Metal- and Reagent-Free Intramolecular Oxidative Amination of Tri- and Tetrasubstituted Alkenes - Journal of the American Chemical Society (ACS Publications)
A metal- and reagent-free, electrochemical intramolecular oxidative amination reaction of tri- and tetrasubstituted alkenes has been developed. (Source: Organometallic Current)
Source: Organometallic Current - February 21, 2017 Category: Chemistry Tags: Amination Anodic Oxidation Electrochemical Metal free Source Type: blogs
Palladium ‐Catalyzed Direct Stereoselective Synthesis of Deoxyglycosides from Glycals
: Palladium(II) in combination with a monodentate phosphine ligand enables the unprecedented direct and α‐stereoselective catalytic synthesis of deoxyglycosides from glycals. Initial mechanistic studies... (Source: Organometallic Current)
Source: Organometallic Current - February 20, 2017 Category: Chemistry Tags: Carbohydrates Pd Catalyzed Source Type: blogs
Palladium ‐Catalyzed Oxidative Cascade Carbonylative Spirolactonization of Enallenols
: A highly selective palladium ‐catalyzed oxidative carbonylation/carbocyclization/alkoxycarbonylation of enallenols to afford spirolactones bearing an all‐carbon quaternary center was developed. This transformation... (Source: Organometallic Current)
Source: Organometallic Current - February 20, 2017 Category: Chemistry Tags: Carbon monoxide Carbonylation lactonization Pd Catalyzed Spirocycles Source Type: blogs
Palladium-Catalyzed C(sp3) —H Oxygenation via Electrochemical Oxidation - Journal of the American Chemical Society (ACS Publications)
previously reported oxidants possess significant disadvantages, including poor atom economy, high cost, and the formation of undesired byproducts. To overcome these issues, we report an electrochemical strategy that takes advantage of anodic oxidation of PdII to induce selective C —O reductive elimination with a variety of oxyanion coupling partners. (Source: Organometallic Current)
Source: Organometallic Current - February 20, 2017 Category: Chemistry Tags: Anodic Oxidation C-H Oxygenation Electrochemical Pd Catalyzed Source Type: blogs
Unified Total Synthesis of Madangamines A, C, and E - Journal of the American Chemical Society (ACS Publications)
A stereodivergent strategy for the synthesis of skipped dienes is developed. The method consists of hydroboration of allenes and Migita –Kosugi–Stille coupling, which allows for access to all four possible stereoisomers of the skipped dienes. (Source: Organometallic Current)
Source: Organometallic Current - February 17, 2017 Category: Chemistry Tags: Total synthesis Source Type: blogs
An Operationally Simple and Mild Oxidative Homocoupling of Aryl Boronic Esters To Access Conformationally Constrained Macrocycles - Journal of the American Chemical Society (ACS Publications)
Constrained macrocyclic scaffolds are recognized as challenging synthetic motifs with few general macrocyclization methods capable of accessing these types of systems. Here we report an oxidative boronic ester homocoupling reaction as a mild method for the synthesis of strained and conformationally restricted macrocycles. (Source: Organometallic Current)
Source: Organometallic Current - February 17, 2017 Category: Chemistry Tags: Macrocyclization Pd Catalyzed Source Type: blogs
Visible Light Copper Photoredox-Catalyzed Aerobic Oxidative Coupling of Phenols and Terminal Alkynes: Regioselective Synthesis of Functionalized Ketones via C ≡C Triple Bond Cleavage - Journal of the American Chemical Society (ACS Publications)
Direct oxidative coupling of phenols and terminal alkynes was achieved at room temperature by a visible-light-mediated copper-catalyzed photoredox process. (Source: Organometallic Current)
Source: Organometallic Current - February 17, 2017 Category: Chemistry Tags: Cu catalyzed Photoredox Catalysis Visible light Source Type: blogs
Oxygen Activated, Palladium Nanoparticle Catalyzed, Ultrafast Cross ‐Coupling of Organolithium Reagents
