Dentin Matrix Protein 1 Regulates Mineralization of MC3T3-E1 Cells via the TNAP-ANK-ENPP1 Axis
CONCLUSIONS: DMP1 regulated mineralization of MC3T3-E1 cells via the TNAP-ANK-ENPP1 axis and affected TNAP activity by two processes-rapid regulation of the Zn2+ transporter (ZnT) and transcriptional regulation of hysteresis. However, DMP1 may affect expression of ENPP1 and ANK only via hysteresis transcriptional regulation. DMP1, as a calcium trap or catalytic enzyme, appears to have a role in collagen mineralization.PMID:37380477 | DOI:10.1272/jnms.JNMS.2023_90-306 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - June 28, 2023 Category: Universities & Medical Training Authors: Jianmin Liu Juhua Zhao Zhi Li Hongmei Wang Binbin Wang Wei Liu Lei Zhou Source Type: research

Dentin Matrix Protein 1 Regulates Mineralization of MC3T3-E1 Cells via the TNAP-ANK-ENPP1 Axis
CONCLUSIONS: DMP1 regulated mineralization of MC3T3-E1 cells via the TNAP-ANK-ENPP1 axis and affected TNAP activity by two processes-rapid regulation of the Zn2+ transporter (ZnT) and transcriptional regulation of hysteresis. However, DMP1 may affect expression of ENPP1 and ANK only via hysteresis transcriptional regulation. DMP1, as a calcium trap or catalytic enzyme, appears to have a role in collagen mineralization.PMID:37380477 | DOI:10.1272/jnms.JNMS.2023_90-306 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - June 28, 2023 Category: Universities & Medical Training Authors: Jianmin Liu Juhua Zhao Zhi Li Hongmei Wang Binbin Wang Wei Liu Lei Zhou Source Type: research

Dentin Matrix Protein 1 Regulates Mineralization of MC3T3-E1 Cells via the TNAP-ANK-ENPP1 Axis
CONCLUSIONS: DMP1 regulated mineralization of MC3T3-E1 cells via the TNAP-ANK-ENPP1 axis and affected TNAP activity by two processes-rapid regulation of the Zn2+ transporter (ZnT) and transcriptional regulation of hysteresis. However, DMP1 may affect expression of ENPP1 and ANK only via hysteresis transcriptional regulation. DMP1, as a calcium trap or catalytic enzyme, appears to have a role in collagen mineralization.PMID:37380477 | DOI:10.1272/jnms.JNMS.2023_90-306 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - June 28, 2023 Category: Universities & Medical Training Authors: Jianmin Liu Juhua Zhao Zhi Li Hongmei Wang Binbin Wang Wei Liu Lei Zhou Source Type: research

Dentin Matrix Protein 1 Regulates Mineralization of MC3T3-E1 Cells via the TNAP-ANK-ENPP1 Axis
CONCLUSIONS: DMP1 regulated mineralization of MC3T3-E1 cells via the TNAP-ANK-ENPP1 axis and affected TNAP activity by two processes-rapid regulation of the Zn2+ transporter (ZnT) and transcriptional regulation of hysteresis. However, DMP1 may affect expression of ENPP1 and ANK only via hysteresis transcriptional regulation. DMP1, as a calcium trap or catalytic enzyme, appears to have a role in collagen mineralization.PMID:37380477 | DOI:10.1272/jnms.JNMS.2023_90-306 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - June 28, 2023 Category: Universities & Medical Training Authors: Jianmin Liu Juhua Zhao Zhi Li Hongmei Wang Binbin Wang Wei Liu Lei Zhou Source Type: research

Dentin Matrix Protein 1 Regulates Mineralization of MC3T3-E1 Cells via the TNAP-ANK-ENPP1 Axis
CONCLUSIONS: DMP1 regulated mineralization of MC3T3-E1 cells via the TNAP-ANK-ENPP1 axis and affected TNAP activity by two processes-rapid regulation of the Zn2+ transporter (ZnT) and transcriptional regulation of hysteresis. However, DMP1 may affect expression of ENPP1 and ANK only via hysteresis transcriptional regulation. DMP1, as a calcium trap or catalytic enzyme, appears to have a role in collagen mineralization.PMID:37380477 | DOI:10.1272/jnms.JNMS.2023_90-306 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - June 28, 2023 Category: Universities & Medical Training Authors: Jianmin Liu Juhua Zhao Zhi Li Hongmei Wang Binbin Wang Wei Liu Lei Zhou Source Type: research

