Triptolide nanogel treats liver cancer
Coated version of naturally occurring antitumor compound appears to be more effective against hepatocellular carcinoma than conventional therapies (Source: Nanotechweb.org News)
Source: Nanotechweb.org News - August 16, 2014 Category: Nanotechnology Authors: Belle Dumé Source Type: news

Entecavir Does Not Eliminate HCC Risk in Hepatitis B PatientsEntecavir Does Not Eliminate HCC Risk in Hepatitis B Patients
Patients taking entecavir for chronic hepatitis B are still at risk for hepatocellular carcinoma (HCC), a recent study suggests. Reuters Health Information (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - July 23, 2014 Category: Gastroenterology Tags: Hematology-Oncology News Source Type: news

Food imagery ideal for teaching doctors -- but they must have strong stomachs
From 'beer belly' to 'port wine stain,' food imagery has a long history of being used in medicine to identify the diagnostic features of a wide range of conditions and ailments, says a pathologist. In a gastronomic tour of some of the many food descriptors used in medicine, the author highlights imagery such as 'anchovy sauce' to describe the pus from a liver abscess, through 'sago spleen' to indicate protein (amyloid) deposits, to 'oat cell carcinoma,' which describes the appearance of a highly aggressive form of lung cancer. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - July 10, 2014 Category: Science Source Type: news

Analysis finds evidence lacking for HCC screening
Screening for hepatocellular carcinoma (HCC) in patients with chronic liver (more) (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - June 18, 2014 Category: Radiology Source Type: news

State of the Art: Treatment of Nonalcoholic SteatohepatitisState of the Art: Treatment of Nonalcoholic Steatohepatitis
Patients with NASH are at an increased risk for developing cirrhosis and hepatocellular carcinoma. How can clinicians best treat these patients to prevent these more serious diseases from occurring? Current Opinion in Gastroenterology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 17, 2014 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Analysis Finds Scant Evidence to Support Liver Cancer Screening in High-Risk Patients (FREE)
By Amy Orciari Herman Edited by David G. Fairchild, MD, MPH, and André Sofair, MD, MPH There's little evidence that screening high-risk adults for hepatocellular carcinoma (HCC) improves survival, according to an Annals of Internal Medicine article.Researchers … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - June 17, 2014 Category: Primary Care Source Type: news

HBV Therapy May Cut Liver Cancer Risk (CME/CE)
(MedPage Today) -- Antiviral treatment for hepatitis B virus is associated with a lower risk of hepatocellular carcinoma, researchers reported. (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - June 11, 2014 Category: Gastroenterology Source Type: news

Antiviral therapy may prevent liver cancer in hepatitis B patients
(Henry Ford Health System) Researchers have found that antiviral therapy may be successful in preventing hepatitis B virus from developing into the most common form of liver cancer, hepatocellular carcinoma. 'The results of this study allow us to reassure our patients that we are not just treating their viral levels, but that antiviral therapy may actually lessen their chance of developing liver cancer,' said the study's lead investigator, Henry Ford Health System's Stuart C. Gordon, M.D. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 9, 2014 Category: Global & Universal Source Type: news

Tekmira Initiating Phase I/II Clinical Trial in Patients with Hepatocellular Carcinoma
(Source: Medical News (via PRIMEZONE))
Source: Medical News (via PRIMEZONE) - May 27, 2014 Category: Pharmaceuticals Source Type: news

Risk Factors for Hepatocellular Carcinoma in HCV PatientsRisk Factors for Hepatocellular Carcinoma in HCV Patients
Under what circumstances are patients with HCV at most risk for developing hepatocellular carcinoma? This new study investigates. Journal of Viral Hepatitis (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 26, 2014 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Hepatocellular Carcinoma: Clinical Frontiers and PerspectivesHepatocellular Carcinoma: Clinical Frontiers and Perspectives
Hepatocellular carcinoma often develops in patients with cirrhosis. What treatment options, both surgical and medical, are available to treat this liver disease? Gut (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - May 7, 2014 Category: Gastroenterology Tags: Gastroenterology Journal Article Source Type: news