: The discovery of an ultrafast cross ‐coupling of alkyl‐ and aryllithium reagents with a range of aryl bromides is presented. The essential role of molecular oxygen to form the active palladium catalyst... (Source: Organometallic Current)
Source: Organometallic Current - February 15, 2017 Category: Chemistry Tags: Cross Coupling Nanoparticles Organolithium Pd Catalyzed Source Type: blogs
Direct C –H Cyanation of Arenes via Organic Photoredox Catalysis - Journal of the American Chemical Society (ACS Publications)
Disclosed here is the construction of aromatic nitriles via direct C –H functionalization using an acridinium photoredox catalyst and trimethylsilyl cyanide under an aerobic atmosphere. (Source: Organometallic Current)
Source: Organometallic Current - February 15, 2017 Category: Chemistry Tags: C-H Functionalization Cyanation Photoredox Catalysis Source Type: blogs
Convergent Route to ent-Kaurane Diterpenoids: Total Synthesis of Lungshengenin D and 1 α,6α-Diacetoxy-ent-kaura-9(11),16-dien-12,15-dione - Journal of the American Chemical Society (ACS Publications)
The Hoppe ’s homoaldol reaction of a cyclo-hexenyl carbamate with an aldehyde followed by an unprecedented BF3·OEt2 mediated intramolecular Mukaiyama –Michael-type reaction affords the tetracyclic core structure ofent-kaurane diterpenoids. (Source: Organometallic Current)
Source: Organometallic Current - February 15, 2017 Category: Chemistry Tags: Michael Reaction Mukaiyama Total synthesis Source Type: blogs
Benzyltriboronates: Building Blocks for Diastereoselective Carbon –Carbon Bond Formation - Journal of the American Chemical Society (ACS Publications)
A highly diastereoselective carbon –carbon bond-forming reaction involving the tandem coupling of benzyltriboronates, enoates, and alkyl halides is described. (Source: Organometallic Current)
Source: Organometallic Current - February 15, 2017 Category: Chemistry Tags: C-C Bond Forming Ni Catalyzed Source Type: blogs
C(sp2) –H Borylation of Fluorinated Arenes Using an Air-Stable Cobalt Precatalyst: Electronically Enhanced Site Selectivity Enables Synthetic Opportunities - Journal of the American Chemical Society (ACS Publications)
Cobalt catalysts with electronically enhanced site selectivity have been developed, as evidenced by the highortho-to-fluorine selectivity observed in the C(sp2) –H borylation of fluorinated arenes. (Source: Organometallic Current)
Source: Organometallic Current - February 15, 2017 Category: Chemistry Tags: Borylation Co catalyzed Source Type: blogs
Hydrogen Borrowing Catalysis with Secondary Alcohols: A New Route for the Generation of β-Branched Carbonyl Compounds - Journal of the American Chemical Society (ACS Publications)
A hydrogen borrowing reaction employing secondary alcohols and Ph* (Me5C6) ketones to give β-branched carbonyl products is described (21 examples). (Source: Organometallic Current)
Source: Organometallic Current - February 15, 2017 Category: Chemistry Tags: Carbonyl Ir catalyzed Source Type: blogs
Ruthenium –NHC–Diamine Catalyzed Enantioselective Hydrogenation of Isocoumarins - Journal of the American Chemical Society (ACS Publications)
A novel and practical chiral ruthenium –NHC–diamine system is disclosed for the enantioselective hydrogenation of isocoumarins, which provides a new concept to apply (chiral) NHC ligands in asymmetric catalysis. (Source: Organometallic Current)
Source: Organometallic Current - February 15, 2017 Category: Chemistry Tags: Enantioselective Heterocycles Hydrogenation NHC Ru catalyzed Source Type: blogs
Mechanistic Elucidation of Zirconium-Catalyzed Direct Amidation - Journal of the American Chemical Society (ACS Publications)
The mechanism of the zirconium-catalyzed condensation of carboxylic acids and amines for direct formation of amides was studied using kinetics, NMR spectroscopy, and DFT calculations. (Source: Organometallic Current)
Source: Organometallic Current - February 15, 2017 Category: Chemistry Tags: Amidation Zr Catalyzed Source Type: blogs
