Intra ‐abdominal omental mass as a desmoplastic round cell tumor: A rare case report
We present a young adult with a periumbilical mass who was diagnosed as a desmoplastic round cell tumor and later was treated with exploratory laparotomy and resection of the tumor with no recurrence during a 6-month follow-up period. (Source: Clinical Case Reports)
Source: Clinical Case Reports - November 16, 2023 Category: General Medicine Authors: Sujan Bohara, Pinky Jha, Pawan Singh Bhat, Srijan Malla, Samikshya Karki, Saroj Kumar Jha, Sunil Basukala, Sushil Bahadur Rawal Tags: CASE REPORT Source Type: research

Intracranial desmoplastic small round cell tumor
Asian J Surg. 2023 Oct 5:S1015-9584(23)01563-4. doi: 10.1016/j.asjsur.2023.09.147. Online ahead of print.NO ABSTRACTPMID:37805326 | DOI:10.1016/j.asjsur.2023.09.147 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - October 7, 2023 Category: Surgery Authors: Wenjing Li Yimeng Kang Weijian Wang Yong Zhang Source Type: research

Desmoplastic Small Round Cell Tumor with Ovarian Involvement on [ < sup > 18 < /sup > F]FDG PET/CT
Rev Esp Med Nucl Imagen Mol (Engl Ed). 2023 Sep 21:S2253-8089(23)00074-5. doi: 10.1016/j.remnie.2023.09.002. Online ahead of print.NO ABSTRACTPMID:37741339 | DOI:10.1016/j.remnie.2023.09.002 (Source: Molecular Medicine)
Source: Molecular Medicine - September 23, 2023 Category: Molecular Biology Authors: Zhe Zheng Pengcheng Hu Yibo He Hongcheng Shi Source Type: research

Desmoplastic small round cell tumor with ovarian involvement on [ < sup > 18 < /sup > F]-FDG PET/CT
Rev Esp Med Nucl Imagen Mol (Engl Ed). 2023 Sep 22:S2253-8089(23)00074-5. doi: 10.1016/j.remnie.2023.09.002. Online ahead of print.NO ABSTRACTPMID:37741339 | DOI:10.1016/j.remnie.2023.09.002 (Source: Molecular Medicine)
Source: Molecular Medicine - September 23, 2023 Category: Molecular Biology Authors: Zhe Zheng Pengcheng Hu Yibo He Hongcheng Shi Source Type: research

CXCR4-Directed Imaging and Endoradiotherapy in Desmoplastic Small Round Cell Tumors
Conclusion: We validated CXCR4 as a diagnostic biomarker and a promising target for endoradiotherapy in DSRCT, demonstrated its feasibility, and provided the first evidence of its clinical efficacy. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 1, 2023 Category: Nuclear Medicine Authors: Hartlapp, I., Hartrampf, P. E., Serfling, S. E., Wild, V., Weich, A., Rasche, L., Roth, S., Rosenwald, A., Mihatsch, P. W., Hendricks, A., Wiegering, A., Wiegering, V., Hanscheid, H., Schirbel, A., Werner, R. A., Buck, A. K., Wester, H.-J., Einsele, H., K Tags: Clinical Investigations Source Type: research

Desmoplastic small round cell tumor of the liver: diagnosing a rare case on liver biopsy
Desmoplastic small round-cell tumors (DSRCT) frequently develop in the retroperitoneum, pelvis, omentum, and mesentery. Here, we present an unusual case of primary DSRCT in the liver. The patient was an 11-yea... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - July 29, 2023 Category: Pathology Authors: Xiao Feng, Jing Tao, Qiang Zhou, Yi-Dan Qiao, Le-Jian He and Nan Zhang Tags: Case Report Source Type: research

GSE200529 Dissociation Protocols used for Sarcoma Tissues Bias the Transcriptome observed in Single-cell and Single-nucleus RNA sequencing.
Contributors : Danh D Truong ; Vidya Gopalakrishnan ; Nancy Gordon ; Najat C Daw ; Joseph A LudwigSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo determine whether sarcomas – tumors of mesenchymal origin – are subject to the same technical artifacts, we profiled patient-derived tumor explants (PDXs) propagated from three aggressive subtypes: osteosarcoma, Ewing sarcoma (ES), desmoplastic small round cell tumor (DSRCT). Given the rarity of these sarcoma subtypes, we explored whether single-nuclei RNA-seq from more widely available archival frozen specimens could accurately be...
Source: GEO: Gene Expression Omnibus - July 21, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Genomic Breakpoint Characterization and Transcriptome Analysis of Metastatic, Recurrent Desmoplastic Small Round Cell Tumor
Sarcoma. 2023 Jul 6;2023:6686702. doi: 10.1155/2023/6686702. eCollection 2023.ABSTRACTDesmoplastic small round cell tumor (DSRCT) is a rare pediatric cancer caused by the EWSR1-WT1 fusion oncogene. Despite initial response to chemotherapy, DSRCT has a recurrence rate of over 80% leading to poor patient prognosis with a 5-year survival rate of only 15-25%. Owing to the rarity of DSRCT, sample scarcity is a barrier in understanding DSRCT biology and developing effective therapies. Utilizing a novel pair of primary and recurrent DSRCTs, we present the first map of DSRCT genomic breakpoints and the first comparison of gene exp...
Source: Sarcoma - July 17, 2023 Category: Cancer & Oncology Authors: Justin W Magrath Dane A Flinchum Alifiani B Hartono Ilon N Goldberg Madelyn Espinosa-Cotton Krzysztof Moroz Nai-Kong V Cheung Sean B Lee Source Type: research