HCC screening boosts survival rate in cirrhosis patients
Screening cirrhosis patients with liver ultrasound for hepatocellular carcinoma (more) (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - April 1, 2014 Category: Radiology Source Type: news

Screening for liver cancer in patients with cirrhosis
(PLOS) In a systematic review and meta-analysis of 47 studies with 15,158 patients, Amit Singal, University of Texas Southwestern Medical Center, and colleagues found that patients with cirrhosis who underwent surveillance, via liver ultrasound with or without measurement of serum alpha fetoprotein, for hepatocellular carcinoma had cancers detected at an earlier stage, were more likely to receive curative instead of palliative treatment, and had longer survival. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 1, 2014 Category: Cancer & Oncology Source Type: news

Court bans export of generic kidney, liver cancer medication
Sorafenat is the generic alternative to Bayer's Nexavar, and is used to treat a type of kidney cancer called advanced renal cell carcinoma as well as liver cancer.03/28/2014 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - March 28, 2014 Category: Cancer & Oncology Source Type: news

Treatment of Patients With Dual Hepatitis C and BTreatment of Patients With Dual Hepatitis C and B
Are patients with hepatitis C and B treated with pegylated interferon and an antiviral at an increased risk for developing hepatocellular carcinoma? This new study explores the connection. Gut (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 26, 2014 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

101 liver cancer drug candidates pave the way to personalized medicine
The heart disease drug perhexiline is one of 101 compounds predicted to prevent cancer growth in most patients suffering from our most common liver cancer, HCC. This is an outcome from a novel simulation-based approach using personal sets of proteins of six HCC patients."This is the first time personalized models have been used to find and evaluate new potential drugs," says Professor Jens Nielsen at Chalmers University of Technology.Our most common liver cancer, Hepatocellular carcinoma, HCC, causes more than half a million deaths worldwide every year. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 20, 2014 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Occult HBV Infection and Hepatocellular CarcinomaOccult HBV Infection and Hepatocellular Carcinoma
This article sheds light on the connection between hepatitis B and the development of hepatocellular carcinoma. What does the new research tell us? Journal of Viral Hepatitis (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 17, 2014 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Axitinib – Treatment for Advanced Renal Cell Carcinoma
Inlyta (axitinib) was developed by Pfizer for treating advanced renal cell carcinoma (ARCC) and hepatocellular carcinoma. (Source: Drug Development Technology)
Source: Drug Development Technology - March 5, 2014 Category: Pharmaceuticals Source Type: news

Unusual genetic mutation discovered with a link to adolescent liver cancer
In the race for better treatments and possible cures, rare diseases are often left behind. In a collaboration of researchers at The Rockefeller University, Memorial Sloan Kettering Cancer Center and the New York Genome Center (NYGC), an unusual mutation has been found that is strongly linked to one such disease: a rare liver cancer that affects teens and young adults. The results, published this week in Science, suggest that the mutation plays a key role in the development of the disease, called fibrolamellar hepatocellular carcinoma, and may also underlie more common cancers as well. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 4, 2014 Category: Consumer Health News Tags: Liver Disease / Hepatitis Source Type: news

Unusual genetic mutation found linked to adolescent liver cancer
In the race for better treatments and possible cures, rare diseases are often left behind. Through a collaboration of researchers, an unusual mutation has been found that is strongly linked to one such disease: a rare liver cancer that affects teens and young adults. The research suggests that the mutation plays a key role in the development of the disease, called fibrolamellar hepatocellular carcinoma, and may also underlie more common cancers as well. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 28, 2014 Category: Science Source Type: news

Science 343: 1010-1014 (14-2-28)
Science 343: 1010-1014 Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma Joshua N. Honeyman, Elana P. Simon, Nicolas Robine, Rachel Chiaroni-Clarke, David G. Darcy, Irene Isabel P. Lim, Caroline E. Gleason, Jennifer M. Murphy, Brad R. Rosenberg, … More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - February 28, 2014 Category: Biomedical Science Authors: pubaff Tags: Research Update Source Type: news

