The CMS Reveals First 10 Drugs for Medicare Drug Negotiation
The long-awaited list of the first 10 Part D drugs to be included in the new Medicare Price Negotiation process includes the commonly prescribed rheumatology drugs Enbrel and Stelara. Initial negotiations with the drug manufacturers will begin this fall. (Source: The Rheumatologist)
Source: The Rheumatologist - October 9, 2023 Category: Rheumatology Authors: From the College Tags: Practice Support drug pricing Medicare Price Negotiation Source Type: research
Short-, Mid-, and Long-Term Efficacy of Deucravacitinib Versus Biologics and Nonbiologics for Plaque Psoriasis: A Network Meta-Analysis
ConclusionsPatients receiving deucravacitinib were more likely to achieve PASI 75 response versus apremilast and methotrexate across all time points. The long-term PASI 75 response rate for deucravacitinib was similar to those of adalimumab and ustekinumab. The approval of deucravacitinib offers patients the choice of an oral therapy with long-term efficacy similar to that of some biologics. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - October 6, 2023 Category: Dermatology Source Type: research
Etanercept
(Source: Reactions Weekly)
Source: Reactions Weekly - October 1, 2023 Category: Drugs & Pharmacology Source Type: research
Multifocal leukoencephalopathy in a patient medicated with etanercept and methotrexate for rheumatoid arthritis
Z Rheumatol. 2023 Sep 27. doi: 10.1007/s00393-023-01430-6. Online ahead of print.ABSTRACTMethotrexate (MTX) and etanercept are commonly used in the treatment of rheumatoid arthritis (RA). Several important adverse events, including central nervous system lesions, have been reported during RA treatment. Among them, MTX-induced leukoencephalopathy is a recognized complication that is often observed following intrathecal or intravenous MTX administration. Herein, we report a case of a RA patient who was diagnosed with multifocal leukoencephalopathy during etanercept and MTX therapy. A 77-year-old Chinese woman with a 3-year h...
Source: Zeitschrift fur Rheumatologie - September 27, 2023 Category: Rheumatology Authors: Tieer Yu Chunying Yang Source Type: research
Multifocal leukoencephalopathy in a patient medicated with etanercept and methotrexate for rheumatoid arthritis
Z Rheumatol. 2023 Sep 27. doi: 10.1007/s00393-023-01430-6. Online ahead of print.ABSTRACTMethotrexate (MTX) and etanercept are commonly used in the treatment of rheumatoid arthritis (RA). Several important adverse events, including central nervous system lesions, have been reported during RA treatment. Among them, MTX-induced leukoencephalopathy is a recognized complication that is often observed following intrathecal or intravenous MTX administration. Herein, we report a case of a RA patient who was diagnosed with multifocal leukoencephalopathy during etanercept and MTX therapy. A 77-year-old Chinese woman with a 3-year h...
Source: Zeitschrift fur Rheumatologie - September 27, 2023 Category: Rheumatology Authors: Tieer Yu Chunying Yang Source Type: research
Multifocal leukoencephalopathy in a patient medicated with etanercept and methotrexate for rheumatoid arthritis
Z Rheumatol. 2023 Sep 27. doi: 10.1007/s00393-023-01430-6. Online ahead of print.ABSTRACTMethotrexate (MTX) and etanercept are commonly used in the treatment of rheumatoid arthritis (RA). Several important adverse events, including central nervous system lesions, have been reported during RA treatment. Among them, MTX-induced leukoencephalopathy is a recognized complication that is often observed following intrathecal or intravenous MTX administration. Herein, we report a case of a RA patient who was diagnosed with multifocal leukoencephalopathy during etanercept and MTX therapy. A 77-year-old Chinese woman with a 3-year h...
Source: Zeitschrift fur Rheumatologie - September 27, 2023 Category: Rheumatology Authors: Tieer Yu Chunying Yang Source Type: research
Autocrine positive feedback of tumor necrosis factor from activated microglia proposed to be of widespread relevance in chronic neurological disease
AbstractOver a decade's experience of post-stroke rehabilitation by administering the specific anti-TNF biological, etanercept, by the novel perispinal route, is consistent with a wide range of chronically diminished neurological function having been caused by persistent excessive cerebral levels of TNF. We propose that this TNF persistence, and cerebral disease chronicity, largely arises from a positive autocrine feedback loop of this cytokine, allowing the persistence of microglial activation caused by the excess TNF that these cells produce. It appears that many of these observations have never been exploited to constru...
Source: Pharmacology Research and Perspectives - September 27, 2023 Category: Drugs & Pharmacology Authors: Ian A. Clark,
Bryce Vissel Tags: REVIEW Source Type: research
Cost-Effectiveness of Secukinumab Versus Other Biologics in the Treatment of Moderate-to-Severe Plaque Psoriasis: The Chinese Healthcare System Perspective
ConclusionSecukinumab is the most cost-effective treatment option for patients with moderate-to-severe psoriasis compared with other commonly used biologics from the Chinese healthcare system perspective. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - September 23, 2023 Category: Dermatology Source Type: research
Correction: Etanercept is Effective and Halts Radiographic Progression in Rheumatoid Arthritis and Psoriatic Arthritis: Final Results from a German Non-interventional Study (PRERA)
(Source: Rheumatology and Therapy)
Source: Rheumatology and Therapy - September 20, 2023 Category: Rheumatology Source Type: research
Correction to: The effective threshold dose of etanercept in patients with methotrexate-resistant rheumatoid arthritis
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - September 14, 2023 Category: Rheumatology Source Type: research
