Clinical-grade Garcinia cambogia extract dissolves calcium oxalate crystals in Drosophila kidney stone models.
CONCLUSIONS: Garcinia cambogia extract removes calcium oxalate kidney stones from Drosophila Malpighian tubules via directly dissolving calcium oxalate stones by HCA. Our study strongly suggests that clinical-grade Garcinia cambogia extract could be used to treat patients with nephrolithiasis in the future. PMID: 32572941 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - June 25, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

New bioanalytical method for the quantification of (-) – hydroxycitric acid in human plasma using UPLC-MS/MS and its application in a Garcinia cambogia pharmacokinetic study
Publication date: Available online 23 May 2020Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Alessandro de Carvalho Cruz, Eunice Mayumi Suenaga, Shamina Saiyara Prova, Jerônimo Raimundo de Oliveira Neto, Demian Rocha Ifa, Luiz Carlos da Cunha (Source: Journal of Pharmaceutical and Biomedical Analysis)
Source: Journal of Pharmaceutical and Biomedical Analysis - May 24, 2020 Category: Drugs & Pharmacology Source Type: research

Rapid and cost-effective LC-MS/MS method for determination of hydroxycitric acid in plasma: Application in the determination of pharmacokinetics in commercial Garcinia preparations.
Abstract Garcinia cambogia is one of the most commonly used anti-obesity dietary supplements and hydroxycitric acid (HCA) is a major constituent in the commercial preparations of Garcinia. High doses of HCA are often consumed without much awaremess of its pharmacokinetic and toxicokinetic parameters, and hence a full understanding of HCA effects is lacking. The first step in understanding of these parameters is the availability of a reliable bioanalytical method. Herein, we present the first report on a UPLC-MS/MS method for analysis of HCA in rat plasma after simplified and cost-effective protein precipitation. C...
Source: Biomedical Chromatography : BMC - May 19, 2020 Category: Biomedical Science Authors: Bhutani P, U R, Shivakumar HN, Prabhakar KR, Paul AT Tags: Biomed Chromatogr Source Type: research

Molecules, Vol. 25, Pages 1894: The Anti-Inflammatory and Antimicrobial Potential of Selected Ethnomedicinal Plants from Sri Lanka
inghe Andreas Koeberle Oliver Werz Traditional folk medicine in Sri Lanka is mostly based on plants and plant-derived products, however, many of these medicinal plant species are scientifically unexplored. Here, we evaluated the anti-inflammatory and antimicrobial potency of 28 different extracts prepared from seven popular medicinal plant species employed in Sri Lanka. The extracts were subjected to cell-based and cell-free assays of 5-lipoxygenase (5-LO), microsomal prostaglandin E2 synthase (mPGES)-1, and nitric oxide (NO) scavenging activity. Moreover, antibacterial and disinfectant activities were assessed. Ch...
Source: Molecules - April 20, 2020 Category: Chemistry Authors: Mayuri Napagoda Jana Gerstmeier Hannah Butschek Sudhara De Soyza Simona Pace Sybille Lorenz Mallique Qader Sanjeeva Witharana Ajith Nagahawatte Gaya Wijayaratne Ale š Svatoš Lalith Jayasinghe Andreas Koeberle Oliver Werz Tags: Article Source Type: research

Hepatotoxicity associated with Garcinia cambogia: A case report.
CONCLUSION: Medical reconciliation of HS should be performed in patients with suspected acute liver failure and early discontinuation of HS can prevent further progression of drug induced hepatoxicity. PMID: 31772720 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - November 28, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Ocular complications of Garcinia cambogia extract diet pills: Case report.
CONCLUSION: It is necessary that physicians dealing with obesity advice patients about possible visual disturbance of this extract when taken in overdose so that they can see an ophthalmologist immediately. PMID: 31578090 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - October 3, 2019 Category: Opthalmology Authors: Cho HK, Han YS, Park JM Tags: Eur J Ophthalmol Source Type: research

