Evidence for Fat-Triggered Immune Dysfunction in the Liver to Contribute to the Symptoms of Type 2 Diabetes
In this research, scientists explore a link between the presence of excess fat and the dysfunctional blood sugar regulation that is characteristic of type 2 diabetes. The vast majority of type 2 diabetes patients suffer the condition because they are overweight, and could turn back its progression even in late stages through sustained low-calorie diets and losing that weight. Type 2 diabetes is a prevalent age-related disease because we live in an age of cheap calories and little exercise, older people have more time and opportunity to gain the necessary excess fat tissue to trigger the condition, and other mechanisms caus...
Source: Fight Aging! - April 24, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 3rd 2017
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - April 2, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Examination of Mitochondrial Dysfunction in Senescent Cells
Researchers here review what is known of mitochondrial dysfunction in cellular senescence. Senescent cells accumulate with age, and their growing presence is one of the contributing causes of degenerative aging. Some fraction of the damaging behavior of these cells, particularly their ability to generate chronic inflammation, may be driven by failing mitochondria, but there is the question of the ordering of cause and consequence here: does the state of cellular senescence tend to produce cells populated by damaged mitochondria, or is the sort of mitochondrial DNA damage outlined in the SENS view of aging causing cellular ...
Source: Fight Aging! - March 28, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Weight loss that works: A true story
Many people struggle with being overweight, or even obese. It’s a common topic at office visits. As a doctor, I know that excess weight is associated with potentially serious health conditions — high blood pressure, high blood sugar, high cholesterol — not to mention sleep apnea, fatty liver disease, and back and knee problems, among other things. Patients may also worry about their appearance.
Whether a patient is at risk for medical problems due to being overweight, or if it’s a personal health goal, then it’s my job to provide counseling.
In my experience, most patients consider weight loss drugs or surger...
Source: Harvard Health Blog - March 1, 2017 Category: Consumer Health News Authors: Monique Tello, MD, MPH Tags: Diet and Weight Loss Exercise and Fitness Health Healthy Eating Source Type: blogs
MKSAP: 55-year-old man with gout
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 55-year-old man is evaluated during a follow-up visit for gout. Two years ago, he had been treated with allopurinol and developed a hypersensitivity reaction. Over the past several months, he has had recurrent attacks of acute, episodic swelling of the first metatarsophalangeal joints with increasing involvement of other joints, including the ankles and knees. Laboratory studies showed significant hyperuricemia. History is also significant for Crohn disease, hypertension, chronic kidney disease (estimated glom...
Source: Kevin, M.D. - Medical Weblog - February 25, 2017 Category: Journals (General) Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Rheumatology Source Type: blogs
Investigating Mechanisms of Age-Related Increase in Fibrosis
Fibrosis is a form of scarring, important in many medical conditions, notably those of the liver, and a process that increases in many internal organ tissues with advancing age. Inappropriate levels of cellular construction of fibrotic structures disrupts the proper function of tissues, leading to dysfunction and disease. Researchers here look into the underlying mechanisms driving that age-related increase in fibrosis, and suggest that the problem lies in a reduced ability to clear out fibrosis rather than an increased tendency to generate these structures in response to damage. The researchers point to the presence of cr...
Source: Fight Aging! - January 3, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
MKSAP: 68-year-old woman with progressive abdominal distention
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 68-year-old woman is evaluated for a 3-month history of gradually progressive abdominal distention. Her medical history is notable for a 20-year history of obesity, type 2 diabetes mellitus, hyperlipidemia, and hypertension. She also has had a 10-year history of elevation of serum aminotransferase levels, which was attributed to nonalcoholic fatty liver disease. She does not consume alcohol. Her medications are metformin, lisinopril, low-dose aspirin, and simvastatin.
On physical examination, vital signs are n...
Source: Kevin, M.D. - Medical Weblog - December 24, 2016 Category: Journals (General) Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions GI Source Type: blogs
Fat Blasters: Ketosis ’ best friend
After elimination of virtually all dietary carbohydrates/sugars, the key to achieving physiologic ketosis is to maintain high fat intake. Not increased protein intake that can, in fact, “turn off” ketosis, since liberal protein intake modestly increases blood insulin and sugar levels, thereby undoing the process that generates ketosis. The key is to increase fat intake and thereby feel satiated and turn off all desire for carbs while not provoking insulin release. If accelerated weight loss or breaking a weight loss plateau is among your goals, increased fat intake—counterintuitively—encourages mobi...
