Asymmetric Catalysis via Cyclic, Aliphatic Oxocarbenium Ions - Journal of the American Chemical Society (ACS Publications)
A direct enantioselective synthesis of substituted oxygen heterocycles from lactol acetates and enolsilanes has been realized using a highly reactive and confined imidodiphosphorimidate (IDPi) catalyst. (Source: Organometallic Current)
Source: Organometallic Current - February 15, 2017 Category: Chemistry Tags: Asymmetric organocatalysis Phosphoramides Source Type: blogs
Direct Asymmetric Vinylogous and Bisvinylogous Mannich-Type Reaction Catalyzed by a Copper(I) Complex - Journal of the American Chemical Society (ACS Publications)
A direct catalytic asymmetric vinylogous Mannich-type reaction has been disclosed in good yield, excellent regio-, diastereo- and enantioselectivity. The key to control the regioselectivity is the combination of a bulkyN-acylpyrazole and a bulky bisphosphine ligand. (Source: Organometallic Current)
Source: Organometallic Current - February 15, 2017 Category: Chemistry Tags: Asymmetric Cu catalyzed Mannich Reaction Source Type: blogs
Hybrid Catalysis Enabling Room-Temperature Hydrogen Gas Release from N-Heterocycles and Tetrahydronaphthalenes - Journal of the American Chemical Society (ACS Publications)
Hybrid catalyst systems to achieve acceptorless dehydrogenation ofN-heterocycles and tetrahydronaphthalenes —model substrates for liquid organic hydrogen carriers—were developed. (Source: Organometallic Current)
Source: Organometallic Current - February 15, 2017 Category: Chemistry Tags: Dehydrogenation Heterocycles Pd Catalyzed Source Type: blogs
Highly Regio- and Enantioselective Vicinal Dihalogenation of Allyl Amides - Journal of the American Chemical Society (ACS Publications)
We report a highly regio-, diastereo- and enantioselective vicinal dihalogenation of allyl amides.E- andZ-alkenes with both aryl and alkyl substituents were compatible with this chemistry. This is the result of exquisite catalyst controlled regioselectivity enabling use of electronically unbiased substrates. (Source: Organometallic Current)
Source: Organometallic Current - February 15, 2017 Category: Chemistry Tags: Halogenation Source Type: blogs
Rh(III)-Catalyzed meta-C –H Olefination Directed by a Nitrile Template - Journal of the American Chemical Society (ACS Publications)
A range of Rh(III)-catalyzedortho-C –H functionalizations have been developed; however, extension of this reactivity to remote C–H functionalizations through large-ring rhodacyclic intermediates has yet to be demonstrated. Herein we report the first example of the use of a U-shaped nitrile template to direct Rh(III)-catalyzed remotemeta-C –H activation via a postulated 12-membered macrocyclic intermediate. (Source: Organometallic Current)
Source: Organometallic Current - February 15, 2017 Category: Chemistry Tags: C-H Olefination meta-Selective Rh Catalyzed Source Type: blogs
Enantioselective Syntheses of Furan Atropisomers by an Oxidative Central-to-Axial Chirality Conversion Strategy - Journal of the American Chemical Society (ACS Publications)
For the first time, enantiomerically enriched atropoisomeric furans have been accessed using a central-to-axial chirality conversion strategy. Hence, oxidation of the enantioenriched dihydrofuran precursors gave rise to axially chiral furans with high enantiopurities accounting from excellent conversion percentages (cp) in most cases. (Source: Organometallic Current)
Source: Organometallic Current - February 15, 2017 Category: Chemistry Tags: Enantioselective organocatalysis Source Type: blogs
Asymmetric Copper Hydride-Catalyzed Markovnikov Hydrosilylation of Vinylarenes and Vinyl Heterocycles - Journal of the American Chemical Society (ACS Publications)