Preparation and preliminary pharmacokinetics study of GNA ‐loaded zein nanoparticles
ConclusionGNA ‐ZN‐NPs significantly enhanced the oral bioavailability and prolonged half‐life of GNA, providing a promising oral drug delivery system to improvein vivo pharmacokinetic behaviour of GNA. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - August 29, 2019 Category: Drugs & Pharmacology Authors: Weiye Cheng, Beilei Wang, Caiyun Zhang, Qiannian Dong, Jiajia Qian, Liqiong Zha, Weidong Chen, Lufeng Hong Tags: Research Paper Source Type: research

Acute liver failure associated with Garcinia cambogia use.
We report a case of acute liver failure requiring liver transplantation associated with the use of Garcinia cambogia, a supplement widely promoted for weight loss. When patients present with acute hepatitis or liver failure from an unknown etiology, a careful history of supplement use should be performed. PMID: 31320156 [PubMed] (Source: Annals of Hepatology)
Source: Annals of Hepatology - July 22, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Short-term effects of Garcinia cambogia extract on the pharmacokinetics of lamotrigine given as a single-dose in Wistar rats.
ves G Abstract Garcinia cambogia supplements are widely used for weight loss. Knowing that epilepsy patients are at greater risk of developing overweight/obesity, the investigation of herb-drug interactions involving antiepileptic drugs of narrow therapeutic index is fully justified. This work was planned to assess potential pharmacokinetic-based interactions between G. cambogia extract and lamotrigine (LTG) through two independent pharmacokinetic studies. In the first study (co-administration study), rats were orally co-administered with a single-dose of G. cambogia extract (821 mg/kg) and LTG (10 mg/kg). In ...
Source: Food and Chemical Toxicology - March 30, 2019 Category: Food Science Authors: Ventura S, Rodrigues M, Falcão A, Alves G Tags: Food Chem Toxicol Source Type: research

Evidence for the efficacy and safety of herbal weight loss preparations
Publication date: Available online 30 January 2019Source: Journal of Integrative MedicineAuthor(s): Rachael Farrington, Ian F. Musgrave, Roger W. ByardAbstractRising rates of obesity across the globe have been associated with an increase in the use of herbal preparations for weight control. However, the mechanisms of action for these substances are often not known, as is the potential for interaction with other herbal preparations or prescription pharmaceutical drugs. To investigate the reported efficacy and safety of herbal weight loss preparations, we conducted a review of the literature focusing on herbs that are most c...
Source: Journal of Integrative Medicine - January 31, 2019 Category: Complementary Medicine Source Type: research

Raspberry ketone and Garcinia Cambogia rebalanced disrupted insulin resistance and leptin signaling in rats fed high fat fructose diet
ConclusionOur study highlights the involvement ofp-IRS-1/p-Akt/GLUT-4, leptin/STAT-3 and SREBP-1c signaling trajectories in the beneficial combination of GC and RK, besides, the efficient rebalance of the redox status, insulin resistance and tissue fat deposition confirmed histopathologically.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 7, 2018 Category: Drugs & Pharmacology Source Type: research

Raspberry ketone and Garcinia Cambogia rebalanced disrupted insulin resistance and leptin signaling in rats fed high fat fructose diet.
CONCLUSION: Our study highlights the involvement ofp-IRS-1/p-Akt/GLUT-4, leptin/STAT-3 and SREBP-1c signaling trajectories in the beneficial combination of GC and RK, besides, the efficient rebalance of the redox status, insulin resistance and tissue fat deposition confirmed histopathologically. PMID: 30530230 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 6, 2018 Category: Drugs & Pharmacology Authors: Attia RT, Abdel-Mottaleb Y, Abdallah DM, El-Abhar HS, El-Maraghy NN Tags: Biomed Pharmacother Source Type: research