Hepatitis C Infection and Higher Risk of Death From Non-liver CancersHepatitis C Infection and Higher Risk of Death From Non-liver Cancers
In addition to their increased risk of death from hepatocellular carcinoma, chronic hepatitis C virus (HCV)-infected patients also have a higher mortality rate from non-Hodgkin lymphoma and pancreatic, rectal, and oral and pharyngeal cancers. Reuters Health Information (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - February 26, 2014 Category: Gastroenterology Tags: Hematology-Oncology News Source Type: news

Celsion Announces FDA Clearance of the OPTIMA Study - A Pivotal Phase III Trial of ThermoDox in Primary Liver Cancer
Study Developed in Consultation with Clinical Advisors, Statistical Experts and FDA Compelling Survival Data Supports Development Trial Advances Global Regulatory Strategy in Key Markets LAWRENCEVILLE, N.J., Feb. 24, 2014 -- (Healthcare Sales & Ma... Biopharmaceuticals, Drug Delivery, Oncology, FDACelsion, ThermoDox, liposome, hepatocellular carcinoma, liver cancer (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - February 24, 2014 Category: Pharmaceuticals Source Type: news

Trials in Esophageal Ca, HCC Fall Short
SAN FRANCISCO (MedPage Today) -- Patients with esophageal cancer derived no survival benefit with the addition of cetuximab to chemoradiation, while everolimus fared no better in a trial of patients with hepatocellular carcinoma (HCC) that had progressed during or after treatment with sorafenib. (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - January 19, 2014 Category: Gastroenterology Source Type: news

Surgery Tied To Better OS in Huge Liver Tumors
(MedPage Today) -- Surgical resection of huge hepatocellular carcinomas was linked with better survival outcomes versus transarterial chemoembolization (TACE), researchers found. (Source: MedPage Today Surgery)
Source: MedPage Today Surgery - January 5, 2014 Category: Surgery Source Type: news

Outcome of Sorafenib Treatment in Patients With Advanced HCCOutcome of Sorafenib Treatment in Patients With Advanced HCC
Is the tyrosine kinase inhibitor, sorafenib, an effective treatment in patients with advanced hepatocellular carcinoma refractory to chemotherapy? Journal of Gastroenterology and Hepatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 30, 2013 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Treating Hepatocellular Carcinoma After First-line SorafenibTreating Hepatocellular Carcinoma After First-line Sorafenib
How can clinicians successfully treat advanced hepatocellular carcinoma after first-line treatment with sorafenib? This new study outlines the other therapeutic options. Therapeutic Advances in Gastroenterology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 27, 2013 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Gene deficiency in males 'could cause diabetes and liver cancer'
Scientists have discovered a genetic deficiency in males that could prompt the development of the most common type of liver cancer - hepatocellular carcinoma - and type 2 diabetes. This is according to a study published in the journal Cancer Cell.Researchers from Michigan State University, led by Hua Xiao of the College of Human Medicine at the university, say their findings could lead to new therapeutic interventions for both conditions.Type 2 diabetes is commonly known to be a risk factor for liver cancer. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 11, 2013 Category: Consumer Health News Tags: Genetics Source Type: news

Risk factor for liver cancer increased by diabetes across ethnic groups
Diabetes was associated with an increased risk for developing a type of liver cancer called hepatocellular carcinoma, and this association was highest for Latinos, followed by Hawaiians, African-Americans, and Japanese-Americans, according to results presented at the Sixth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved."People with diabetes have a two- to threefold higher risk for hepatocellular carcinoma compared with those without diabetes," said V. Wendy Setiawan, Ph.D. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 11, 2013 Category: Consumer Health News Tags: Diabetes Source Type: news

Diabetes identified as risk factor for liver cancer across ethnic groups
(American Association for Cancer Research) Diabetes was associated with an increased risk for developing a type of liver cancer called hepatocellular carcinoma, and this association was highest for Latinos, followed by Hawaiians, African-Americans, and Japanese-Americans, according to results presented here at the Sixth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held Dec. 6-9. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - December 8, 2013 Category: Global & Universal Source Type: news

