Genomic survey maps differences in the molecular complement of vesicle formation machinery between < i > Giardia intestinalis < /i > assemblages
In this study, we explored the necessary machinery for the formation of vesicles and cargo transport in 89 Canadian isolates of assemblage A and BG.intestinalis. Considerable variability within the molecular complement of the endolysosomal ESCRT protein machinery, adaptor coat protein complexes, and ARF regulatory system have previously been reported. Here, we confirm inter-assemblage, but find no intra-assemblage variation within the trafficking systems examined. This variation includes losses of subunits belonging to the ESCRTIII as well as novel lineage specific duplications in components of the COPII machinery, ARF1, a...
Source: PLoS Neglected Tropical Diseases - December 18, 2023 Category: Tropical Medicine Authors: Shweta V. Pipaliya Source Type: research
Trends and clinico-epidemiological profile of patients with Giardiasis: Five-year experience from a university hospital of northern India
CONCLUSION: Awareness and knowledge amongst the primary healthcare professionals and family physicians will help in early diagnosis and treatment of Giardiasis. Fecal antigen detection should be done along with microscopy for detection of Giardiasis.PMID:38074244 | PMC:PMC10706534 | DOI:10.4103/jfmpc.jfmpc_2337_22 (Source: Primary Care)
Source: Primary Care - December 11, 2023 Category: Primary Care Authors: Nidhi Tejan Tasneem Siddiqui Pooja Singh Uday C Ghoshal Ujjala Ghoshal Source Type: research
Trends and clinico-epidemiological profile of patients with Giardiasis: Five-year experience from a university hospital of northern India
CONCLUSION: Awareness and knowledge amongst the primary healthcare professionals and family physicians will help in early diagnosis and treatment of Giardiasis. Fecal antigen detection should be done along with microscopy for detection of Giardiasis.PMID:38074244 | PMC:PMC10706534 | DOI:10.4103/jfmpc.jfmpc_2337_22 (Source: Primary Care)
Source: Primary Care - December 11, 2023 Category: Primary Care Authors: Nidhi Tejan Tasneem Siddiqui Pooja Singh Uday C Ghoshal Ujjala Ghoshal Source Type: research
Antigiardial and antiamebic activities of fexinidazole and its metabolites: new drug leads for giardiasis and amebiasis
Antimicrob Agents Chemother. 2023 Dec 8:e0073123. doi: 10.1128/aac.00731-23. Online ahead of print.ABSTRACTThe intestinal parasites Giardia lamblia and Entamoeba histolytica are major causes of morbidity and mortality associated with diarrheal diseases. Metronidazole is the most common drug used to treat giardiasis and amebiasis. Despite its efficacy, treatment failures in giardiasis occur in up to 5%-40% of cases. Potential resistance of E. histolytica to metronidazole is an increasing concern. Therefore, it is critical to search for more effective drugs to treat giardiasis and amebiasis. We identified antigiardial and an...
Source: Antimicrobial Agents and Chemotherapy - December 8, 2023 Category: Microbiology Authors: Jose Ignacio Escrig Yukiko Miyamoto Alejandro Delgado Aznar Lars Eckmann Anjan Debnath Source Type: research
Antigiardial and antiamebic activities of fexinidazole and its metabolites: new drug leads for giardiasis and amebiasis
Antimicrob Agents Chemother. 2023 Dec 8:e0073123. doi: 10.1128/aac.00731-23. Online ahead of print.ABSTRACTThe intestinal parasites Giardia lamblia and Entamoeba histolytica are major causes of morbidity and mortality associated with diarrheal diseases. Metronidazole is the most common drug used to treat giardiasis and amebiasis. Despite its efficacy, treatment failures in giardiasis occur in up to 5%-40% of cases. Potential resistance of E. histolytica to metronidazole is an increasing concern. Therefore, it is critical to search for more effective drugs to treat giardiasis and amebiasis. We identified antigiardial and an...
Source: Antimicrobial Agents and Chemotherapy - December 8, 2023 Category: Microbiology Authors: Jose Ignacio Escrig Yukiko Miyamoto Alejandro Delgado Aznar Lars Eckmann Anjan Debnath Source Type: research
Antigiardial and antiamebic activities of fexinidazole and its metabolites: new drug leads for giardiasis and amebiasis
Antimicrob Agents Chemother. 2023 Dec 8:e0073123. doi: 10.1128/aac.00731-23. Online ahead of print.ABSTRACTThe intestinal parasites Giardia lamblia and Entamoeba histolytica are major causes of morbidity and mortality associated with diarrheal diseases. Metronidazole is the most common drug used to treat giardiasis and amebiasis. Despite its efficacy, treatment failures in giardiasis occur in up to 5%-40% of cases. Potential resistance of E. histolytica to metronidazole is an increasing concern. Therefore, it is critical to search for more effective drugs to treat giardiasis and amebiasis. We identified antigiardial and an...