Screening of microalgae for treating Garcinia cambogia wash water with potential lipid production.
Abstract The microalgae-based water treatment is gaining importance in recent years as it serves multiple purposes of which includes water treatment and biofuel production. Garcinia cambogia, a Malabar tamarind is a tropical fruit and the active ingredient hydroxycitric acid is popularly used as a weight-loss supplement. After extraction of the hydroxycitric acid, the wash water of G. cambogia is considered as an effluent. The potential microalgal species that can grow and treat G. cambogia wash water were isolated and identified as Dicloster acuatus BVR1 and Kalenjenia gelanitosa BVR2. Both the microalgal species...
Source: Environmental Science and Pollution Research International - June 29, 2018 Category: Environmental Health Authors: Budhi Venkatesan R, Rajarathinam R Tags: Environ Sci Pollut Res Int Source Type: research

Chrysanthemum indicum L. ethanol extract reduces high-fat diet-induced obesity in mice.
Authors: Cha JY, Nepali S, Lee HY, Hwang SW, Choi SY, Yeon JM, Song BJ, Kim DK, Lee YM Abstract The present study was undertaken to investigate the mechanism behind the anti-obesity effect of the 50% ethanol extract of Chrysanthemum indicum L. flowers (CIEE) in a mouse model of high-fat diet (HFD)-induced obesity. Male C57BL/6J mice (six mice in each group) were administered CIEE (8, 40 and 200 mg/kg) for 6 weeks while being fed with a HFD. Garcinia cambogia (GC) was used as the positive control and was administered in the same manner as CIEE. Results demonstrated that oral administration of CIEE significantly redu...
Source: Experimental and Therapeutic Medicine - June 2, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Desalted Salicornia europaea powder and its active constituent, trans-ferulic acid, exert anti-obesity effects by suppressing adipogenic-related factors.
CONCLUSIONS: These findings suggest that DSP may be considered for use as a food supplement intent of controlling obesity through its antiobesity and antiadipogenic properties. PMID: 29521146 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - March 10, 2018 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Evaluation of Natural Product Compositions for Appetite Suppression.
Authors: Yimam M, Jiao P, Hong M, Brownell L, Lee YC, Hyun EJ, Kim HJ, Kim TW, Nam JB, Kim MR, Jia Q Abstract A change in homeostasis between food intake and energy expenditure is the hallmark of obesity. Many plant-based weight-management products are available in dietary supplement markets with no direct efficacy comparison. In this in vivo acute feed intake study in rats, the appetite suppression efficacy of well-known natural ingredients in the weight-loss market were evaluated. We tested pure caffeine, potato skin extract, Cissus quadrangularis extract, Garcinia cambogia extract, Crocus sativus extract, raspbe...
Source: Journal of Dietary Supplements - February 15, 2018 Category: Nutrition Tags: J Diet Suppl Source Type: research

Long-term effects of Garcinia cambogia/Glucomannan on weight loss in people with obesity, PLIN4, FTO and Trp64Arg polymorphisms
Overweight and obesity are considered major health problems that contribute to increase mortality and quality of life. Both conditions have a high prevalence across the world reaching epidemic numbers. Our aim... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - January 24, 2018 Category: Complementary Medicine Authors: Andrea Maia-Landim, Juan M. Ram írez, Carolina Lancho, María S. Poblador and José L. Lancho Tags: Research article Source Type: research

Anti ‑inflammatory effects of gambogic acid in murine collagen‑induced arthritis through PI3K/Akt signaling pathway.
Anti‑inflammatory effects of gambogic acid in murine collagen‑induced arthritis through PI3K/Akt signaling pathway. Mol Med Rep. 2018 Jan 08;: Authors: Wang QL, Yang DZ, Lv C Abstract Garcinia angustifolia is a dry resin secreted by Garcinia cambogia, which has the functions of breaking blood, detoxifying, stopping bleeding and killing insects. It is used for the treatment of cancer and brain edema. Gambogic acid is the primary active ingredient. The present study aimed to investigate the anti‑inflammatory and antiproliferative effects of gambogic acid on arthritis and the possible mechanisms. It...
Source: Molecular Medicine Reports - January 14, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Garcinia cambogia for weight loss.
PMID: 29317394 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - January 11, 2018 Category: Drugs & Pharmacology Authors: Haber SL, Awwad O, Phillips A, Park AE, Pham TM Tags: Am J Health Syst Pharm Source Type: research

