Astragalus (Astragalus mongholicus) Improves Ventricular Remodeling via ESR1 Downregulation RhoA/ROCK Pathway
This study aims to investigate the effect of Astragalus on ventricular remodeling in ovariectomized spontaneous hypertensive rats (OVX-SHR).Female SHR/NCrl rats were subjected to bilateral ovariectomy to establish the OVX-SHR model and treated with Astragalus extract by gavage. The hemodynamics and cardiac function parameters were measured. HE and Masson staining were used to detect the pathological structure of myocardial remodeling and observe the hyperplasia of myocardial collagen fibers. The immunohistochemistry tested the level of α-SMA. The expression levels of inflammatory cytokines, IκB, p65, Cleaved-Caspase3, Rh...
Source: International Heart Journal - November 15, 2023 Category: Cardiology Authors: Hualei Dai Siming Tao Yingxia Guan Yijian Zhang Zhigang Yang Ji Jia Xinjin Zhang Guimin Zhang Source Type: research
Longitudinal Changes in Natriuretic Peptides and Reverse Cardiac Remodeling in Patients with Heart Failure Treated with Sacubitril/Valsartan Across the Left Ventricular Ejection Traction Spectrum
Int Heart J. 2023 Nov 14. doi: 10.1536/ihj.23-407. Online ahead of print.ABSTRACTSacubitril/valsartan improves outcomes in patients with heart failure (HF) with reduced ejection fraction. However, the relationship between longitudinal changes in natriuretic peptides and echocardiographic parameters in patients with HF treated with sacubitril/valsartan across the left ventricular ejection fraction (LVEF) range is not fully understood.In patients with HF treated with sacubitril/valsartan, comprehensive data on natriuretic peptides, including atrial natriuretic peptide (ANP), N-terminal pro-brain-type natriuretic peptide (NT-...
Source: International Heart Journal - November 15, 2023 Category: Cardiology Authors: Masayoshi Yamamoto Tomoko Ishizu Kimi Sato Kentaro Minami Taikan Terauchi Tomofumi Nakatsukasa Naoto Kawamatsu Tomoko Machino-Ohtsuka Masaki Ieda Source Type: research
Astragalus (Astragalus mongholicus) Improves Ventricular Remodeling via ESR1 Downregulation RhoA/ROCK Pathway
This study aims to investigate the effect of Astragalus on ventricular remodeling in ovariectomized spontaneous hypertensive rats (OVX-SHR).Female SHR/NCrl rats were subjected to bilateral ovariectomy to establish the OVX-SHR model and treated with Astragalus extract by gavage. The hemodynamics and cardiac function parameters were measured. HE and Masson staining were used to detect the pathological structure of myocardial remodeling and observe the hyperplasia of myocardial collagen fibers. The immunohistochemistry tested the level of α-SMA. The expression levels of inflammatory cytokines, IκB, p65, Cleaved-Caspase3, Rh...
Source: International Heart Journal - November 15, 2023 Category: Cardiology Authors: Hualei Dai Siming Tao Yingxia Guan Yijian Zhang Zhigang Yang Ji Jia Xinjin Zhang Guimin Zhang Source Type: research
Longitudinal Changes in Natriuretic Peptides and Reverse Cardiac Remodeling in Patients with Heart Failure Treated with Sacubitril/Valsartan Across the Left Ventricular Ejection Traction Spectrum
Int Heart J. 2023 Nov 14. doi: 10.1536/ihj.23-407. Online ahead of print.ABSTRACTSacubitril/valsartan improves outcomes in patients with heart failure (HF) with reduced ejection fraction. However, the relationship between longitudinal changes in natriuretic peptides and echocardiographic parameters in patients with HF treated with sacubitril/valsartan across the left ventricular ejection fraction (LVEF) range is not fully understood.In patients with HF treated with sacubitril/valsartan, comprehensive data on natriuretic peptides, including atrial natriuretic peptide (ANP), N-terminal pro-brain-type natriuretic peptide (NT-...
Source: International Heart Journal - November 15, 2023 Category: Cardiology Authors: Masayoshi Yamamoto Tomoko Ishizu Kimi Sato Kentaro Minami Taikan Terauchi Tomofumi Nakatsukasa Naoto Kawamatsu Tomoko Machino-Ohtsuka Masaki Ieda Source Type: research
Astragalus (Astragalus mongholicus) Improves Ventricular Remodeling via ESR1 Downregulation RhoA/ROCK Pathway
This study aims to investigate the effect of Astragalus on ventricular remodeling in ovariectomized spontaneous hypertensive rats (OVX-SHR).Female SHR/NCrl rats were subjected to bilateral ovariectomy to establish the OVX-SHR model and treated with Astragalus extract by gavage. The hemodynamics and cardiac function parameters were measured. HE and Masson staining were used to detect the pathological structure of myocardial remodeling and observe the hyperplasia of myocardial collagen fibers. The immunohistochemistry tested the level of α-SMA. The expression levels of inflammatory cytokines, IκB, p65, Cleaved-Caspase3, Rh...
