Not So Brilliant? Feds Probe AstraZeneca Over Brilinta Trial Data
Six months after a medical journal raised troubling questions about the reliability of a key study that was used to win approval for its Brilinta bloodthinner, AstraZeneca (AZN) says that the US Department of Justice has recently opened an inquiry into the trial, according to a filing with the US Securities and Exchange Commission. The disclosure was made in the most recent earnings report that was released today (see page 28).
An analysis last April in The International Journal of Cardiology found a host of disturbing issues with the so-called Plato trial. Nearly three years ago, the FDA questioned aspects of the study an...
Source: Pharmalot - October 31, 2013 Category: Pharma Commentators Authors: esilverman Source Type: blogs
On The Pulse - 04th October 2013
Smokers get more benefit from clopidogrel (Source: OnMedica Blogs)
Source: OnMedica Blogs - October 5, 2013 Category: Health Medicine and Bioethics Commentators Source Type: blogs
Medical Mispronunciations and Misspelled Words: The Definitive List.
Hearing medical mispronunciations and seeing misspelled words are an under appreciated joy of working in healthcare. Physicians often forget just how alien the language of medicine is to people who don't live it everyday. The best part about being a physician is not helping people recover from critical illness. The best part is not about listening and understanding with compassion and empathy. Nope, the best part about being a physician is hearing patients and other healthcare providers butcher the language of medicine and experiencing great entertainment in the process. Doctors c...
Source: The Happy Hospitalist - October 2, 2013 Category: Internists and Doctors of Medicine Authors: Tamer Mahrous Source Type: blogs
Pharmalot... Pharmalittle... Good Morning
Rise and shine, everyone. Another sunny day is on the way. Moreover, we are graced with a deliciously cool breeze this morning, as well. All in all, a lovely atmosphere for attacking the workload, yes? So no need to delay. Grab a cup of something stimulating, reach for your to-do list and make a good effort. Meanwhile, here are a few tidbits to start you off. Have a swell day and do stay in touch...
Dementia Drugs Do Not Help Mild Cognitive Impairment (MedPage Today)
UK Docs Warned Of Hemophilia Risk With Sanofi's Plavix (Pharma Times)
Chiesi To Buy Rest Of Cornerstone Therapeutics (Reuters)
EU Approves Sanofi MS Drug Lemt...
Source: Pharmalot - September 17, 2013 Category: Pharma Commentators Authors: esilverman Source Type: blogs
Drug eluting stent
Drug used for coating coronary stents to reduce restenosis:
a) Atorvastatin
b) Aspirin
c) Sirolimus
d) Clopidogrel
Correct answer: c) Sirolimus
Sirolimus is an antimalignant drug which is used in drug eluting stents which reduces neo-intimal proliferation, the important cause of in stent restenosis after coronary angioplasty with stenting. All the other drugs are helpful in reducing the chance of progression of coronary artery disease and are invariably given after coronary stenting, but are not used for coating drug eluting stents. (Source: Cardiophile MD)
Source: Cardiophile MD - September 5, 2013 Category: Cardiology Authors: Prof. Dr. Johnson Francis MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
What's hot at ESC 2013; German CoreValve use on hold; ESC hot line ACCOAST was halted; Public Citizen to FDA: No more clopidogrel one year post-DES
(Source: Blogs@theHeart.org)
Source: Blogs@theHeart.org - August 30, 2013 Category: Cardiology Authors: theheart.org Tags: This week in cardiology from heartwire Source Type: blogs
FDA Should Boost Plavix Warning For Stent Implants: Watchdog
A consumer watchdog has petitioned the FDA to add a Black Box warning to the widely used Plavix bloodthinner, citing evidence that usage for more than a year after having a drug-eluting stent implanted may lead to fatal bleeding without providing any additional benefits.
In its petition, Public Citizen points to randomized controlled trials and other studies indicating that taking Plavix for more than a year after a stent implant does not reduce the chance of death from cardiac causes, myocardial infarction or other thrombotic events, compared to usage for less than a year.
“The research shows that using this drug for mo...
Source: Pharmalot - August 21, 2013 Category: Pharma Commentators Authors: esilverman Source Type: blogs
Your patient on Plavix breaks a hip. Now what?
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - August 18, 2013 Category: Internists and Doctors of Medicine Tags: hospital medicine cardiovascular Source Type: blogs
Statins protective against Parkinson's: More evidence; abandoning off-pump CABG surgery?; prasugrel 5 mg, clopidogrel similarly safe, effective; perioperative beta-blocker controversy
(Source: Blogs@theHeart.org)
Source: Blogs@theHeart.org - August 2, 2013 Category: Cardiology Authors: theheart.org Tags: This week in cardiology from heartwire Source Type: blogs
Man in his 60's with very subtle ECG and pain not controlled with medical therapy
A male in his 60's presented 30 minutes after the onset of crushing substernal chest pain. Medics recorded 2 ECGs, one before and one after sublingual NTG, and both are similar to the first ED ECG. The patient had never had pain like this before. The pain improved from 9/10 to 3/10 after NTG. Here is the initial ED ECG:QRS axis = 11, T-wave axis = 13. There are very subtle signs of ischemia here: minimal ST elevation in I and aVL with minimal reciprocal ST depression in lead III. Most specific is the abnormal ST segment and T-wave in aVF: it is downsloping with a subtly biphasic (down-up...
Source: Dr. Smith's ECG Blog - August 1, 2013 Category: Cardiology Authors: Steve Smith Source Type: blogs
Learning crucial cardiology lessons from the patietns !
One of my otherwise well behaving patient , suddenly asked me this question , before leaving my clinic after a 15 minute consult .
Doctor . . . I am taking the clopidgrel and aspirin for 5 years like a vitamin tablet . . . is that all right doctor
I just got curious, I checked the prescription again . Yeh , he was right !
I have been mechanically writing Tablet Clopitab A since 2008 !
For what ?
Some sort of CAD ! Was it for a ACS . No . . . it was for chronic stable angina No PCI, . . . no DES ?
Why the hell he is taking dual anti-platelet therapy for 5 years ?
Some body , s...
Source: Dr.S.Venkatesan MD - July 31, 2013 Category: Cardiology Authors: dr s venkatesan Tags: bio ethics cardiology-ethics Clinical cardiology general medicine cardiologist cartoon cardiology cartoons cardiology consultations cardiology medical consultations cartoon medical clopidogrel doctor patient relationship humour based Source Type: blogs