Autoimmune hepatitis - 2013 Lancet review
In common with many autoimmune diseases, autoimmune hepatitis is associated with non-organ-specific antibodies in the context of hepatic autoimmunity.Autoimmune hepatitis can present in acute or chronic forms. Remission is achievable in up to 85% of cases. For the remaining patients, immunosuppression is an option. Liver transplantation provides an excellent outcome for patients with acute liver failure or complications of end-stage liver disease, including hepatocellular carcinoma. References:Autoimmune hepatitis: The Lancet http://bit.ly/1aApnxp Posted at Clinical Cases and Images. Stay updated and subscribe, follow u...
Source: Clinical Cases and Images - November 22, 2013 Category: Journals (General) Tags: Gastroenterology Hepatitis Lancet Review Source Type: news

Surge of Liver Cancer Patients on Transplant WaitlistsSurge of Liver Cancer Patients on Transplant Waitlists
On liver transplant waitlists, the recent increase of patients with hepatitis C is related to hepatocellular carcinoma, raising questions about fair allocation of donor livers. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 12, 2013 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

Outcome of Sorafenib Therapy in Hepatocellular CarcinomaOutcome of Sorafenib Therapy in Hepatocellular Carcinoma
In patients with advanced hepatocellular carcinoma, for whom surgical management is not an option, how effective is sorafenib in the treatment of the disease? Journal of Gastroenterology and Hepatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 11, 2013 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Systemic Therapies in Hepatocellular CarcinomaSystemic Therapies in Hepatocellular Carcinoma
Conventional systemic therapy has proved ineffective in HCC. Today it's possible to use our knowledge of molecular hepatocarcinogenesis to provide a targeted therapy. Future Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 11, 2013 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Discovered a mechanism that induces migration of tumor cells in liver cancer
(IDIBELL-Bellvitge Biomedical Research Institute) Researchers from the Biological clues of the invasive and metastatic phenotype group of the Bellvitge Biomedical Research Institute led by Isabel Fabregat have discovered the relationship between the TGFb signalling pathways and CXCR4 in hepatocellular carcinoma . The cytokine TGFb is dependent of CXCR4 to induce tumor cell migratory ability. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 6, 2013 Category: Global & Universal Source Type: news

Three cups of coffee a day could halve the risk of liver cancer
An Italian study found the drink reduces the risk of the most common type of liver cancer, hepatocellular carcinoma (HCC). (Source: the Mail online | Health)
Source: the Mail online | Health - October 24, 2013 Category: Consumer Health News Source Type: news

Coffee consumption reduces risk of liver cancer
(American Gastroenterological Association) Coffee consumption reduces risk of hepatocellular carcinoma, the most common type of liver cancer, by about 40 percent, according to an up-to-date meta-analysis published in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association. Further, some data indicate that three cups of coffee per day reduce liver cancer risk by more than 50 percent. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 22, 2013 Category: Global & Universal Source Type: news

Diagnosis and Treatment of Hereditary HemochromatosisDiagnosis and Treatment of Hereditary Hemochromatosis
Iron overload is being recognized to play a carcinogenic role in hepatocellular carcinoma and other cancers. Find out more about the connection. Expert Review of Gastroenterology and Hepatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 21, 2013 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Liver cancer progenitor cells identified before tumors become visible
For the first time, researchers at the University of California, San Diego School of Medicine have isolated and characterized the progenitor cells that eventually give rise to malignant hepatocellular carcinoma (HCC) tumors - the most common form of liver cancer. The researchers found ways to identify and isolate the HCC progenitor cells (HcPC) long before actual tumors were apparent... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 14, 2013 Category: Consumer Health News Tags: Liver Disease / Hepatitis Source Type: news

Researchers identify liver cancer progenitor cells before tumors become visible
(University of California - San Diego) For the first time, researchers at the University of California, San Diego School of Medicine have isolated and characterized the progenitor cells that eventually give rise to malignant hepatocellular carcinoma (HCC) tumors -- the most common form of liver cancer. The researchers found ways to identify and isolate the HCC progenitor cells long before actual tumors were apparent. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 10, 2013 Category: Cancer & Oncology Source Type: news

