Neuromodulation and Mindfulness Patients With AUD
Conditions: Alcohol Dependence Interventions: Device: Transcutaneous vagus nerve stimulation; Device: Closed-loop AM-tACS Sponsors: Charite University, Berlin, Germany; Medical School Berlin Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 13, 2024 Category: Research Source Type: clinical trials
Personalized, interdisciplinary patient pathway for cross-sector care of multimorbid patients (eliPfad trial): study protocol for a randomized controlled trial
DiscussionIf eliPfad leads to fewer readmissions, proves (cost-)effective, and lowers the treatment burden, it should be introduced as a new standard of care in the German healthcare system.Trial registrationThe trial was registered in the German Clinical Trials Registry (Deutsches Register Klinischer Studien (DRKS)) on 08/14/2023 under the IDDRKS00031500. (Source: Trials)
Source: Trials - March 11, 2024 Category: Research Source Type: clinical trials
EFFects of Exposure and Cognitive behavioral Therapy for chronic BACK pain ( “EFFECT-BACK”): study protocol for a randomized controlled trial
ConclusionThis study will be the first RCT to compare CBT and EXP in chronic back pain in a large sample, including patients from different care structures due to psychological and medical recruitment centers. By identifying and exploring potential predictors of symptom improvement in each treatment group, this study will contribute to enable a more individualized assignment to treatment modalities and thus improves the care situation for chronic back pain and helps to create a customized treatment program for subgroups of pain patients. If our findings confirm EXP to be an efficacious and efficient treatment concept, it s...
Source: Trials - March 11, 2024 Category: Research Source Type: clinical trials
Statistical analysis plan for the PRO B study: open-label, superiority randomised controlled trial of alarm-based patient-reported outcome monitoring in patients with metastatic breast cancer
ConclusionThis detailed SAP defines the main components of the statistical analysis for the PRO B study to assist the statistician and prevent bias in selecting analysis and reporting findings. Version 1 of the SAP was finalised on January 18, 2024.Trial registrationDRKS (German Clinical Trials Register)DRKS00024015. Registered on February 15, 2021. (Source: Trials)
Source: Trials - March 7, 2024 Category: Research Source Type: clinical trials
BlueRock Therapeutics Phase I Clinical Trial for Bemdaneprocel for Parkinson ’s Disease Continues to Show Positive Trends at 18 Months
Berlin, Germany and Cambridge, MA USA, March 6, 2024– Bayer AG and BlueRock Therapeutics LP, a clinical stage cell therapy company and wholly owned independently operated subsidiary of Bayer AG, announced today details of 18-month data from... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - March 6, 2024 Category: Pharmaceuticals Source Type: clinical trials
UV light-mediated corneal crosslinking as (lymph)angioregressive pretreatment to promote graft survival after subsequent high-risk corneal transplantation (CrossCornealVision): protocol for a multicenter, randomized controlled trial
DiscussionBased on preclinical and early pilot clinical evidence, we want to test the novel concept of temporary (lymph)angioregressive pretreatment of high-risk eyes by CXL to promote subsequent corneal graft survival. So far, there is no evidence-based approach to reliably improve graft survival in the high-risk corneal transplantation setting available in clinical routine. If successful, this approach will be the first to promote graft survival in high-risk transplants. It will significantly improve vision and quality of life in patients suffering from corneal blindness.Trial registrationClinicalTrials.gov NCT05870566. ...