Chrysanthemum indicum Inhibits Adipogenesis and Activates the AMPK Pathway in High-Fat-Diet-Induced Obese Mice.
Abstract Chrysanthemum indicum (CI) is widely distributed in China and many parts of the tropical world, and has been reported to have antibacterial, antiviral, anti-oxidant and immunomodulatory effects, but no information is available on its effects on high fat diet (HFD)-induced obesity. This was undertaken to investigate the mechanism responsible for the effect of ethyl acetate fraction of CI (CIEA) on adipogenesis, in vitro and in vivo models of obesity. In the in vitro study, differentiating 3T3-L1 cells were treated with media to initiate differentiation (MDI) in the presence or absence of CIEA with differen...
Source: The American Journal of Chinese Medicine - January 3, 2018 Category: Complementary Medicine Authors: Nepali S, Cha JY, Ki HH, Lee HY, Kim YH, Kim DK, Song BJ, Lee YM Tags: Am J Chin Med Source Type: research

Binding of hydroxycitrate to human ATP-citrate lyase
Hydroxycitrate from the fruit of Garcinia cambogia [i.e. (2S,3S)-2-hydroxycitrate] is the best-known inhibitor of ATP-citrate lyase. Well diffracting crystals showing how the inhibitor binds to human ATP-citrate lyase were grown by modifying the protein. The protein was modified by introducing cleavage sites for Tobacco etch virus protease on either side of a disordered linker. The protein crystallized consisted of residues 2 – 425-ENLYFQ and S-488 – 810 of human ATP-citrate lyase. (2S,3S)-2-Hydroxycitrate binds in the same orientation as citrate, but the citrate-binding domain (residues 248 – 421) adopts...
Source: Acta Crystallographica Section D - July 28, 2017 Category: Biochemistry Authors: Hu, J. Komakula, A. Fraser, M.E. Tags: ATP-citrate lyase hydroxycitrate domain movement TEV cleavage disorder linker affinity crystallography enzyme kinetics inhibition constants research papers Source Type: research

Low temperature, one-pot green synthesis of tailored carbon nanostructures/reduced graphene oxide composites and its investigation for supercapacitor application
Publication date: 1 July 2017 Source:Materials Letters, Volume 198 Author(s): Arthi Gopalakrishnan, Parikshit Sahatiya, Sushmee Badhulika In this paper, we explore a novel, one-step, economic, facile and eco-friendly route to synthesize in-situ tailored carbon nanostructures such as carbon nanorods (CNR) and carbon nanospheres (CNS) with reduced graphene oxide using tamarind extract (Garcinia Cambogia) by temperature dependent hydrothermal process under alkaline conditions for supercapacitor applications. FESEM analyses revealed the reduction of GO at 180°C and formation of carbon nanostructures at relatively lower te...
Source: Materials Letters - April 11, 2017 Category: Materials Science Source Type: research

Anti-obesity effect of Solidago virgaurea var. gigantea extract through regulation of adipogenesis and lipogenesis pathways in high-fat diet-induced obese mice (C57BL/6N).
Conclusion: SV10E can be a potent functional food ingredient for preventing HFD-induced obesity by suppressing adipogenesis and lipogenesis. PMID: 28326002 [PubMed - in process] (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - March 24, 2017 Category: Nutrition Authors: Wang Z, Kim JH, Jang YS, Kim CH, Lee JY, Lim SS Tags: Food Nutr Res Source Type: research

