PROTECT Trial: A cluster-randomized study with hydroxychloroquine versus observational support for prevention or early-phase treatment of Coronavirus disease (COVID-19): A structured summary of a study protocol for a randomized controlled trial
This study is open label.Numbers to be randomized (sample size)For Group 1, a sample size of about 2000 SARS-CoV-2-exposed subjects such as household members and/or contacts of COVID-19 patients will take part in the study. Assuming around 1.5-2.0 asymptomatic household members and/or contacts for each COVID-19 patient, we expect to identify approximately 1000-1300 COVID-19 index cases to be randomized. An interim analysis on efficacy is planned using standard alpha-spending function.For Group 2, sufficient power for primary objective (negative swab within 14 days of randomization) will be reached given a sample size of 30...
Source: Trials - July 30, 2020 Category: Research Source Type: clinical trials

Nesiritide for Ventilated Congestive Heart Failure
Conditions:   Congestive Heart Failure;   Mechanical Ventilation;   Using Nesiritide;   Venous Return;   Cardiac Function Intervention:   Drug: Nesiritide Sponsor:   Shanghai Zhongshan Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 2, 2020 Category: Research Source Type: clinical trials