Source: Trials - March 6, 2024 Category: Research Source Type: clinical trials
Effectiveness of Intermittent Vacuum Therapy Combined With Aerobic Exercise in Individuals With Diabetes Mellitus
Conditions: Diabetes Mellitus Interventions: Device: Intermittent vacuum therapy (Weyergans High Care ® Medial, Germany) Sponsors: The Hong Kong Polytechnic University; Yan Chai Hospital Social Services Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 5, 2024 Category: Research Source Type: clinical trials
Endoscopic Versus Robotic Myotomy for Treatment of Achalasia
Conditions: Achalasia Cardia Interventions: Procedure: Robotic Heller Myotomy; Procedure: Peroral Endoscopic Myotomy Sponsors: Germans Trias i Pujol Hospital Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 4, 2024 Category: Research Source Type: clinical trials
Night Shift Work and Biomarkers of Obesity Risk in Hospital and Industry Workers
Conditions: Obesity; Shift-work Disorder; Circadian Rhythm Disorders Interventions: Other: No intervention Sponsors: University of Vienna; Medical University of Vienna; FH Joanneum Gesellschaft mbH; Wageningen University and Research; Wageningen University; University of Bremen; Verein zur F örderung des Technologietransfers an der Hochschule Bremerhaven e.V.; UNIVERSYTET MEDYCZNY W LODZI; Københavns Universitet; Charite University, Berlin, Germany; Erasmus Medical Center Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 1, 2024 Category: Research Source Type: clinical trials
Prevalence and Impact of Pertussis and RSV on Asthma Severity and Control
Conditions: Asthma; Pertussis; RSV Infection Interventions: Diagnostic Test: PCR Sponsors: Hospital Clinico Universitario de Santiago; Translational Research In Airway Diseases Group (TRIAD)-Santiago de Compostela; CIBER of Respiratory Diseases CIBERES, Madrid; Complexo Hospitalario Universitario de A Coru ña; Hospital de Galdakao; Hospital Universitario Doctor Peset; Hospital San Pedro de Alcantara; Hospital Universitario Marqués de Valdecilla; Hospital Universitario Vall d´Hebron; Universitat Autonoma de Barcelona; Universidade de Santiago de Compostela; Consortium for Biomedical Research in Epid emiology and Public H...
Source: ClinicalTrials.gov - February 29, 2024 Category: Research Source Type: clinical trials
Clinical Impact Through AI-assisted MS Care - A Retrospective Multi-center Observational Study.
Conditions: Multiple Sclerosis; NMO Spectrum Disorder; Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease; Radiologically Isolated Syndrome; Clinically Isolated Syndrome Sponsors: icometrix; Charite University, Berlin, Germany; Ruhr University of Bochum; Technische Universit ät Dresden; University Hospital, Lille; Casa di Cura IGEA; General University Hospital, Prague; Hoffmann-La Roche; Bristol-Myers Squibb; Imcyse SA; AB Science; Nocturne UG; Aalto University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 28, 2024 Category: Research Source Type: clinical trials
Intravenous Fish Oil Based Lipid Emulsion to Enhance Recovery in High-Risk Cardiac Surgery Patients.
Conditions: Cardiac Surgery; High Risk Patients; Intensive Care Unit; Cardiopulmonary Bypass; Valve Surgeries Interventions: Drug: Long-chain n-3 fatty acids; Drug: Intravenous 0.9% Sodium Chloride Sponsors: GCP-Service International West GmbH; Charite University, Berlin, Germany; Wuerzburg University Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 28, 2024 Category: Research Source Type: clinical trials
Bayer Receives U.S. FDA Breakthrough Therapy Designation for BAY 2927088 for Non-Small Cell Lung Cancer Harboring HER2 Activating Mutations
Berlin, Germany, February 26, 2024– Bayer announced today that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy designation for BAY 2927088 for the treatment of adult patients with unresectable or metastatic... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - February 26, 2024 Category: Pharmaceuticals Source Type: clinical trials
DivAirCity Social Health Survey
Conditions: Psychological Stress; Psychological Well-Being; Pollution; Exposure Interventions: Other: Air pollution and noise reducing installations Sponsors: Charite University, Berlin, Germany; Universitat Polit ècnica de València; Universitatea din Bucuresti; University of Aarhus; Fondazione C.N.R./Regione Toscana " G. Monasterio " , Pisa, Italy; European Commission Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 23, 2024 Category: Research Source Type: clinical trials
PAIN2.0: study protocol for a multicentre randomised controlled trial to evaluate the efficacy of a 10-week outpatient interdisciplinary multimodal pain therapy to manage recurrent pain for patients with risk factors of developing chronic pain in Germany
DiscussionRecurrent or persistent pain is common in the German population and causes high costs for patients and society. The A-IMPT aims to improve pain and pain-related impairments in pain patients at risk of chronification, thereby reducing the risk of developing chronic pain with its high socioeconomic burden. This new therapy could easily be integrated into existing therapy programs if positively evaluated.Trial registrationThe trial PAIN2.0 has been registered in the German Clinical Trials Register (DRKS) since 21/11/2022 with the IDDRKS00030773. (Source: Trials)
Source: Trials - February 23, 2024 Category: Research Source Type: clinical trials
