Genomic survey maps differences in the molecular complement of vesicle formation machinery between < i > Giardia intestinalis < /i > assemblages
In this study, we explored the necessary machinery for the formation of vesicles and cargo transport in 89 Canadian isolates of assemblage A and BG.intestinalis. Considerable variability within the molecular complement of the endolysosomal ESCRT protein machinery, adaptor coat protein complexes, and ARF regulatory system have previously been reported. Here, we confirm inter-assemblage, but find no intra-assemblage variation within the trafficking systems examined. This variation includes losses of subunits belonging to the ESCRTIII as well as novel lineage specific duplications in components of the COPII machinery, ARF1, a...
Source: PLoS Neglected Tropical Diseases - December 18, 2023 Category: Tropical Medicine Authors: Shweta V. Pipaliya Source Type: research