A Paper-Based Colorimetric Assay for the Detection of Hg(II) in Aqueous Solutions Using Silver Nanoparticles Green Synthesized with Garcinia cambogia and Their Application for Environmental Samples
(Source: Sensor Letters)
Source: Sensor Letters - March 23, 2017 Category: Medical Equipment Authors: George, Santhi M. Senthilnathan, T. Tags: Research Articles Source Type: research

Inhibitory Effects of Garcinia cambogia Extract on CYP2B6 Enzyme Activity
This study assessed the inhibitory effects of Garcinia cambogia extract on the cytochrome P450 enzymes in vitro. G. cambogia extract was incubated with cytochrome P450 isozyme-specific substrates in human liver microsomes and recombinant CYP2B6 isozyme, and the formation of the marker metabolites was measured to investigate the inhibitory potential on cytochrome P450 enzyme activities. The results showed that G. cambogia extract has significant inhibitory effects on CYP2B6 activity in a concentration-dependent manner. Furthermore, the inhibition was potentiated following preincubation with NADPH, indicating that G. cambogi...
Source: Planta Medica - March 13, 2017 Category: Drugs & Pharmacology Authors: Yu, Jun Sang Choi, Min Sun Park, Jong Suk Rehman, Shaheed Ur Nakamura, Katsunori Yoo, Hye Hyun Tags: Original Papers Source Type: research

Phytochemical compounds in sport nutrition: Synephrine and hydroxycitric acid (HCA) as examples for evaluation of possible health risks
This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - March 1, 2017 Category: Nutrition Authors: Nadiya Bakhiya, Rainer Ziegenhagen, Karen I. Hirsch ‐Ernst, Birgit Dusemund, Klaus Richter, Katharina Schultrich, Sophie Pevny, Bernd Schäfer, Alfonso Lampen Tags: Review Source Type: research

Enzyme-treated Ecklonia cava extract inhibits adipogenesis through the downregulation of C/EBP α in 3T3-L1 adipocytes.
In this study, we examined the inhibitory effects of enzyme- treated Ecklonia cava (EEc) extract on the adipogenesis of 3T3-L1 adipocytes. The components of Ecklonia cava (E. cava) were first separated and purified using the digestive enzymes pectinase (Rapidase® X‑Press L) and cellulase (Rohament® CL). We found that the EEc extract contained three distinct phlorotannins: eckol, dieckol and phlorofucofuroeckol-A. Among the phlorotannins, dieckol was the most abundant in the EEc extract at 16 mg/g. Then we examined the inhibitory effects of EEc extract treatment on differentiation‑related tra...
Source: International Journal of Molecular Medicine - January 26, 2017 Category: Molecular Biology Authors: Kim IH, Nam TJ Tags: Int J Mol Med Source Type: research

Dangerous dietary supplements: Garcinia cambogia-associated hepatic failure requiring transplantation.
Abstract Commercial dietary supplements are marketed as a panacea for the morbidly obese seeking sustainable weight-loss. Unfortunately, many claims cited by supplements are unsupported and inadequately regulated. Most concerning, however, are the associated harmful side effects, often unrecognized by consumers. Garcinia cambogia extract and Garcinia cambogia containing products are some of the most popular dietary supplements currently marketed for weight loss. Here, we report the first known case of fulminant hepatic failure associated with this dietary supplement. One active ingredient in this supplement is hyd...
Source: World Journal of Gastroenterology : WJG - December 7, 2016 Category: Gastroenterology Authors: Lunsford KE, Bodzin AS, Reino DC, Wang HL, Busuttil RW Tags: World J Gastroenterol Source Type: research

Identification and quantification of adulteration in Garcinia cambogia commercial products by chromatographic and spectrometric methods
. (Source: Food Additives and Contaminants Part A)
Source: Food Additives and Contaminants Part A - October 19, 2016 Category: Food Science Authors: Nargis Jamila Ji Yeon Choi Joon Ho Hong Eun Yeong Nho Naeem Khan Cheon Ho Jo Hyang Sook Chun Kyong Su Kim Source Type: research

