Kidneys in heart failure: Impact of flozins and beyond
Kardiol Pol. 2023 Nov 8. doi: 10.33963/v.kp.97844. Online ahead of print.ABSTRACTChronic kidney disease (CKD) and heart failure (HF) represent two modern epidemies and are closely related. According to the concept of cardio-renal and reno-cardiac syndromes most of patients with CKD are affected by cardiovascular disease (CVD) and CVD (including HF) is one of the factors not only promoting progression of established CKD, but also triggering its onset and development. Treatment of CVD and HF in CKD patients remains to be challenging since CKD patients are characterized by extremely diverse and strongly expressed risk profile...
Source: Kardiologia Polska - November 8, 2023 Category: Cardiology Authors: Tomasz Stomp ór Agata Winiarska Source Type: research
Sacubitril/valsartan attenuates myocardial inflammation, hypertrophy, and fibrosis in rats with heart failure with preserved ejection fraction
In this study, rats with HFpEF were induced by subjecting spontaneously hypertensive rats to a diet rich in fats, salts, and sugars, along with administering streptozotocin. Subsequently, they were administered Sac/val at a daily dosage of 18 mg/kg. Finally, Cardiac structure and function were assessed using echocardiography; Hematoxylin and eosin staining and Masson's trichrome staining were employed to evaluate the pathological changes; Quantitative real-time polymerase chain reaction and Western blot analysis were conducted to determine the expression of pertinent mRNA and proteins. Sac/val treatment attenuated left ven...
Source: European Journal of Pharmacology - November 8, 2023 Category: Drugs & Pharmacology Authors: Yu Jiao Shi Chen Guang Yang Wen Bo Qiao Yong Cheng Liu Si Yu Liu Guo Ju Dong Source Type: research
Kidneys in heart failure: Impact of flozins and beyond
Kardiol Pol. 2023 Nov 8. doi: 10.33963/v.kp.97844. Online ahead of print.ABSTRACTChronic kidney disease (CKD) and heart failure (HF) represent two modern epidemies and are closely related. According to the concept of cardio-renal and reno-cardiac syndromes most of patients with CKD are affected by cardiovascular disease (CVD) and CVD (including HF) is one of the factors not only promoting progression of established CKD, but also triggering its onset and development. Treatment of CVD and HF in CKD patients remains to be challenging since CKD patients are characterized by extremely diverse and strongly expressed risk profile...
Source: Polish Heart Journal - November 8, 2023 Category: Cardiology Authors: Tomasz Stomp ór Agata Winiarska Source Type: research
Kidneys in heart failure: Impact of flozins and beyond
Kardiol Pol. 2023 Nov 8. doi: 10.33963/v.kp.97844. Online ahead of print.ABSTRACTChronic kidney disease (CKD) and heart failure (HF) represent two modern epidemies and are closely related. According to the concept of cardio-renal and reno-cardiac syndromes most of patients with CKD are affected by cardiovascular disease (CVD) and CVD (including HF) is one of the factors not only promoting progression of established CKD, but also triggering its onset and development. Treatment of CVD and HF in CKD patients remains to be challenging since CKD patients are characterized by extremely diverse and strongly expressed risk profile...
Source: Kardiologia Polska - November 8, 2023 Category: Cardiology Authors: Tomasz Stomp ór Agata Winiarska Source Type: research
Sacubitril/valsartan attenuates myocardial inflammation, hypertrophy, and fibrosis in rats with heart failure with preserved ejection fraction
In this study, rats with HFpEF were induced by subjecting spontaneously hypertensive rats to a diet rich in fats, salts, and sugars, along with administering streptozotocin. Subsequently, they were administered Sac/val at a daily dosage of 18 mg/kg. Finally, Cardiac structure and function were assessed using echocardiography; Hematoxylin and eosin staining and Masson's trichrome staining were employed to evaluate the pathological changes; Quantitative real-time polymerase chain reaction and Western blot analysis were conducted to determine the expression of pertinent mRNA and proteins. Sac/val treatment attenuated left ven...
