Desmoplastic Small Round Cell Tumor (DSRCT) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The Small Round Cell Sarcomas Complexities and Desmoplastic Presentation
Background: Small round cell sarcomas (SRCSs) account for most solid malignancies in the pediatric age group and are a part of group of malignant tumors characterized by heterogenous clinical presentation and overlapping microscopic features of small, round, primitive cells. In addition to the recently established certain genetically defined subset of undifferentiated round cell sarcomas of soft tissue and bone, this group of sarcomas include desmoplastic small round cell tumor, poorly differentiated synovial sarcoma, alveolar rhabdomyosarcoma, mesenchymal chondrosarcoma, and small cell osteosarcoma. Although, those entiti...
Source: Acta Cytologica - April 13, 2022 Category: Cytology Source Type: research

GSE197254 RNA-seq data of JN and BER-DSRCT dox inducible shSIK1 cell lines
Contributors : Nathan Ungerleider ; Lawrence ShiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDepletion of SIK1 expression in DSRCT cell lines affected expressions of genes in cell cycle regulation pathways. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 11, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Desmoplastic Small Round Cell Tumors With EWS-WT1 Transcript Expression: Should We Consider Children and Adult Patients Differently?
Desmoplastic small round cell tumor (DSRCT) is an aggressive sarcoma occurring in the young, teenager, and adult populations. The aim of this study is to compare initial tumor presentation, therapeutic management and scalability between pediatric and adult DSRCT patients and investigate the possibility of specific therapeutic approaches. A multicenter retrospective study of 81 Franco-Belgian medical files with DSRCT harboring Ewing sarcoma-Wilm tumor transcript was made. Median age was 17 years (3 to 58) with 42 children (13.5 y [3;17]) and 39 adults (28 y [18;58]). No significant differences were found between the 2 g...
Source: Journal of Pediatric Hematology Oncology - March 29, 2022 Category: Hematology Tags: Online Articles: Original Articles Source Type: research

Next generation sequencing in a cohort of patients with rare sarcoma histotypes: A single institution experience
Pathol Res Pract. 2022 Feb 25;232:153820. doi: 10.1016/j.prp.2022.153820. Online ahead of print.ABSTRACTSarcomas are mesenchymal-derived cancers with overlapping clinical and pathologic features and a remarkable histological heterogeneity. While a precise diagnosis is often challenging to achieve, systemic treatment of sarcomas is still quite uniform. In this scenario, next generation sequencing (NGS) may be exploited to assist diagnosis and to identify specific targetable alterations. However, the precise role of genomic characterization in these diseases is still debated. In the present study, we analyzed 18 samples from...
Source: Pathology, Research and Practice - March 3, 2022 Category: Pathology Authors: Elena Tirr ò Federica Martorana Giovanni Micale Nicola Inzerilli Rosaria Carciotto Chiara Romano Claudio Longhitano Gianmarco Motta Katia Lanzafame Stefania Stella Michele Massimino Silvia Rita Vitale Lucia Salvatorelli Gaetano Magro Livia Manzella Paolo Source Type: research

Next generation sequencing in a cohort of patients with rare sarcoma histotypes: A single institution experience
Pathol Res Pract. 2022 Feb 25;232:153820. doi: 10.1016/j.prp.2022.153820. Online ahead of print.ABSTRACTSarcomas are mesenchymal-derived cancers with overlapping clinical and pathologic features and a remarkable histological heterogeneity. While a precise diagnosis is often challenging to achieve, systemic treatment of sarcomas is still quite uniform. In this scenario, next generation sequencing (NGS) may be exploited to assist diagnosis and to identify specific targetable alterations. However, the precise role of genomic characterization in these diseases is still debated. In the present study, we analyzed 18 samples from...
Source: Cell Research - March 3, 2022 Category: Cytology Authors: Elena Tirr ò Federica Martorana Giovanni Micale Nicola Inzerilli Rosaria Carciotto Chiara Romano Claudio Longhitano Gianmarco Motta Katia Lanzafame Stefania Stella Michele Massimino Silvia Rita Vitale Lucia Salvatorelli Gaetano Magro Livia Manzella Paolo Source Type: research

Desmoplastic Small Round Cell Tumor Is an Important Mimic of High-Grade Carcinoma in Colonic Biopsy Samples
Desmoplastic small round cell tumor (DSRCT) is a rare but aggressive malignancy that usually occurs within the intra-abdominal cavities of young adult males. Most DSRCTs can be reliably diagnosed based on the presence of characteristic morphology; coexpression of epithelial, myogenic, and neural markers; and detection of the reciprocal translocation t(11;22)(p13:21) associated with the EWS::WT1 fusion. However, occasional tumors lack classic features, affect older adults, or are located outside the abdominal cavity. Mucosal biopsy samples can pose challenges when both the stromal and epithelial components are not represent...
Source: Pathology Case Reviews - March 1, 2022 Category: Pathology Tags: Case Reviews Source Type: research

GSE178406 The Androgen Receptor: A Therapeutic Target In Desmoplastic Small Round Cell Sarcoma
Contributors : Salah-Eddine Lamhamedi-Cherradi ; Brian A Menegaz ; Joseph A LudwigSeries Type : Protein profiling by protein arrayOrganism : Homo sapiensDesmoplastic small round cell tumor (DSRCT) is an aggressive, usually incurable sarcoma subtype that predominantly occurs in post-pubertal young males. Recent evidence suggests that the androgen receptor (AR) can promote tumor progression in DSRCTs. However, the mechanism of AR-induced oncogenic stimulation remains undetermined. Herein, we demonstrate that AR-directed antisense oligonucleotides (AR-ASO) block 5-dihydrotestosterone (DHT)-induced DSRCT cell proliferation a...
Source: GEO: Gene Expression Omnibus - February 28, 2022 Category: Genetics & Stem Cells Tags: Protein profiling by protein array Homo sapiens Source Type: research