013 Category: Endocrinology Source Type: news
Information Links Lithium to Thyroid, Parathyroid Problems
A review in <i>The Lancet</i> found that in addition to the known potential for causing weight gain, taking lithium may increase the activity of the thyroid and parathyroid glands. Because of the increased risk for hyperparathyroidism, it is now recommended that doctors check blood calcium levels, an indicator for parathyroid activity, before beginning lithium therapy and periodically while the patient is taking lithium.<br /><br />
Lithium is a first-line treatment for bipolar disorder and may be used as add-on treatment for major depression.<p>
The review found that patients taking lithium...
Source: About.com Bipolar Disorder - January 14, 2013 Category: Psychiatry Source Type: news
Eplerenone on PTH Levels in Primary HyperparathyroidismEplerenone on PTH Levels in Primary Hyperparathyroidism
Can this mineralocorticoid receptor antagonist reduce PTH secretion? BMC Endocrine Disorders (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 14, 2013 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news
Endocrinology: Images in Clinical Medicine
Editor: V. Dimov, M.D., Assistant Professor at University of ChicagoA painful swollen thigh in a diabetic patient: diabetic myonecrosis. The Lancet, 05/2014.Subperiosteal Bone Resorption due to primary hyperparathyroidism caused by parathyroid adenoma. NEJM, 05/2014.Eschar Formation from Testosterone Patch.Homozygous familial hypercholesterolaemia. Lancet, 04/2012.Insulin-Induced Lipohypertrophy. NEJM, 02/2012.Ectopic Cushing ' s Syndrome. NEJM, 12/2011.Porphyria Cutanea Tarda. NEJM, 09/2011.Auricular Cartilage Calcification and Adrenal Insufficiency. NEJM, 01/2011.Hemichorea –Hemiballism after Diabetic Ketoaci...
Source: Clinical Cases and Images - August 22, 2009 Category: General Medicine Tags: Endocrinology Images Source Type: news