Hypomania induced by a Garcinia cambogia supplement.
PMID: 27630171 [PubMed - as supplied by publisher] (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - September 14, 2016 Category: Psychiatry Authors: Cotovio G, Oliveira-Maia AJ Tags: Aust N Z J Psychiatry Source Type: research

Optical Sensing of Mercury(II) by Green-Synthesized Silver Nanoparticles Prepared Using Garcinia cambogia and Their Application in Real Water Sample Analysis
(Source: Sensor Letters)
Source: Sensor Letters - August 24, 2016 Category: Medical Equipment Authors: George, Santhi M. Senthilnathan, T. Tags: Research Articles Source Type: research

Mania Induced by Garcinia cambogia: A Case Series.
Authors: Hendrickson BP, Shaikh N, Occhiogrosso M, Penzner JB PMID: 27486540 [PubMed - in process] (Source: The Primary Care Companion for CNS Disorders)
Source: The Primary Care Companion for CNS Disorders - August 5, 2016 Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research

Nutrition Supplements to Stimulate Lipolysis: A Review in Relation to Endurance Exercise Capacity.
Authors: Kim J, Park J, Lim K Abstract Athletes make great efforts to increase their endurance capacity in many ways. Using nutrition supplements for stimulating lipolysis is one such strategy to improve endurance performance. These supplements contain certain ingredients that affect fat metabolism; furthermore, in combination with endurance training, they tend to have additive effects. A large body of scientific evidence shows that nutrition supplements increase fat metabolism; however, the usefulness of lipolytic supplements as ergogenic functional foods remains controversial. The present review will describe the...
Source: Journal of Nutritional Science and Vitaminology - July 30, 2016 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

( ‐)‐Hydroxycitric Acid Nourishes Protein Synthesis via Altering Metabolic Directions of Amino Acids in Male Rats
(‐)‐Hydroxycitric acid (HCA), a major active ingredient of Garcinia Cambogia extracts, had shown to suppress body weight gain and fat accumulation in animals and humans. While, the underlying mechanism of (‐)‐HCA has not fully understood. Thus, this study was aimed to investigate the effects of long‐term supplement with (‐)‐HCA on body weight gain and variances of amino acid content in rats. Results showed that (‐)‐HCA treatment reduced body weight gain and increased feed conversion ratio in rats. The content of hepatic glycogen, muscle glycogen, and serum T4, T3, insulin, and Leptin were increased in (...
Source: Phytotherapy Research - May 4, 2016 Category: Biochemistry Authors: Ningning Han, Longlong Li, Mengling Peng, Haitian Ma Tags: Research Article Source Type: research

(‐)‐Hydroxycitric Acid Nourishes Protein Synthesis via Altering Metabolic Directions of Amino Acids in Male Rats
(‐)‐Hydroxycitric acid (HCA), a major active ingredient of Garcinia Cambogia extracts, had shown to suppress body weight gain and fat accumulation in animals and humans. While, the underlying mechanism of (‐)‐HCA has not fully understood. Thus, this study was aimed to investigate the effects of long‐term supplement with (‐)‐HCA on body weight gain and variances of amino acid content in rats. Results showed that (‐)‐HCA treatment reduced body weight gain and increased feed conversion ratio in rats. The content of hepatic glycogen, muscle glycogen, and serum T4, T3, insulin, and Leptin were increased in (...
Source: Phytotherapy Research - May 1, 2016 Category: Biochemistry Authors: Ningning Han, Longlong Li, Mengling Peng, Haitian Ma Tags: Research Article Source Type: research

New Dietary Supplements for Obesity: What We Currently Know
Abstract Obesity and its associated cardiometabolic alterations currently are considered an epidemic; thus, their treatment is of major importance. The cornerstone for such treatment involves therapeutic lifestyle changes; however, the vast majority of cases fail and/or significant weight loss is maintained only in the short term because of lack of compliance. The popularity of dietary supplements for weight management has increased, and a wide variety of these products are available over the counter. However, the existing scientific evidence is insufficient to recommend their safe use. Hence, the purpose of this ...
Source: Current Obesity Reports - April 6, 2016 Category: Eating Disorders and Weight Management Source Type: research