Dentin Matrix Protein 1 Regulates Mineralization of MC3T3-E1 Cells via the TNAP-ANK-ENPP1 Axis
CONCLUSIONS: DMP1 regulated mineralization of MC3T3-E1 cells via the TNAP-ANK-ENPP1 axis and affected TNAP activity by two processes-rapid regulation of the Zn2+ transporter (ZnT) and transcriptional regulation of hysteresis. However, DMP1 may affect expression of ENPP1 and ANK only via hysteresis transcriptional regulation. DMP1, as a calcium trap or catalytic enzyme, appears to have a role in collagen mineralization.PMID:37380477 | DOI:10.1272/jnms.JNMS.2023_90-306 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - June 28, 2023 Category: Universities & Medical Training Authors: Jianmin Liu Juhua Zhao Zhi Li Hongmei Wang Binbin Wang Wei Liu Lei Zhou Source Type: research

Dentin Matrix Protein 1 Regulates Mineralization of MC3T3-E1 Cells via the TNAP-ANK-ENPP1 Axis
CONCLUSIONS: DMP1 regulated mineralization of MC3T3-E1 cells via the TNAP-ANK-ENPP1 axis and affected TNAP activity by two processes-rapid regulation of the Zn2+ transporter (ZnT) and transcriptional regulation of hysteresis. However, DMP1 may affect expression of ENPP1 and ANK only via hysteresis transcriptional regulation. DMP1, as a calcium trap or catalytic enzyme, appears to have a role in collagen mineralization.PMID:37380477 | DOI:10.1272/jnms.JNMS.2023_90-306 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - June 28, 2023 Category: Universities & Medical Training Authors: Jianmin Liu Juhua Zhao Zhi Li Hongmei Wang Binbin Wang Wei Liu Lei Zhou Source Type: research

Dentin Matrix Protein 1 Regulates Mineralization of MC3T3-E1 Cells via the TNAP-ANK-ENPP1 Axis
CONCLUSIONS: DMP1 regulated mineralization of MC3T3-E1 cells via the TNAP-ANK-ENPP1 axis and affected TNAP activity by two processes-rapid regulation of the Zn2+ transporter (ZnT) and transcriptional regulation of hysteresis. However, DMP1 may affect expression of ENPP1 and ANK only via hysteresis transcriptional regulation. DMP1, as a calcium trap or catalytic enzyme, appears to have a role in collagen mineralization.PMID:37380477 | DOI:10.1272/jnms.JNMS.2023_90-306 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - June 28, 2023 Category: Universities & Medical Training Authors: Jianmin Liu Juhua Zhao Zhi Li Hongmei Wang Binbin Wang Wei Liu Lei Zhou Source Type: research

Dentin Matrix Protein 1 Regulates Mineralization of MC3T3-E1 Cells via the TNAP-ANK-ENPP1 Axis
CONCLUSIONS: DMP1 regulated mineralization of MC3T3-E1 cells via the TNAP-ANK-ENPP1 axis and affected TNAP activity by two processes-rapid regulation of the Zn2+ transporter (ZnT) and transcriptional regulation of hysteresis. However, DMP1 may affect expression of ENPP1 and ANK only via hysteresis transcriptional regulation. DMP1, as a calcium trap or catalytic enzyme, appears to have a role in collagen mineralization.PMID:37380477 | DOI:10.1272/jnms.JNMS.2023_90-306 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - June 28, 2023 Category: Universities & Medical Training Authors: Jianmin Liu Juhua Zhao Zhi Li Hongmei Wang Binbin Wang Wei Liu Lei Zhou Source Type: research

Dentin Matrix Protein 1 Regulates Mineralization of MC3T3-E1 Cells via the TNAP-ANK-ENPP1 Axis
CONCLUSIONS: DMP1 regulated mineralization of MC3T3-E1 cells via the TNAP-ANK-ENPP1 axis and affected TNAP activity by two processes-rapid regulation of the Zn2+ transporter (ZnT) and transcriptional regulation of hysteresis. However, DMP1 may affect expression of ENPP1 and ANK only via hysteresis transcriptional regulation. DMP1, as a calcium trap or catalytic enzyme, appears to have a role in collagen mineralization.PMID:37380477 | DOI:10.1272/jnms.JNMS.2023_90-306 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - June 28, 2023 Category: Universities & Medical Training Authors: Jianmin Liu Juhua Zhao Zhi Li Hongmei Wang Binbin Wang Wei Liu Lei Zhou Source Type: research

