Prognostic value of HE4 in advanced-stage, high-grade serous ovarian cancer: Analysis of HE4 kinetics during NACT, predicting surgical outcome and recurrence in comparison to CA125
CONCLUSION: Monitoring HE4 or CA-125 levels has low prognostic value in patients with advanced-stage, high-grade serous ovarian cancer who are treated with NACT followed by IDS. However, the preoperative level of the HE4 biomarker may be useful in identifying patients at higher risk for suboptimal cytoreductive surgery or who may require more extensive surgery. Further prospective studies are warranted to explore the prognostic utility of eventual combinations of clinical, radiological, and biological parameters, notably by using artificial intelligence-based models.PMID:38176127 | DOI:10.1016/j.ygyno.2023.12.021 (Source: ...
Source: Gynecologic Oncology - January 4, 2024 Category: Cancer & Oncology Authors: Amal AlSomairi Samah Himayda Ahmed Altelmesani Yong Jae Lee Jung-Yun Lee Source Type: research
Early Ovarian Cancer Detection in the Age of Fallopian Tube Precursors: A Systematic Review
CONCLUSION: These findings suggest that although many types of biomarkers are being tested in ovarian cancer, most have similar or worse detection rates compared with CA 125 and have the same limitations of poor detection rates in early-stage disease. However, 27.5% of articles (36/131) reported biomarkers with better sensitivity and an AUC greater than 0.9 compared with CA 125 alone and deserve further exploration.PMID:38176019 | DOI:10.1097/AOG.0000000000005496 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - January 4, 2024 Category: OBGYN Authors: Ashley Greenwood Elizabeth R Woodruff Cam Nguyen Christi Piper Aaron Clauset Lindsay W Brubaker Kian Behbakht Benjamin G Bitler Source Type: research
Prognostic value of HE4 in advanced-stage, high-grade serous ovarian cancer: Analysis of HE4 kinetics during NACT, predicting surgical outcome and recurrence in comparison to CA125
CONCLUSION: Monitoring HE4 or CA-125 levels has low prognostic value in patients with advanced-stage, high-grade serous ovarian cancer who are treated with NACT followed by IDS. However, the preoperative level of the HE4 biomarker may be useful in identifying patients at higher risk for suboptimal cytoreductive surgery or who may require more extensive surgery. Further prospective studies are warranted to explore the prognostic utility of eventual combinations of clinical, radiological, and biological parameters, notably by using artificial intelligence-based models.PMID:38176127 | DOI:10.1016/j.ygyno.2023.12.021 (Source: ...
Source: Gynecologic Oncology - January 4, 2024 Category: Cancer & Oncology Authors: Amal AlSomairi Samah Himayda Ahmed Altelmesani Yong Jae Lee Jung-Yun Lee Source Type: research
Early Ovarian Cancer Detection in the Age of Fallopian Tube Precursors: A Systematic Review
CONCLUSION: These findings suggest that although many types of biomarkers are being tested in ovarian cancer, most have similar or worse detection rates compared with CA 125 and have the same limitations of poor detection rates in early-stage disease. However, 27.5% of articles (36/131) reported biomarkers with better sensitivity and an AUC greater than 0.9 compared with CA 125 alone and deserve further exploration.PMID:38176019 | DOI:10.1097/AOG.0000000000005496 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - January 4, 2024 Category: OBGYN Authors: Ashley Greenwood Elizabeth R Woodruff Cam Nguyen Christi Piper Aaron Clauset Lindsay W Brubaker Kian Behbakht Benjamin G Bitler Source Type: research
Early Ovarian Cancer Detection in the Age of Fallopian Tube Precursors: A Systematic Review
CONCLUSION: These findings suggest that although many types of biomarkers are being tested in ovarian cancer, most have similar or worse detection rates compared with CA 125 and have the same limitations of poor detection rates in early-stage disease. However, 27.5% of articles (36/131) reported biomarkers with better sensitivity and an AUC greater than 0.9 compared with CA 125 alone and deserve further exploration.PMID:38176019 | DOI:10.1097/AOG.0000000000005496 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - January 4, 2024 Category: OBGYN Authors: Ashley Greenwood Elizabeth R Woodruff Cam Nguyen Christi Piper Aaron Clauset Lindsay W Brubaker Kian Behbakht Benjamin G Bitler Source Type: research
Early Ovarian Cancer Detection in the Age of Fallopian Tube Precursors: A Systematic Review
CONCLUSION: These findings suggest that although many types of biomarkers are being tested in ovarian cancer, most have similar or worse detection rates compared with CA 125 and have the same limitations of poor detection rates in early-stage disease. However, 27.5% of articles (36/131) reported biomarkers with better sensitivity and an AUC greater than 0.9 compared with CA 125 alone and deserve further exploration.PMID:38176019 | DOI:10.1097/AOG.0000000000005496 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - January 4, 2024 Category: OBGYN Authors: Ashley Greenwood Elizabeth R Woodruff Cam Nguyen Christi Piper Aaron Clauset Lindsay W Brubaker Kian Behbakht Benjamin G Bitler Source Type: research
Beyond Sterilization: A Comprehensive Review on the Safety and Efficacy of Opportunistic Salpingectomy as a Preventative Strategy for Ovarian Cancer
This article aims to compile and review the studies evaluating the effect of opportunistic salpingectomy on surgical-related complications, ovarian reserve, cost, and OC incidence when performed along with hysterectomy or instead of tubal ligation in the general population.PMID:38132373 | DOI:10.3390/curroncol30120739 (Source: Current Oncology)
Source: Current Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Tahereh Zadabedini Masouleh Holly Etchegary Kathleen Hodgkinson Brenda J Wilson Lesa Dawson Source Type: research
Beyond Sterilization: A Comprehensive Review on the Safety and Efficacy of Opportunistic Salpingectomy as a Preventative Strategy for Ovarian Cancer
This article aims to compile and review the studies evaluating the effect of opportunistic salpingectomy on surgical-related complications, ovarian reserve, cost, and OC incidence when performed along with hysterectomy or instead of tubal ligation in the general population.PMID:38132373 | PMC:PMC10742942 | DOI:10.3390/curroncol30120739 (Source: Current Oncology)
Source: Current Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Tahereh Zadabedini Masouleh Holly Etchegary Kathleen Hodgkinson Brenda J Wilson Lesa Dawson Source Type: research