Anti-obesity effect of extract from fermented Curcuma longa L. through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats.
CONCLUSIONS: These results suggest that FCE50 can be a candidate for the prevention of obesity via suppressing adipogenesis and promoting lipolysis. PMID: 26822962 [PubMed] (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - January 31, 2016 Category: Nutrition Authors: Kim JH, Kim OK, Yoon HG, Park J, You Y, Kim K, Lee YH, Choi KC, Lee J, Jun W Tags: Food Nutr Res Source Type: research

The effect of garcinia cambogia as coadjuvant in the weight loss process.
CONCLUSION: studies suggest positive results about the effectiveness of the GC on the weight loss process. However, the ideal dosage has not been well established yet. There is little evidence of adverse effects and signs of protective effect against hepatotoxicity induced by ethanol. Therefore, it becomes necessary to carry out further studies to confirm the efficacy of this phytotherapy in the weight loss process. PMID: 26667686 [PubMed - as supplied by publisher] (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - December 18, 2015 Category: Nutrition Authors: Fassina P, Scherer Adami F, Terezinha Zani V, Kasper Machado IC, Garavaglia J, Quevedo Grave MT, Ramos R, Morelo Dal Bosco S Tags: Nutr Hosp Source Type: research

Effects of intraduodenal hydroxycitrate on glucose absorption, incretin release, and glycemia in response to intraduodenal glucose infusion in health and type 2 diabetes: A randomised controlled trial
Hydroxycitric acid (HCA), derived from the fruit Garcinia cambogia, reduces the rate of glucose absorption and lowers postprandial glycemia in rodents, but its effect in humans is unknown. The aim of this study was to investigate the effects of small intestinal perfusion with HCA on glucose absorption, as well as the incretin and glycemic responses to a subsequent intraduodenal glucose infusion, in both healthy individuals and patients with type 2 diabetes. (Source: Nutrition)
Source: Nutrition - December 7, 2015 Category: Nutrition Authors: Sony S. Thazhath, Tongzhi Wu, Michelle J. Bound, Helen L. Checklin, Scott Standfield, Karen L. Jones, Michael Horowitz, Christopher K. Rayner Tags: Applied nutritional investigation Source Type: research

Effects of intraduodenal hydroxycitrate on glucose absorption, incretin release and glycemia in response to intraduodenal glucose infusion in health and type 2 diabetes – a randomised controlled trial (NUT-D-15-00649 revised version)
Hydroxycitric acid (HCA), derived from the fruit Garcinia cambogia, reduces the rate of glucose absorption and lowers postprandial glycemia in rodents, but its effect in humans is unknown. (Source: Nutrition)
Source: Nutrition - December 7, 2015 Category: Nutrition Authors: Sony S. Thazhath, Tongzhi Wu, Michelle J. Bound, Helen L. Checklin, Scott Standfield, Karen L. Jones, Michael Horowitz, Christopher K. Rayner Source Type: research

Acute liver failure associated with Garcinia cambogia use.
We report a case of acute liver failure requiring liver transplantation associated with the use of Garcinia cambogia, a supplement widely promoted for weight loss. When patients present with acute hepatitis or liver failure from an unknown etiology, a careful history of supplement use should be performed. PMID: 26626648 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - December 6, 2015 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Antihyperlipidemic and antioxidant activities of the ethanolic extract of Garcinia cambogia on high fat diet-fed rats
Authors: Sripradha, Ramalingam / Sridhar, Magadi Gopalakrishna / Maithilikarpagaselvi, Nachimuthu (Source: Journal of Complementary and Integrative Medicine)
Source: Journal of Complementary and Integrative Medicine - November 21, 2015 Category: Complementary Medicine Source Type: research