We report a highly enantioselective CuH-catalyzed Markovnikov hydrosilylation of vinylarenes and vinyl heterocycles. Density functional theory calculations support a mechanism proceeding by hydrocupration followed by σ-bond metathesis with a hydrosilane. (Source: Organometallic Current)
Source: Organometallic Current - February 15, 2017 Category: Chemistry Tags: Asymmetric Cu catalyzed Hydrosilylation Markovnikov Source Type: blogs
Light ‐Driven Enantioselective Organocatalytic β‐Benzylation of Enals
: A photochemical organocatalytic strategy for the direct enantioselective β‐benzylation of α,β‐unsaturated aldehydes is reported. The chemistry capitalizes upon the light‐triggered enolization of 2‐alkyl‐benzophenones... (Source: Organometallic Current)
Source: Organometallic Current - February 10, 2017 Category: Chemistry Tags: organocatalysis Source Type: blogs
Direct Syn Addition of Two Silicon Atoms to a C ≡C Triple Bond by Si−Si Bond Activation: Access to Reactive Disilylated Olefins
: A catalytic intramolecular silapalladation of alkynes affords, in good yields and stereoselectively, syn ‐disilylated heterocycles of different chemical structure and size. When applied to silylethers,... (Source: Organometallic Current)
Source: Organometallic Current - February 10, 2017 Category: Chemistry Tags: Pd Catalyzed Rh Catalyzed Silylation Source Type: blogs
Enolonium Species —Umpoled Enolates
: Enolonium species/iodo(III)enolates of carbonyl compounds have been suggested to be intermediates in a wide variety of hypervalent iodine induced chemical transformations of ketones, including α‐C−O, α‐C−N,... (Source: Organometallic Current)
Source: Organometallic Current - February 10, 2017 Category: Chemistry Tags: Umpolung Source Type: blogs
Review: Indenylmetal Catalysis in Organic Synthesis
Indenylmetal Catalysis in Organic Synthesis: Synthetic organic chemists have a long ‐standing appreciation for transition metal cyclopentadienyl complexes, of which many have been used as catalysts for organic transformations. Much less well known... (Source: Organometallic Current)
Source: Organometallic Current - February 10, 2017 Category: Chemistry Tags: Reviews Source Type: blogs
Electrocatalytic Oxidant ‐Free Dehydrogenative C−H/S−H Cross‐Coupling
: An environmentally friendly electrocatalytic protocol has been developed for dehydrogenative C −H/S−H cross‐coupling. This method enabled C−S bond formation under catalyst‐ and oxidant‐free conditions.... (Source: Organometallic Current)
Source: Organometallic Current - February 10, 2017 Category: Chemistry Tags: C-S Bond Forming Dehydrogenation Electrochemical Source Type: blogs
2016 in news: The science events that shaped the year
Nature|News2016 in news: The science events that shaped the yearClimate accords, controversial assisted reproduction and the CRISPR patent battle are among the year's top stories. Alison Abbott, Declan Butler, Davide Castelvecchi, Daniel Cressey, Elizabeth Gibney, Heidi Ledford, Jane J Lee, Lauren Morello, Sara Reardon, Jeff Tollefson&Alexandra Witze (Source: Organometallic Current)
Source: Organometallic Current - January 2, 2017 Category: Chemistry Tags: news Source Type: blogs
2016 in pictures: The best science images of the year
Nature|News2016 in pictures: The best science images of the year Includes storms from space, southern stars and a striking cell. Daniel Cressey (Source: Organometallic Current)
Source: Organometallic Current - January 2, 2017 Category: Chemistry Tags: news Source Type: blogs
Areas to watch in 2017
Science23 Dec 2016 : 1524Science's picks for Areas to watch in 2017 are human embryo research, Zika vaccine trials, the search for Planet Nine, and the impacts on research of the U.S. election and "Brexit" vote. (Source: Organometallic Current)
Source: Organometallic Current - January 2, 2017 Category: Chemistry Tags: news Source Type: blogs