Source: International Heart Journal - November 15, 2023 Category: Cardiology Authors: Hualei Dai Siming Tao Yingxia Guan Yijian Zhang Zhigang Yang Ji Jia Xinjin Zhang Guimin Zhang Source Type: research
Longitudinal Changes in Natriuretic Peptides and Reverse Cardiac Remodeling in Patients with Heart Failure Treated with Sacubitril/Valsartan Across the Left Ventricular Ejection Traction Spectrum
Int Heart J. 2023 Nov 14. doi: 10.1536/ihj.23-407. Online ahead of print.ABSTRACTSacubitril/valsartan improves outcomes in patients with heart failure (HF) with reduced ejection fraction. However, the relationship between longitudinal changes in natriuretic peptides and echocardiographic parameters in patients with HF treated with sacubitril/valsartan across the left ventricular ejection fraction (LVEF) range is not fully understood.In patients with HF treated with sacubitril/valsartan, comprehensive data on natriuretic peptides, including atrial natriuretic peptide (ANP), N-terminal pro-brain-type natriuretic peptide (NT-...
Source: International Heart Journal - November 15, 2023 Category: Cardiology Authors: Masayoshi Yamamoto Tomoko Ishizu Kimi Sato Kentaro Minami Taikan Terauchi Tomofumi Nakatsukasa Naoto Kawamatsu Tomoko Machino-Ohtsuka Masaki Ieda Source Type: research
Astragalus (Astragalus mongholicus) Improves Ventricular Remodeling via ESR1 Downregulation RhoA/ROCK Pathway
This study aims to investigate the effect of Astragalus on ventricular remodeling in ovariectomized spontaneous hypertensive rats (OVX-SHR).Female SHR/NCrl rats were subjected to bilateral ovariectomy to establish the OVX-SHR model and treated with Astragalus extract by gavage. The hemodynamics and cardiac function parameters were measured. HE and Masson staining were used to detect the pathological structure of myocardial remodeling and observe the hyperplasia of myocardial collagen fibers. The immunohistochemistry tested the level of α-SMA. The expression levels of inflammatory cytokines, IκB, p65, Cleaved-Caspase3, Rh...
Source: International Heart Journal - November 15, 2023 Category: Cardiology Authors: Hualei Dai Siming Tao Yingxia Guan Yijian Zhang Zhigang Yang Ji Jia Xinjin Zhang Guimin Zhang Source Type: research
Longitudinal Changes in Natriuretic Peptides and Reverse Cardiac Remodeling in Patients with Heart Failure Treated with Sacubitril/Valsartan Across the Left Ventricular Ejection Traction Spectrum
Int Heart J. 2023 Nov 14. doi: 10.1536/ihj.23-407. Online ahead of print.ABSTRACTSacubitril/valsartan improves outcomes in patients with heart failure (HF) with reduced ejection fraction. However, the relationship between longitudinal changes in natriuretic peptides and echocardiographic parameters in patients with HF treated with sacubitril/valsartan across the left ventricular ejection fraction (LVEF) range is not fully understood.In patients with HF treated with sacubitril/valsartan, comprehensive data on natriuretic peptides, including atrial natriuretic peptide (ANP), N-terminal pro-brain-type natriuretic peptide (NT-...
Source: International Heart Journal - November 15, 2023 Category: Cardiology Authors: Masayoshi Yamamoto Tomoko Ishizu Kimi Sato Kentaro Minami Taikan Terauchi Tomofumi Nakatsukasa Naoto Kawamatsu Tomoko Machino-Ohtsuka Masaki Ieda Source Type: research
Astragalus (Astragalus mongholicus) Improves Ventricular Remodeling via ESR1 Downregulation RhoA/ROCK Pathway
This study aims to investigate the effect of Astragalus on ventricular remodeling in ovariectomized spontaneous hypertensive rats (OVX-SHR).Female SHR/NCrl rats were subjected to bilateral ovariectomy to establish the OVX-SHR model and treated with Astragalus extract by gavage. The hemodynamics and cardiac function parameters were measured. HE and Masson staining were used to detect the pathological structure of myocardial remodeling and observe the hyperplasia of myocardial collagen fibers. The immunohistochemistry tested the level of α-SMA. The expression levels of inflammatory cytokines, IκB, p65, Cleaved-Caspase3, Rh...