Source: Wheat Belly Blog - December 5, 2016 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle carbs fat blasters gluten grains ketosis low-carb Source Type: blogs
MKSAP: 68-year-old woman with gradually progressive abdominal distention
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 68-year-old woman is evaluated for a 3-month history of gradually progressive abdominal distention. Her medical history is notable for a 20-year history of obesity, type 2 diabetes mellitus, hyperlipidemia, and hypertension. She also has had a 10-year history of elevation of serum aminotransferase levels, which was attributed to nonalcoholic fatty liver disease. She does not consume alcohol. Her medications are metformin, lisinopril, low-dose aspirin, and simvastatin.
On physical examination, vital signs are n...
Source: Kevin, M.D. - Medical Weblog - September 24, 2016 Category: Journals (General) Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions GI Source Type: blogs
Fight Aging! Newsletter, May 16th 2016
In this study the authors demonstrate that, as in many other cases, the methodology of delivery matters just as much as the details of the cells used:
Retinal and macular degenerative diseases affect millions of people worldwide. Similar to other neurodegenerative diseases, there are no effective treatments that can stop retinal degeneration or restore degenerative retina. Recent advances in stem cell technology led to development of novel cell-based therapies, some are already in phase I/II clinical trials. Studies from our group and others suggest that human bone marrow-derived mesenchymal stem cells (hBM-MSC) m...
Source: Fight Aging! - May 15, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
GADD45β in the Mechanisms of Fasting and Calorie Restriction
Lower calorie intake, while still obtaining required levels of micronutrients, has long been demonstrated to improve near all measures of health, leads to better quality of life, and modestly slows aging. A higher calorie intake leads to visceral fat deposition, metabolic syndrome, type 2 diabetes, fatty liver disease, and a shorter, less healthy life. Separately, fasting appears to have similar influences on health and aging to those produced by a lower calorie intake, but to some degree independently of overall calorie level - though it is worth noting that the body of research here is much smaller than that for calorie ...
Source: Fight Aging! - May 10, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Stephen’s return from the medical quagmire
Stephen shared his 60-day Wheat Belly experience:
“Started Wheat Belly 60 days ago after a major health crisis. I found out I had type 2 diabetes 2 and very bad cholesterol. My numbers 60 days ago were: cholesterol 189, triglycerides 475, LDL could not be measured as it was so bad, HDL was 32. Two weeks ago: 20 pound weight loss, wearing a 15.5-inch neck size shirt compared to an 18. Triglycerides 79, LDL 25, HDL 40, cholesterol 81.
“I was first told on January 24, 2016 that my glucose level was 157. Forty five days later, my average glucose was 107 when measured by my diabetes counselor by downloading the data...
Source: Wheat Belly Blog - April 7, 2016 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Success Stories cholesterol diabetes gluten grains HDL statins triglycerides Weight Loss Source Type: blogs
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Michelle shared her 30-day progress pictures after starting the Wheat Belly lifestyle.
“This is Day 1 and Day 30 eliminating the wheat. Same time of day, fresh out of the shower, exact same lighting, and I promise, that is not a tan, it’s the middle of winter in Philly. I’m obese and was diagnosed with NAFLD, but thanks to Wheat Belly, I’m well on my way to finally getting healthy.
“I lost 15 lbs in the first 30 days and am off all of medication for GERD. I truly believe that it was wheat making me sick.”
Michelle’s facial changes are subtle, but there is most definitely a differe...
Source: Wheat Belly Blog - March 27, 2016 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Success Stories acid reflux esophagitis facial change fatty liver gerd gluten grains Inflammation NAFLD Source Type: blogs
Looks what 30 days of Wheat Belly did for Michelle
Michelle shared her 30-day progress pictures after starting the Wheat Belly lifestyle.
“This is Day 1 and Day 30 eliminating the wheat. Same time of day, fresh out of the shower, exact same lighting, and I promise, that is not a tan, it’s the middle of winter in Philly. I’m obese and was diagnosed with NAFLD, but thanks to Wheat Belly, I’m well on my way to finally getting healthy.
“I lost 15 lbs in the first 30 days and am off all of medication for GERD. I truly believe that it was wheat making me sick.”
Michelle’s facial changes are subtle, but there is most definitely a differe...
Source: Wheat Belly Blog - March 27, 2016 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Success Stories acid reflux esophagitis facial change fatty liver gerd gluten grains Inflammation NAFLD Source Type: blogs
Don’t exercise to lose weight
There are plenty of good reasons to exercise . . . but losing weight is not one of them.
Yes, there are people, genetically-determined or armed with extraordinary determination, who can lose weight with a strenuous exercise program. But the majority lose a modest quantity and that’s the end of it. They even continue to torture themselves for years, telling themselves that they are burning calories, burning off fat, and if they would only exercise longer and harder they would lose weight–but don’t.
Is it worth exercising if it does not result in substantial control over weight? Yes, indeed it is. Among the...
Source: Wheat Belly Blog - March 16, 2016 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle blood sugar exercise glucose gluten grains insulin Weight Loss Source Type: blogs