Dentin Matrix Protein 1 Regulates Mineralization of MC3T3-E1 Cells via the TNAP-ANK-ENPP1 Axis
CONCLUSIONS: DMP1 regulated mineralization of MC3T3-E1 cells via the TNAP-ANK-ENPP1 axis and affected TNAP activity by two processes-rapid regulation of the Zn2+ transporter (ZnT) and transcriptional regulation of hysteresis. However, DMP1 may affect expression of ENPP1 and ANK only via hysteresis transcriptional regulation. DMP1, as a calcium trap or catalytic enzyme, appears to have a role in collagen mineralization.PMID:37380477 | DOI:10.1272/jnms.JNMS.2023_90-306 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - June 28, 2023 Category: Universities & Medical Training Authors: Jianmin Liu Juhua Zhao Zhi Li Hongmei Wang Binbin Wang Wei Liu Lei Zhou Source Type: research

Dentin Matrix Protein 1 Regulates Mineralization of MC3T3-E1 Cells via the TNAP-ANK-ENPP1 Axis
CONCLUSIONS: DMP1 regulated mineralization of MC3T3-E1 cells via the TNAP-ANK-ENPP1 axis and affected TNAP activity by two processes-rapid regulation of the Zn2+ transporter (ZnT) and transcriptional regulation of hysteresis. However, DMP1 may affect expression of ENPP1 and ANK only via hysteresis transcriptional regulation. DMP1, as a calcium trap or catalytic enzyme, appears to have a role in collagen mineralization.PMID:37380477 | DOI:10.1272/jnms.JNMS.2023_90-306 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - June 28, 2023 Category: Universities & Medical Training Authors: Jianmin Liu Juhua Zhao Zhi Li Hongmei Wang Binbin Wang Wei Liu Lei Zhou Source Type: research

Dentin Matrix Protein 1 Regulates Mineralization of MC3T3-E1 Cells via the TNAP-ANK-ENPP1 Axis
CONCLUSIONS: DMP1 regulated mineralization of MC3T3-E1 cells via the TNAP-ANK-ENPP1 axis and affected TNAP activity by two processes-rapid regulation of the Zn2+ transporter (ZnT) and transcriptional regulation of hysteresis. However, DMP1 may affect expression of ENPP1 and ANK only via hysteresis transcriptional regulation. DMP1, as a calcium trap or catalytic enzyme, appears to have a role in collagen mineralization.PMID:37380477 | DOI:10.1272/jnms.JNMS.2023_90-306 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - June 28, 2023 Category: Universities & Medical Training Authors: Jianmin Liu Juhua Zhao Zhi Li Hongmei Wang Binbin Wang Wei Liu Lei Zhou Source Type: research

Dentin Matrix Protein 1 Regulates Mineralization of MC3T3-E1 Cells via the TNAP-ANK-ENPP1 Axis
CONCLUSIONS: DMP1 regulated mineralization of MC3T3-E1 cells via the TNAP-ANK-ENPP1 axis and affected TNAP activity by two processes-rapid regulation of the Zn2+ transporter (ZnT) and transcriptional regulation of hysteresis. However, DMP1 may affect expression of ENPP1 and ANK only via hysteresis transcriptional regulation. DMP1, as a calcium trap or catalytic enzyme, appears to have a role in collagen mineralization.PMID:37380477 | DOI:10.1272/jnms.JNMS.2023_90-306 (Source: Journal of Nippon Medical School)
Source: Journal of Nippon Medical School - June 28, 2023 Category: Universities & Medical Training Authors: Jianmin Liu Juhua Zhao Zhi Li Hongmei Wang Binbin Wang Wei Liu Lei Zhou Source Type: research

A single-centre retrospective case series of Anakinra for incident calcium pyrophosphate deposition disease
This study adds to the small amount of retrospective data present about the use of anakinra in CPPD. We observed a rapid response to anakinra in our cohort with minimal adverse drug reactions.Key Points•Treatment of CPPD with anakinra appears to be rapidly efficacious without safety concerns. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - June 16, 2023 Category: Rheumatology Source Type: research