Source: International Heart Journal - November 15, 2023 Category: Cardiology Authors: Hualei Dai Siming Tao Yingxia Guan Yijian Zhang Zhigang Yang Ji Jia Xinjin Zhang Guimin Zhang Source Type: research
Longitudinal Changes in Natriuretic Peptides and Reverse Cardiac Remodeling in Patients with Heart Failure Treated with Sacubitril/Valsartan Across the Left Ventricular Ejection Traction Spectrum
Int Heart J. 2023 Nov 14. doi: 10.1536/ihj.23-407. Online ahead of print.ABSTRACTSacubitril/valsartan improves outcomes in patients with heart failure (HF) with reduced ejection fraction. However, the relationship between longitudinal changes in natriuretic peptides and echocardiographic parameters in patients with HF treated with sacubitril/valsartan across the left ventricular ejection fraction (LVEF) range is not fully understood.In patients with HF treated with sacubitril/valsartan, comprehensive data on natriuretic peptides, including atrial natriuretic peptide (ANP), N-terminal pro-brain-type natriuretic peptide (NT-...
Source: International Heart Journal - November 15, 2023 Category: Cardiology Authors: Masayoshi Yamamoto Tomoko Ishizu Kimi Sato Kentaro Minami Taikan Terauchi Tomofumi Nakatsukasa Naoto Kawamatsu Tomoko Machino-Ohtsuka Masaki Ieda Source Type: research
Astragalus (Astragalus mongholicus) Improves Ventricular Remodeling via ESR1 Downregulation RhoA/ROCK Pathway
This study aims to investigate the effect of Astragalus on ventricular remodeling in ovariectomized spontaneous hypertensive rats (OVX-SHR).Female SHR/NCrl rats were subjected to bilateral ovariectomy to establish the OVX-SHR model and treated with Astragalus extract by gavage. The hemodynamics and cardiac function parameters were measured. HE and Masson staining were used to detect the pathological structure of myocardial remodeling and observe the hyperplasia of myocardial collagen fibers. The immunohistochemistry tested the level of α-SMA. The expression levels of inflammatory cytokines, IκB, p65, Cleaved-Caspase3, Rh...
Source: International Heart Journal - November 15, 2023 Category: Cardiology Authors: Hualei Dai Siming Tao Yingxia Guan Yijian Zhang Zhigang Yang Ji Jia Xinjin Zhang Guimin Zhang Source Type: research
Longitudinal Changes in Natriuretic Peptides and Reverse Cardiac Remodeling in Patients with Heart Failure Treated with Sacubitril/Valsartan Across the Left Ventricular Ejection Traction Spectrum
Int Heart J. 2023 Nov 30;64(6):1071-1078. doi: 10.1536/ihj.23-407. Epub 2023 Nov 14.ABSTRACTSacubitril/valsartan improves outcomes in patients with heart failure (HF) with reduced ejection fraction. However, the relationship between longitudinal changes in natriuretic peptides and echocardiographic parameters in patients with HF treated with sacubitril/valsartan across the left ventricular ejection fraction (LVEF) range is not fully understood.In patients with HF treated with sacubitril/valsartan, comprehensive data on natriuretic peptides, including atrial natriuretic peptide (ANP), N-terminal pro-brain-type natriuretic p...
Source: International Heart Journal - November 15, 2023 Category: Cardiology Authors: Masayoshi Yamamoto Tomoko Ishizu Kimi Sato Kentaro Minami Taikan Terauchi Tomofumi Nakatsukasa Naoto Kawamatsu Tomoko Machino-Ohtsuka Masaki Ieda Source Type: research
Reverse Remodeling in Heart Failure With Reduced Ejection Fraction Induced by Sacubitril-Valsartan: 3-Dimensional Echocardiography May Be a Useful Tool for the Future
The structural changes that occur in the left ventricle in heart failure (HF) with reduced ejection fraction (HFrEF) because of the activation of neurohormonal changes are known as remodeling. Initially, remodeling is a compensatory mechanism to maintain cardiac output in the face of a decrease in stroke volume, before eventually becoming pathologic. Remodeling over time leads to increased left ventricular (LV) volume and alteration in left ventricular (LV) geometry. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - November 14, 2023 Category: Cardiology Authors: Hanna N. Ahmed Tags: Editorial Source Type: research
Correction to “Exploration of chiral drugs as references for chiral discrimination of valsartan and voriconazole by tandem mass spectrometry”
(Source: Journal of Mass Spectrometry)
Source: Journal of Mass Spectrometry - November 10, 2023 Category: Chemistry Tags: CORRECTION Source Type: research
Kidneys in heart failure: Impact of flozins and beyond
Kardiol Pol. 2023 Nov 8. doi: 10.33963/v.kp.97844. Online ahead of print.ABSTRACTChronic kidney disease (CKD) and heart failure (HF) represent two modern epidemies and are closely related. According to the concept of cardio-renal and reno-cardiac syndromes most of patients with CKD are affected by cardiovascular disease (CVD) and CVD (including HF) is one of the factors not only promoting progression of established CKD, but also triggering its onset and development. Treatment of CVD and HF in CKD patients remains to be challenging since CKD patients are characterized by extremely diverse and strongly expressed risk profile...
Source: Polish Heart Journal - November 8, 2023 Category: Cardiology Authors: Tomasz Stomp ór Agata Winiarska Source Type: research