Source: European Journal of Pharmacology - November 8, 2023 Category: Drugs & Pharmacology Authors: Yu Jiao Shi Chen Guang Yang Wen Bo Qiao Yong Cheng Liu Si Yu Liu Guo Ju Dong Source Type: research
Kidneys in heart failure: Impact of flozins and beyond
Kardiol Pol. 2023 Nov 8. doi: 10.33963/v.kp.97844. Online ahead of print.ABSTRACTChronic kidney disease (CKD) and heart failure (HF) represent two modern epidemies and are closely related. According to the concept of cardio-renal and reno-cardiac syndromes most of patients with CKD are affected by cardiovascular disease (CVD) and CVD (including HF) is one of the factors not only promoting progression of established CKD, but also triggering its onset and development. Treatment of CVD and HF in CKD patients remains to be challenging since CKD patients are characterized by extremely diverse and strongly expressed risk profile...
Source: Polish Heart Journal - November 8, 2023 Category: Cardiology Authors: Tomasz Stomp ór Agata Winiarska Source Type: research
Kidneys in heart failure: Impact of flozins and beyond
Kardiol Pol. 2023 Nov 8. doi: 10.33963/v.kp.97844. Online ahead of print.ABSTRACTChronic kidney disease (CKD) and heart failure (HF) represent two modern epidemies and are closely related. According to the concept of cardio-renal and reno-cardiac syndromes most of patients with CKD are affected by cardiovascular disease (CVD) and CVD (including HF) is one of the factors not only promoting progression of established CKD, but also triggering its onset and development. Treatment of CVD and HF in CKD patients remains to be challenging since CKD patients are characterized by extremely diverse and strongly expressed risk profile...
Source: Kardiologia Polska - November 8, 2023 Category: Cardiology Authors: Tomasz Stomp ór Agata Winiarska Source Type: research
Kidneys in heart failure: Impact of flozins and beyond
Kardiol Pol. 2023 Nov 8. doi: 10.33963/v.kp.97844. Online ahead of print.ABSTRACTChronic kidney disease (CKD) and heart failure (HF) represent two modern epidemies and are closely related. According to the concept of cardio-renal and reno-cardiac syndromes most of patients with CKD are affected by cardiovascular disease (CVD) and CVD (including HF) is one of the factors not only promoting progression of established CKD, but also triggering its onset and development. Treatment of CVD and HF in CKD patients remains to be challenging since CKD patients are characterized by extremely diverse and strongly expressed risk profile...
Source: Polish Heart Journal - November 8, 2023 Category: Cardiology Authors: Tomasz Stomp ór Agata Winiarska Source Type: research
Kidneys in heart failure: Impact of flozins and beyond
Kardiol Pol. 2023 Nov 8. doi: 10.33963/v.kp.97844. Online ahead of print.ABSTRACTChronic kidney disease (CKD) and heart failure (HF) represent two modern epidemies and are closely related. According to the concept of cardio-renal and reno-cardiac syndromes most of patients with CKD are affected by cardiovascular disease (CVD) and CVD (including HF) is one of the factors not only promoting progression of established CKD, but also triggering its onset and development. Treatment of CVD and HF in CKD patients remains to be challenging since CKD patients are characterized by extremely diverse and strongly expressed risk profile...
Source: Kardiologia Polska - November 8, 2023 Category: Cardiology Authors: Tomasz Stomp ór Agata Winiarska Source Type: research
Kidneys in heart failure: Impact of flozins and beyond
Kardiol Pol. 2023 Nov 8. doi: 10.33963/v.kp.97844. Online ahead of print.ABSTRACTChronic kidney disease (CKD) and heart failure (HF) represent two modern epidemies and are closely related. According to the concept of cardio-renal and reno-cardiac syndromes most of patients with CKD are affected by cardiovascular disease (CVD) and CVD (including HF) is one of the factors not only promoting progression of established CKD, but also triggering its onset and development. Treatment of CVD and HF in CKD patients remains to be challenging since CKD patients are characterized by extremely diverse and strongly expressed risk profile...
