Early Results: Antiplatelet Drug Cangrelor Appears Effective For PCI
The experimental antiplatelet drug cangrelor was superior to traditional clopidogrel in reducing ischemic events at 48 hours in PCI patients, according to the Medicines Company, which is developing the drug. The company today announced positive results from the phase 3 CHAMPION PHOENIX trial, a randomized, double-blind study comparing intravenous cangrelor to oral clopidogrel in PCI patients. The primary endpoint was the composite of death, MI, revascularization and stent thrombosis at 48 hours. Click here to read the full story on Forbes. (Source: CardioBrief)
Source: CardioBrief - January 8, 2013 Category: Cardiology Authors: Larry Husten Tags: Interventional Cardiology & Surgery Antiplatelet drug Cangrelor clopidogrel Conventional PCI Medicines Company Stent Source Type: blogs
Pharma Deals North of $10 Billion Seen Returning in 2013 - Bloomberg
Get ready for the return of the $10 billion-plus drug deal. Pharmaceutical companies including Pfizer Inc. (PFE) and Bristol- Myers Squibb Co. (BMY) have spent the last several years digesting earlier acquisitions, refocusing their product development and setting aside cash in anticipation of expiring patents. Now, the expectation is they’re ready to start buying again. Led by Pfizer, in New York, and Whitehouse Station, New Jersey-based Merck & Co. (MRK), five of the largest U.S. drugmakers had more than $70 billion in cash, near cash and short-term investments at the end of the third quarter. ...
Source: PharmaGossip - January 7, 2013 Category: Pharma Commentators Authors: insider Source Type: blogs
Right Bundle Branch Block with New Anterior ST elevation
An elderly female with no known history of CAD presented to the ED as a walk-in with vomiting and upper abdominal discomfort. The following ECG was recorded at t = 0:There is sinus rhythm with Right Bundle Branch Block and ST elevation in leads V1 and V2, suspicious for STEMI. The computerized QRS duration is 138 ms. A previous ECG was found:There is an RSR' with right ventricular conduction delay and downsloping ST depression in V1 that is reminiscent of Brugada pattern. The computerized QRS duration is 84 ms. The ST elevation is confirmed to be new.The cath lab was activated but the interven...
Source: Dr. Smith's ECG Blog - January 4, 2013 Category: Cardiology Authors: Steve Smith Source Type: blogs
Precordial ST depression. What is the diagnosis?
A middle aged male with no h/o CAD presented with one week of crescendo exertional angina, and had chest pain at the time of the first ECG:Here is the patient's previous ECG:NormalHere is the patient's presenting ED ECG:What do you think?There is isolated ST depression in precordial leads, deeper in V2 - V4 than in V5 or V6. There is no ST elevation. Precordial ST depression may be subendocardial ischemia or posterior STEMI. How can we tell the difference? See the list below.If you thought it might be a posterior STEMI, then you might have ordered a posterior ECG [change leads V4...
Source: Dr. Smith's ECG Blog - January 1, 2013 Category: Cardiology Authors: Steve Smith Source Type: blogs
The LITFL Review 089
Welcome to the festive 89th edition!
The LITFL Review is your regular and reliable source for the highest highlights, sneakiest sneak peaks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the best and brightest from the blogosphere, the podcast video/audiosphere and the rest of the Web 2.0 social media jungle to find the most fantastic EM/CC FOAM (Free Open Access Meducation) around.
The Most Fair Dinkum Ripper Beaut of the Week
The Skeptics Guide to Emergency Medicine
Top spot this week is taken out by The Skeptics Guide to Emergency M...
Source: Life in the Fast Lane - January 1, 2013 Category: Emergency Medicine Doctors Authors: Kane Guthrie Tags: Education eLearning Emergency Medicine Featured Health Intensive Care LITFL review LITFL R/V Source Type: blogs
The LITFL Review 089
Welcome to the festive 89th edition!
The LITFL Review is your regular and reliable source for the highest highlights, sneakiest sneak peaks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the best and brightest from the blogosphere, the podcast video/audiosphere and the rest of the Web 2.0 social media jungle to find the most fantastic EM/CC FOAM (Free Open Access Meducation) around.
The Most Fair Dinkum Ripper Beaut of the Week
The Skeptics Guide to Emergency Medicine
Top spot this week is taken out by The Skeptics Guide to Emergency M...
Source: Life in the Fast Lane - January 1, 2013 Category: Emergency Medicine Doctors Authors: Kane Guthrie Tags: Education eLearning Emergency Medicine Featured Health Intensive Care LITFL review LITFL R/V Source Type: blogs