Acute Hepatitis Induced by Pure Garcinia cambogia
No abstract available (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 10, 2015 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

A comprehensive scientific overview of Garcina cambogia.
Abstract The fruit rind of Garcinia gummi-gutta, commonly known as Garcinia cambogia (syn.), is extensively used traditionally as a flavourant in fish curries due to its sharp sour taste. Additional ethnobotanical uses include its use as a digestive and a traditional remedy to treat bowel complaints, intestinal parasites and rheumatism. This small fruit, reminiscent of a pumpkin in appearance, is currently most popularly used and widely advertised as a weight-loss supplement. Studies have shown that the extracts as well as (-)-hydroxycitric acid (HCA), a main organic acid component of the fruit rind, exhibited ant...
Source: Fitoterapia - February 27, 2015 Category: Biochemistry Authors: Semwal RB, Semwal DK, Vermaak I, Viljoen A Tags: Fitoterapia Source Type: research

Determination of toxic metals by ICP-MS in Asiatic and European medicinal plants and dietary supplements
Publication date: Available online 4 November 2014 Source:Journal of Trace Elements in Medicine and Biology Author(s): A. Filipiak-Szok , M. Kurzawa , E. Szłyk The potentially toxic metals content was determined in selected plants, used in Traditional Chinese Medicine (Angelica sinensis, Bacopa monnieri, Bupleurum sinensis, Curcuma longa, Cola accuminata, Emblica officinalis, Garcinia cambogia, Mucuna pruriens, Ocimum sanctum, Panax ginseng, Pueraria lobata, Salvia miltiorrhiza, Schisandra sinensis, Scutellaria baicalensis, Siraitia grosvenorii, Terminalia arjuna and Terminalia chebula), and some European herbs (Echinac...
Source: Journal of Trace Elements in Medicine and Biology - November 9, 2014 Category: Biochemistry Source Type: research

IQP‐GC‐101 Reduces Body Weight and Body Fat Mass: A Randomized, Double‐Blind, Placebo‐Controlled Study
IQP‐GC‐101 is a patented blend of the standardized extracts of Garcinia cambogia, Camellia sinensis, unroasted Coffea arabica, and Lagerstroemia speciosa. These individual ingredients of IQP‐GC‐101 have each shown promise in promoting weight loss; however, the efficacy of the blend has not been established. This randomized, placebo‐controlled, double‐blind, parallel group study conducted over 14 weeks (including a 2‐week run‐in phase) aimed to investigate the efficacy and safety of IQP‐GC‐101 in reducing body weight and body fat mass in overweight Caucasian adults. Subjects took three IQP‐GC‐...
Source: Phytotherapy Research - May 2, 2014 Category: Biochemistry Authors: Pee‐Win Chong, Zhi‐Ming Beah, Barbara Grube, Linda Riede Tags: Research Article Source Type: research

Serotonin Toxicity Associated with Garcinia cambogia Over-the-counter Supplement.
PMID: 24699886 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - April 4, 2014 Category: Toxicology Authors: Lopez AM, Kornegay J, Hendrickson RG Tags: J Med Toxicol Source Type: research

Hydroxycitric acid does not promote inflammation or liver toxicity.
Abstract Garcinia cambogia extract (GC) with its active component consisting of hydroxycitric acid (HCA) is widely utilized for weight loss. Various HCA salts are available, including calcium, magnesium, potassium and mixtures of these. Experimentally, these salts exhibit different properties with some, but not all, improving glucose tolerance and blood pressure. Recently, obesity-prone C57BL/6J mice were fed a high-fat diet (HFD, 45 kcal% fat) with or without GC (1%, w/w) for 16 wk. The active arm reduced visceral fat, adipocyte size and serum glucose, yet purportedly also exhibited hepatic collagen accumulation,...
Source: World Journal of Gastroenterology : WJG - November 28, 2013 Category: Gastroenterology Authors: Clouatre DL, Preuss HG Tags: World J Gastroenterol Source Type: research