Computer Simulation of the Metastatic Progression
A novel computer model based on a discrete event simulation procedure describes quantitatively the processes underlying the metastatic cascade. Analytical functions describe the size of the primary tumor and the metastases, while a rate function models the intravasation events of the primary tumor and metastases. Events describe the behavior of the malignant cells until the formation of new metastases. The results of the computer simulations are in quantitative agreement with clinical data determined from a patient with hepatocellular carcinoma in the liver. The model provides a more detailed view on the process than a con...
Source: Springer protocols feed by Cancer Research - October 8, 2013 Category: Cancer & Oncology Source Type: news

Metastatic site impacts survival in targeted RCC treatment
Bone and liver metastases may have the heaviest impact on the survival of patients receiving targeted therapy for metastatic renal cell carcinoma, suggest data from the International Metastatic Renal Cell Carcinoma Database Consortium. (Source: MedWire News - Urology)
Source: MedWire News - Urology - October 7, 2013 Category: Urology & Nephrology Source Type: news

Risk Factors for Hepatocellular Carcinoma in the USRisk Factors for Hepatocellular Carcinoma in the US
Who is most at risk for developing hepatocellular carcinoma in the US? This new study breaks down the data. The American Journal of Gastroenterology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 3, 2013 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Metastatic site impacts survival in targeted RCC treatment
Bone and liver metastases may have the heaviest impact on the survival of patients receiving targeted therapy for metastatic renal cell carcinoma, suggest data from the International Metastatic Renal Cell Carcinoma Database Consortium. (Source: MedWire News - Oncology)
Source: MedWire News - Oncology - September 24, 2013 Category: Cancer & Oncology Source Type: news

Hepatocellular CarcinomaHepatocellular Carcinoma
Liver resection and transplantation remain 2 of the preferred treatments for hepatocellular carcinoma. Is one method more successful than the other? Seminars in Liver Disease (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 19, 2013 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Hepatitis B immunization program in Taiwan associated with reduction in chronic liver disease deaths
"Hepatitis B virus (HBV) infection causes infant fulminant hepatitis (IFH), and chronic HBV infection may progress to chronic liver disease (CLD) and hepatocellular carcinoma (HCC). Taiwan launched a nationwide HBV immunization program for newborns in July 1984, which has successfully lowered the prevalence of chronic HBV carriers, incidence of HCC, and mortality of IFH in vaccinated birth cohorts. The mortality of CLD before and after HBV immunization has never been examined," write Chun-Ju Chiang, Ph.D., of National Taiwan University, Taipei, and colleagues... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 3, 2013 Category: Consumer Health News Tags: Liver Disease / Hepatitis Source Type: news

The Effect of Coffee Consumption on the Development of HCCThe Effect of Coffee Consumption on the Development of HCC
What is the connection between coffee consumption and the potential risk for hepatocellular carcinoma? Does it offer a protective effect? Liver International (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 12, 2013 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Novartis’ Afinitor Phase III trial fails to meet primary end-point
Switzerland-based Novartis’ Phase III trial of advanced liver cancer drug, Afinitor (everolimus), did not meet the primary end-point of overall survival benefit in patients with advanced hepatocellular carcinoma (HCC) after progression on or intolera… (Source: Drug Development Technology)
Source: Drug Development Technology - August 8, 2013 Category: Pharmaceuticals Source Type: news

Pitfalls in Diagnosing Scirrhous Hepatocellular CarcinomaPitfalls in Diagnosing Scirrhous Hepatocellular Carcinoma
Scirrhous hepatocellular carcinoma, a rare subtype of hepatocellular carcinoma, can be difficult to distinguish from other variants. What reliable immunohistochemical markers can be utilized? Modern Pathology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 8, 2013 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news

New Evidence For The Genetic Bases Of Liver Cancer
The Asian Cancer Research Group (ACRG), an independent, not-for-profit company in collaboration with BGI, the world's largest genomics organization, and The University of Hong Kong (HKU), jointly announced the publication of findings from a study of recurrent mutations in hepatocellular carcinoma (HCC), one of the most deadly cancers worldwide, in the international journal Genome Research . The study provides new insights into potential therapeutic intervention strategies for this common form of liver cancer... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 3, 2013 Category: Consumer Health News Tags: Liver Disease / Hepatitis Source Type: news