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A Phase I/II Clinical Trial to evaluate the efficacy of baricitinib to prevent respiratory insufficiency progression in onco-hematological patients affected with COVID19: A structured summary of a study protocol for a randomised controlled trial
AbstractObjectivesBaricitinib is supposed to have a double effect on SARS-CoV2 infection. Firstly, it reduces the inflammatory response through the inhibition of the Januse-Kinase signalling transducer and activator of transcription (JAK-STAT) pathway. Moreover, it reduces the receptor mediated viral endocytosis by AP2-associated protein kinase 1 (AAK1) inhibition. We propose the use of baricinitib to prevent the progression of the respiratory insufficiency in SARS-CoV2 pneumonia in onco-haematological patients. In this phase Ib/II study, the primary objective in the safety cohort is to describe the incidence of severe adv...
Source: Trials - February 5, 2021 Category: Research Source Type: clinical trials

Initial Manifestations of Congestive Heart Failure in Patients With NSTEACS
Condition: Acute Heart Failure, Non-ST-segment Elevation Acute Coronary Syndrome Intervention: Sponsors: National Medical Research Center for Therapy and Preventive Medicine; City clinical hospital named after A. K. Eramishantsev Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 4, 2021 Category: Research Source Type: clinical trials

Evaluation of the efficacy and safety of inhaled magnesium sulphate in combination with standard treatment in patients with moderate or severe COVID-19: A structured summary of a study protocol for a randomised controlled trial
AbstractObjectivesBasic and clinical studies have shown that magnesium sulphate ameliorates lung injury and controls asthma attacks by anti-inflammatory and bronchodilatory effects. Both intravenous and inhaled magnesium sulphate have a clinical impact on acute severe asthma by inhibition of airway smooth muscle contraction. Besides, magnesium sulphate can dilate constricted pulmonary arteries and reduce pulmonary artery resistance. However, it may affect systemic arteries when administered intravenously. A large number of patients with covid-19 admitted to the hospital suffer from pulmonary involvement. COVID-19 can cause...
Source: Trials - January 18, 2021 Category: Research Source Type: clinical trials

Safety and Efficacy of Imatinib for Hospitalized Adults with COVID-19: A structured summary of a study protocol for a randomised controlled trial
In this study, patients with confirmed positive COVID-19 tests receive imatinib for a total of 14 days; 400 mg orally daily Days 1-14. Imatinib 400 mg tablets will be encapsulated using size 000 capsules and cellulose microcrystalline filler. For patients on ventilator or ECMO, imatinib will be given as oral suspension (40 mg/mL). To make the oral suspension, imatinib tablets will be crushed and mixed in Ora-sweet solution to yield a concentration of 40 mg/mL suspension by pharmacy. Additionally, in the absence of supportive microbiological testing results, we confirm that the in-use stability period for the prepared imati...
Source: Trials - October 28, 2020 Category: Research Source Type: clinical trials

The clinical effect of Nano micelles containing curcumin as a therapeutic supplement in patients with COVID-19 and the immune responses balance changes following treatment: A structured summary of a study protocol for a randomised controlled trial
This study is conducted as a prospective, placebo-controlled with parallel group, single-center randomized clinical trial on COVID-19 patients.ParticipantsPatients are selected from the COVID-19 ward of Shahid Mohammadi Hospital in Bandar Abbas, Iran.Inclusion criteria:1. Real time PCR-approved positive COVID-19 test.2. Both gender3. Age between 18 and 75 years4. Signing a written consent5. Lack of participation in other clinical trialsExclusion criteria:1. Pregnancy or lactation2. Allergy to turmeric or curcumin3. Smoking4. Patient connected to the ventilator5. SaO2 less than 90% or PaO2 less than 8 kPa6. Having comorbidi...
Source: Trials - October 22, 2020 Category: Research Source Type: clinical trials

SCD for CRS in Congestive Heart Failure (CHF) (No Left Ventricular Assist Device)
Conditions: Heart Failure; Chronic Systolic Heart Failure; Renal Failure; Cardiorenal Syndrome Intervention: Device: Selective Cytopheretic Device Sponsor: Keith Aaronson, MD Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 19, 2020 Category: Research Source Type: clinical trials