Source: Polish Heart Journal - November 8, 2023 Category: Cardiology Authors: Tomasz Stomp ór Agata Winiarska Source Type: research
Kidneys in heart failure: Impact of flozins and beyond
Kardiol Pol. 2023 Nov 8. doi: 10.33963/v.kp.97844. Online ahead of print.ABSTRACTChronic kidney disease (CKD) and heart failure (HF) represent two modern epidemies and are closely related. According to the concept of cardio-renal and reno-cardiac syndromes most of patients with CKD are affected by cardiovascular disease (CVD) and CVD (including HF) is one of the factors not only promoting progression of established CKD, but also triggering its onset and development. Treatment of CVD and HF in CKD patients remains to be challenging since CKD patients are characterized by extremely diverse and strongly expressed risk profile...
Source: Kardiologia Polska - November 8, 2023 Category: Cardiology Authors: Tomasz Stomp ór Agata Winiarska Source Type: research
Kidneys in heart failure: Impact of flozins and beyond
Kardiol Pol. 2023 Nov 8. doi: 10.33963/v.kp.97844. Online ahead of print.ABSTRACTChronic kidney disease (CKD) and heart failure (HF) represent two modern epidemies and are closely related. According to the concept of cardio-renal and reno-cardiac syndromes most of patients with CKD are affected by cardiovascular disease (CVD) and CVD (including HF) is one of the factors not only promoting progression of established CKD, but also triggering its onset and development. Treatment of CVD and HF in CKD patients remains to be challenging since CKD patients are characterized by extremely diverse and strongly expressed risk profile...
Source: Polish Heart Journal - November 8, 2023 Category: Cardiology Authors: Tomasz Stomp ór Agata Winiarska Source Type: research
Kidneys in heart failure: Impact of flozins and beyond
Kardiol Pol. 2023 Nov 8. doi: 10.33963/v.kp.97844. Online ahead of print.ABSTRACTChronic kidney disease (CKD) and heart failure (HF) represent two modern epidemies and are closely related. According to the concept of cardio-renal and reno-cardiac syndromes most of patients with CKD are affected by cardiovascular disease (CVD) and CVD (including HF) is one of the factors not only promoting progression of established CKD, but also triggering its onset and development. Treatment of CVD and HF in CKD patients remains to be challenging since CKD patients are characterized by extremely diverse and strongly expressed risk profile...
Source: Kardiologia Polska - November 8, 2023 Category: Cardiology Authors: Tomasz Stomp ór Agata Winiarska Source Type: research
Kidneys in heart failure: Impact of flozins and beyond
Kardiol Pol. 2023 Nov 8. doi: 10.33963/v.kp.97844. Online ahead of print.ABSTRACTChronic kidney disease (CKD) and heart failure (HF) represent two modern epidemies and are closely related. According to the concept of cardio-renal and reno-cardiac syndromes most of patients with CKD are affected by cardiovascular disease (CVD) and CVD (including HF) is one of the factors not only promoting progression of established CKD, but also triggering its onset and development. Treatment of CVD and HF in CKD patients remains to be challenging since CKD patients are characterized by extremely diverse and strongly expressed risk profile...
Source: Polish Heart Journal - November 8, 2023 Category: Cardiology Authors: Tomasz Stomp ór Agata Winiarska Source Type: research
Kidneys in heart failure: Impact of flozins and beyond
Kardiol Pol. 2023 Nov 8. doi: 10.33963/v.kp.97844. Online ahead of print.ABSTRACTChronic kidney disease (CKD) and heart failure (HF) represent two modern epidemies and are closely related. According to the concept of cardio-renal and reno-cardiac syndromes most of patients with CKD are affected by cardiovascular disease (CVD) and CVD (including HF) is one of the factors not only promoting progression of established CKD, but also triggering its onset and development. Treatment of CVD and HF in CKD patients remains to be challenging since CKD patients are characterized by extremely diverse and strongly expressed risk profile...
Source: Kardiologia Polska - November 8, 2023 Category: Cardiology Authors: Tomasz Stomp ór Agata Winiarska Source Type: research
