Prognostic Markers for a Better Follow-up in Head and Neck Cancer.
Conditions: Head and Neck Cancer Interventions: Genetic: DNA exome sequencing of tumor and blood Sponsors: Karolinska Institutet Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 23, 2023 Category: Research Source Type: clinical trials

A Study to Test Different Doses of BI 765049 Alone and in Combination With Ezabenlimab in Asian People With Advanced Cancer (Solid Tumours) Positive for B7-H6
Conditions: Gastrointestinal Cancer; Lung Cancer; Pancreatic Cancer; Colorectal Cancer; Head and Neck Cancer; Liver Cancer Interventions: Drug: BI 765049; Drug: Ezabenlimab Sponsors: Boehringer Ingelheim Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 20, 2023 Category: Research Source Type: clinical trials

Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL)
Conditions: Head and Neck Cancer; Head and Neck Squamous Cell Carcinoma; Oropharynx Cancer; Oropharynx Squamous Cell Carcinoma; HPV Positive Oropharyngeal Squamous Cell Carcinoma Interventions: Other: Experimental Observation; Other: Observation per Standard of Care; Radiation: Adjuvant Treatment per Standard of Care; Diagnostic Test: Circulating Tumor DNA test (ctDNA test) Sponsors: University of Maryland, Baltimore Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 18, 2023 Category: Research Source Type: clinical trials

Dose Escalation Using Hypoxia-adjusted Radiotherapy
Conditions: Head and Neck Squamous Cell Carcinoma Interventions: Radiation: DE-HyART; Radiation: Standard Arm; Drug: Cisplatin injection; Radiation: Standard fractionation (Radiation Oncology preference) Sponsors: Rajiv Gandhi Cancer Institute& Research Center, India; Varian, a Siemens Healthineers Company Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 18, 2023 Category: Research Source Type: clinical trials

Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400
Conditions: Hepatocellular Carcinoma; Pancreatic Ductal Adenocarcinoma; Biliary Tract Cancers; Esophageal Squamous Cell Carcinoma; Triple Negative Breast Cancer; Hormone Receptor+/Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer; Head and Neck Squamous-Cell Carcinoma Interventions: Drug: ABBV-400 Sponsors: AbbVie Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 16, 2023 Category: Research Source Type: clinical trials

Testing the Addition of an Investigational Drug, Xevinapant, to Usual Radiation Therapy Plus Cisplatin/Carboplatin for Patients With Head and Neck Cancer
Conditions: Head and Neck Squamous Cell Carcinoma; Hypopharyngeal Squamous Cell Carcinoma; Laryngeal Squamous Cell Carcinoma; Oral Cavity Squamous Cell Carcinoma; Oropharyngeal Squamous Cell Carcinoma; Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8; Stage III Hypopharyngeal Carcinoma AJCC v8; Stage III Laryngeal Cancer AJCC v8; Stage III Lip and Oral Cavity Cancer AJCC v8; Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8; Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8; Stage IV Hypopharyngeal Carcinoma AJCC v8; Stage IV Laryngeal Cancer AJCC v8; Stage IV Lip and Or...
Source: ClinicalTrials.gov - October 16, 2023 Category: Research Source Type: clinical trials

An Exercise Prehabilitation Intervention for Improving Mobility and Recovery Outcomes in Patients Undergoing Head and Neck Cancer Surgery
Conditions: Head and Neck Carcinoma Interventions: Other: Electronic Health Record Review; Other: Exercise Intervention; Other: Medical Device Usage and Evaluation; Other: Survey Administration Sponsors: OHSU Knight Cancer Institute Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 12, 2023 Category: Research Source Type: clinical trials

Assessment of radio(chemo)therapy-related dysphagia in head and neck cancer patients based on cough-related acoustic features: a prospective phase II national clinical trial (ACCOUGH-P/A trial)
This study is expected to develop methods of acoustic cough analysis to enhance the assessment of radiation-associated dysphagia in head and neck cancer patients following (chemo)radiation.Trial registrationInternational Standard Randomized Controlled Trials Number (ISRCTN) registry ISRCTN16540497. Accepted on 23 June 2023. (Source: Trials)
Source: Trials - September 29, 2023 Category: Research Source Type: clinical trials

Phase 1b Safety Study of Xevinapant, Weekly Cisplatin, and RT in Participants With Unresected LA SCCHN (HyperlynX)
Conditions: Head and Neck Cancer Interventions: Drug: Xevinapant; Drug: Cisplatin; Radiation: intensity-modulated radiation therapy (IMRT) Sponsors: EMD Serono Research& Development Institute, Inc.; Merck KGaA, Darmstadt, Germany Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 27, 2023 Category: Research Source Type: clinical trials

Study of ALE.C04 in Patients With Head and Neck Cancer
Conditions:   Head and Neck Cancer;   Head and Neck Squamous Cell Carcinoma Interventions:   Drug: ALE.C04;   Drug: Pembrolizumab Sponsor:   Alentis Therapeutics AG Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 26, 2023 Category: Research Source Type: clinical trials

Study of ALE.C04 in Patients With Head and Neck Cancer
Conditions: Head and Neck Cancer; Head and Neck Squamous Cell Carcinoma Interventions: Drug: ALE.C04; Drug: Pembrolizumab Sponsors: Alentis Therapeutics AG Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 26, 2023 Category: Research Source Type: clinical trials

Study of BDC-3042 as Single Agent and in Combination With Pembrolizumab in Patients With Advanced Malignancies
Conditions: Triple Negative Breast Cancer; Clear Cell Renal Cell Carcinoma; Ovarian Cancer; Head and Neck Cancer; Colorectal Cancer; Non-small Cell Lung Cancer Interventions: Drug: BDC-3042; Drug: Pembrolizumab Sponsors: Bolt Biotherapeutics, Inc. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 25, 2023 Category: Research Source Type: clinical trials

Needs and Preferences of Patients With Head-neck Cutaneous SCC
Conditions:   Cutaneous Squamous Cell Carcinoma;   Cutaneous Squamous Cell Carcinoma of the Head and Neck;   Squamous Cell Carcinoma;   Squamous Cell Carcinoma of Head and Neck;   Squamous Cell Carcinoma of the Head and Neck;   Skin Cancer;   Patient Satisfaction;   High-Risk Cance r;   Preference, Patient;   Decision Making;   Interview Intervention:   Other: Regular care with additional administration of a semi-structured interview Sponsor:   Maastricht University Medical Center Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 21, 2023 Category: Research Source Type: clinical trials