Source: Antimicrobial Agents and Chemotherapy - December 8, 2023 Category: Microbiology Authors: Jose Ignacio Escrig Yukiko Miyamoto Alejandro Delgado Aznar Lars Eckmann Anjan Debnath Source Type: research
Development of an LFD-RPA Assay for Rapid Detection of < em > Pentatrichomonas hominis < /em > Infection in Dogs
In conclusion, the LFD-RPA method developed in this study represents a simple and sensitive assay that allows for the rapid detection of P. hominis infection in dogs, especially in this field.PMID:37998756 | PMC:PMC10670101 | DOI:10.3390/cimb45110579 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Yao Rong Xichen Zhang Xuejiao Chen Jianhua Li Pengtao Gong Xiaocen Wang Xin Li Xu Zhang Taotao Yue Hongbo Zhang Xiaofei Zhou Nan Zhang Source Type: research
Development of an LFD-RPA Assay for Rapid Detection of < em > Pentatrichomonas hominis < /em > Infection in Dogs
In conclusion, the LFD-RPA method developed in this study represents a simple and sensitive assay that allows for the rapid detection of P. hominis infection in dogs, especially in this field.PMID:37998756 | PMC:PMC10670101 | DOI:10.3390/cimb45110579 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Yao Rong Xichen Zhang Xuejiao Chen Jianhua Li Pengtao Gong Xiaocen Wang Xin Li Xu Zhang Taotao Yue Hongbo Zhang Xiaofei Zhou Nan Zhang Source Type: research
Development of an LFD-RPA Assay for Rapid Detection of < em > Pentatrichomonas hominis < /em > Infection in Dogs
In conclusion, the LFD-RPA method developed in this study represents a simple and sensitive assay that allows for the rapid detection of P. hominis infection in dogs, especially in this field.PMID:37998756 | PMC:PMC10670101 | DOI:10.3390/cimb45110579 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Yao Rong Xichen Zhang Xuejiao Chen Jianhua Li Pengtao Gong Xiaocen Wang Xin Li Xu Zhang Taotao Yue Hongbo Zhang Xiaofei Zhou Nan Zhang Source Type: research
Development of an LFD-RPA Assay for Rapid Detection of < em > Pentatrichomonas hominis < /em > Infection in Dogs
In conclusion, the LFD-RPA method developed in this study represents a simple and sensitive assay that allows for the rapid detection of P. hominis infection in dogs, especially in this field.PMID:37998756 | PMC:PMC10670101 | DOI:10.3390/cimb45110579 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Yao Rong Xichen Zhang Xuejiao Chen Jianhua Li Pengtao Gong Xiaocen Wang Xin Li Xu Zhang Taotao Yue Hongbo Zhang Xiaofei Zhou Nan Zhang Source Type: research
Development of an LFD-RPA Assay for Rapid Detection of < em > Pentatrichomonas hominis < /em > Infection in Dogs
In conclusion, the LFD-RPA method developed in this study represents a simple and sensitive assay that allows for the rapid detection of P. hominis infection in dogs, especially in this field.PMID:37998756 | PMC:PMC10670101 | DOI:10.3390/cimb45110579 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Yao Rong Xichen Zhang Xuejiao Chen Jianhua Li Pengtao Gong Xiaocen Wang Xin Li Xu Zhang Taotao Yue Hongbo Zhang Xiaofei Zhou Nan Zhang Source Type: research
Development of an LFD-RPA Assay for Rapid Detection of < em > Pentatrichomonas hominis < /em > Infection in Dogs
In conclusion, the LFD-RPA method developed in this study represents a simple and sensitive assay that allows for the rapid detection of P. hominis infection in dogs, especially in this field.PMID:37998756 | PMC:PMC10670101 | DOI:10.3390/cimb45110579 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Yao Rong Xichen Zhang Xuejiao Chen Jianhua Li Pengtao Gong Xiaocen Wang Xin Li Xu Zhang Taotao Yue Hongbo Zhang Xiaofei Zhou Nan Zhang Source Type: research
Development of an LFD-RPA Assay for Rapid Detection of < em > Pentatrichomonas hominis < /em > Infection in Dogs
In conclusion, the LFD-RPA method developed in this study represents a simple and sensitive assay that allows for the rapid detection of P. hominis infection in dogs, especially in this field.PMID:37998756 | PMC:PMC10670101 | DOI:10.3390/cimb45110579 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Yao Rong Xichen Zhang Xuejiao Chen Jianhua Li Pengtao Gong Xiaocen Wang Xin Li Xu Zhang Taotao Yue Hongbo Zhang Xiaofei Zhou Nan Zhang Source Type: research
Development of an LFD-RPA Assay for Rapid Detection of < em > Pentatrichomonas hominis < /em > Infection in Dogs
In conclusion, the LFD-RPA method developed in this study represents a simple and sensitive assay that allows for the rapid detection of P. hominis infection in dogs, especially in this field.PMID:37998756 | PMC:PMC10670101 | DOI:10.3390/cimb45110579 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Yao Rong Xichen Zhang Xuejiao Chen Jianhua Li Pengtao Gong Xiaocen Wang Xin Li Xu Zhang Taotao Yue Hongbo Zhang Xiaofei Zhou Nan Zhang Source Type: research
Development of an LFD-RPA Assay for Rapid Detection of < em > Pentatrichomonas hominis < /em > Infection in Dogs
In conclusion, the LFD-RPA method developed in this study represents a simple and sensitive assay that allows for the rapid detection of P. hominis infection in dogs, especially in this field.PMID:37998756 | PMC:PMC10670101 | DOI:10.3390/cimb45110579 (Source: Current Issues in Molecular Biology)
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Yao Rong Xichen Zhang Xuejiao Chen Jianhua Li Pengtao Gong Xiaocen Wang Xin Li Xu Zhang Taotao Yue Hongbo Zhang Xiaofei Zhou Nan Zhang Source Type: research
