ITGA6 Targeting NIR-II Fluorescence Image Guided Surgery
Conditions: Hepatocellular Carcinoma Interventions: Drug: RD-Cy7 fluorophore Sponsors: Institute of Automation, Chinese Academy of Sciences Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 12, 2024 Category: Research Source Type: clinical trials

FOLFOX-HAIC Plus Lenvatinib and Toripalimab vs. FOLFOX-HAIC Plus Lenvatinib for Advanced Hepatocellular Carcinoma: a Randomized Controlled and Double-blind Trial
Conditions: Hepatocellular Carcinoma Interventions: Procedure: Hepatic arterial infusion chemotherapy; Drug: Lenvatinib; Drug: Toripalimab; Drug: oxaliplatin , fluorouracil, and leucovorin Sponsors: Sun Yat-sen University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 11, 2024 Category: Research Source Type: clinical trials

Atezolizumab Plus Bevacizumab Versus Sintilimab Plus Bevacizumab With Transarterial Chemoembolization and Hepatic Arterial Infusion Chemotherapy in Unresectable Hepatocellular Carcinoma: A Multicenter Real-World Study
Conditions: Hepatocellular Carcinoma Interventions: Drug: Atezolizumab combined with Bevacizumab; Drug: Sintilimab combined with Bevacizumab; Procedure: Transcatheter arterial chemoembolization and hepatic arterial infusion chemotherapy Sponsors: Sun Yat-sen University Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 10, 2024 Category: Research Source Type: clinical trials

Immunotherapy For Adults With GPC3-Positive Solid Tumors Using IL-15 and IL-21 Armored GPC3-CAR T Cells
Conditions: Hepatoblastoma; Hepatocellular Carcinoma; Wilms Tumor; Malignant Rhabdoid Tumor; Yolk Sac Tumor; Rhabdomyosarcoma; Liposarcoma; Embryonal Sarcoma of Liver Interventions: Genetic: 21.15.GPC3-CAR T cells Sponsors: Baylor College of Medicine; Center for Cell and Gene Therapy, Baylor College of Medicine Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 10, 2024 Category: Research Source Type: clinical trials

A Study of Cadonilimab Combined With AK112 as Second-line Therapy in Patients With Advanced Hepatocellular Carcinoma
Conditions: Hepatocellular Carcinoma Interventions: Biological: AK104+AK112 Sponsors: Harbin Medical University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 9, 2024 Category: Research Source Type: clinical trials

LTFU for All Cell and Gene Therapy Studies
Conditions: Hepatocellular Carcinoma; Prostate Cancer Interventions: Biological: AZD5851 Sponsors: AstraZeneca Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 8, 2024 Category: Research Source Type: clinical trials

Dendritic Cell Vaccination to Prevent Hepatocellular Carcinoma Recurrence After Liver Resection-phase II Clinical Trial
Conditions: Hepatocellular Carcinoma Interventions: Biological: Autologous Dendritic Cell Sponsors: Chang Gung Memorial Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 5, 2024 Category: Research Source Type: clinical trials

Entecavir versus tenofovir for prevention of hepatitis B virus-associated hepatocellular carcinoma after curative resection: study protocol for a randomized, open-label trial
This study is a randomized, open-label trial. A total of 240 participants will be randomized 1:1 into groups receiving TDF or entecavir monotherapy. The two groups will be compared in terms of recurrence-free and overall survival at 1, 3, and 5  years after surgery; adverse events; virological response; rate of alanine transaminase normalization; and seroreactivity at 24 and 48 weeks after surgery.DiscussionThis study will compare long-term survival between patients with HBV-associated HCC who receive TDF or entecavir monotherapy. Numerous outcomes related to prognosis will be analyzed and compared in this study.Trial re...
Source: Trials - January 5, 2024 Category: Research Source Type: clinical trials

DEB-TACE With Visualable Microspheres Versus PVA Microspheres for HCC
Conditions: Hepatocellular Carcinoma Interventions: Device: DEB-TACE with visualable microspheres; Device: DEB-TACE with PVA microspheres Sponsors: Zhongda Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 4, 2024 Category: Research Source Type: clinical trials

Combined HAIC, Lenvatinib and Cadonilimab as Conversion Therapy for Unresectable Hepatocellular Carcinoma
Conditions: Hepatocellular Carcinoma Non-resectable Interventions: Procedure: HAIC; Drug: Lenvatinib plus cadonilimab Sponsors: Tongji Hospital; Geneplus-Beijing Co. Ltd. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 3, 2024 Category: Research Source Type: clinical trials

HAIC Combined Sintilimab for Liver Metastasis From Esophageal Squamous Cell Carcinoma
Conditions: Hepatic Arterial Infusion Chemotherapy; Liver Metastases; Esophageal Squamous Cell Carcinoma Interventions: Drug: HAIC combined with intravenous PD-1 Sponsors: Peking University Cancer Hospital& Institute; Innovent Biologics (Suzhou) Co. Ltd. Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 28, 2023 Category: Research Source Type: clinical trials

CEUS vs. AMRI for HCC Detection in Patients With Indeterminate Liver Nodules
Conditions: HCC; Hepatocellular Carcinoma Interventions: Diagnostic Test: CEUS vs aMRI Sponsors: University of Texas Southwestern Medical Center; University of Michigan Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 28, 2023 Category: Research Source Type: clinical trials

A Study of Ga-68 Dolacga to Evaluate Liver Reserve Function in Patients With HCC Before and After Proton Therapy
Conditions: Hepatic Carcinoma Interventions: Drug: Ga-68 Dolacga Injection Sponsors: National Atomic Research Institute, Taiwan Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 27, 2023 Category: Research Source Type: clinical trials

Head-to-head Comparison of Positron Nuclide Radio-labeled FAPI and 18F-FDG PET/CT in Patients With Malignant Tumors
Conditions: Renal Cell Carcinoma; Gastric Cancer; Hepatocellular Carcinoma; Signet Ring Cell Carcinoma; Mucinous Adenocarcinoma; Colorectal Cancer Interventions: Diagnostic Test: FAPI PET/CT Sponsors: Guangdong Provincial People ' s Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 27, 2023 Category: Research Source Type: clinical trials

Prospective Cohort Study on Thermal Ablation of Malignant Liver Tumors
Conditions: Liver Cancer; Liver Metastases; Liver Metastasis Colon Cancer; Hepatocellular Carcinoma Sponsors: Leiden University Medical Center; Philips Healthcare; European Commission Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 22, 2023 Category: Research Source Type: clinical trials