Chiral Amino Alcohol Accelerated and Stereocontrolled Allylboration of Iminoisatins: Highly Efficient Construction of Adjacent Quaternary Stereogenic Centers
: We have developed a highly efficient asymmetric allylboration of ketimines with nonchiral γ,γ‐disubstituted allylboronic acids by using a chiral amino alcohol as the directing group, which is otherwise... (Source: Organometallic Current)
Source: Organometallic Current - March 27, 2017 Category: Chemistry Tags: Allylic Borylation organocatalysis Source Type: blogs
Synthesis of Rationally Halogenated Buckybowls by Chemoselective Aromatic C −F Bond Activation
AngewchemSynthesis of Rationally Halogenated Buckybowls by Chemoselective Aromatic C −F Bond Activation: Halogenated buckybowls or bowl ‐shaped polycyclic aromatic hydrocarbons (BS‐PAHs) are key building blocks for the “bottom‐up” synthesis of various carbon‐based nanomaterials with outstanding potential in... (Source: Organometallic Current)
Source: Organometallic Current - March 27, 2017 Category: Chemistry Tags: C-F Bond Activation PAHs Source Type: blogs
Synthesis of Complex Phenols Enabled by a Rationally Designed Hydroxide Surrogate
AngewchemSynthesis of Complex Phenols Enabled by a Rationally Designed Hydroxide Surrogate: The conversion of aryl halides to phenols under mild reaction conditions is a longstanding and formidable challenge in organic chemistry. Herein, we report the rational design of a broadly applicable Pd ‐catalyzed... (Source: Organometallic Current)
Source: Organometallic Current - March 24, 2017 Category: Chemistry Tags: Hydroxylation Pd Catalyzed Source Type: blogs
Zirconacyclopentadiene ‐Annulated Polycyclic Aromatic Hydrocarbons
AngewchemZirconacyclopentadiene ‐Annulated Polycyclic Aromatic Hydrocarbons: Syntheses of large polycyclic aromatic hydrocarbons (PAHs) and graphene nanostructures demand methods that are capable of selectively and efficiently fusing large numbers of aromatic rings, yet such methods... (Source: Organometallic Current)
Source: Organometallic Current - March 24, 2017 Category: Chemistry Tags: PAHs Polycycles Zr Catalyzed Source Type: blogs
One ‐Pot Multicomponent Synthesis of β‐Amino Amides
AngewchemOne ‐Pot Multicomponent Synthesis of β‐Amino Amides: Multicomponent reactions are excellent tools for rapid generation of small molecules with broad chemical diversity and molecular complexity. Herein, a novel one ‐pot multicomponent synthesis of β‐amino... (Source: Organometallic Current)
Source: Organometallic Current - March 23, 2017 Category: Chemistry Tags: Aminoacids Multicomponent Rxn Source Type: blogs
Copper(I)-Catalyzed Enantioselective Addition of Enynes to Ketones - Journal of the American Chemical Society (ACS Publications)
A copper(I)-catalyzed enantioselective addition of enynes to ketones was developed. The method allows facile construction of enantiomerically enriched tertiary alcohols using skipped enynes as stable hydrocarbon pronucleophiles. (Source: Organometallic Current)
Source: Organometallic Current - March 22, 2017 Category: Chemistry Tags: Cu catalyzed Enantioselective Source Type: blogs
Enantioselective Formal α‐Methylation and α‐Benzylation of Aldehydes by Means of Photo‐Organocatalysis
AngewchemEnantioselective Formal α‐Methylation and α‐Benzylation of Aldehydes by Means of Photo‐Organocatalysis: Detailed herein is the photochemical organocatalytic enantioselective α‐alkylation of aldehydes with (phenylsulfonyl)alkyl iodides. The chemistry relies on the direct photoexcitation of enamines to trigger... (Source: Organometallic Current)
Source: Organometallic Current - March 22, 2017 Category: Chemistry Tags: Enantioselective Methylation organocatalysis Photocatalysis Source Type: blogs
Catalytic Site-Selective Acylation of Carbohydrates Directed by Cation –n Interaction - Journal of the American Chemical Society (ACS Publications)
Site-selective functionalization of hydroxyl groups in carbohydrates is one of the long-standing challenges in chemistry. Using a pair of chiral catalysts, we now can differentiate the most prevalenttrans-1,2-diols in pyranoses systematically and predictably. (Source: Organometallic Current)
Source: Organometallic Current - March 21, 2017 Category: Chemistry Tags: Acylation Carbohydrates organocatalysis Source Type: blogs
Formal Allylic C(sp3) –H Bond Activation of Alkenes Triggered by a Sodium Amide - Journal of the American Chemical Society (ACS Publications)
The catalytic use of a sodium amide has been exploited for formal allylic C(sp3) –H bond activation of alkenes under mild conditions. (Source: Organometallic Current)
Source: Organometallic Current - March 21, 2017 Category: Chemistry Tags: Base catalyzed sp3 C-H Activation Source Type: blogs
Octahedral Ruthenium Complex with Exclusive Metal-Centered Chirality for Highly Effective Asymmetric Catalysis - Journal of the American Chemical Society (ACS Publications)
A novel ruthenium catalyst is introduced which contains solely achiral ligands and acquires its chirality entirely from octahedral centrochirality. The configurationally stable catalyst is demonstrated to catalyze the alkynylation of trifluoromethyl ketones with very high enantioselectivity. (Source: Organometallic Current)
Source: Organometallic Current - March 21, 2017 Category: Chemistry Tags: Alkynylation Asymmetric Ru catalyzed Source Type: blogs
Manganese ‐Catalyzed N‐Formylation of Amines by Methanol Liberating H2: A Catalytic and Mechanistic Study
AngewchemManganese ‐Catalyzed N‐Formylation of Amines by Methanol Liberating H2: A Catalytic and Mechanistic Study: The first example of a base metal (manganese) catalyzed acceptorless dehydrogenative coupling of methanol and amines to form formamides is reported herein. The novel pincer complex (iPr ‐PNHP)Mn(H)(CO)2... (Source: Organometallic Current)
Source: Organometallic Current - March 21, 2017 Category: Chemistry Tags: Formylation Mn catalyzed Source Type: blogs
Catalytic Asymmetric Diamination of Styrenes - Journal of the American Chemical Society (ACS Publications)
An enantioselective catalytic vicinal diamination of styrenes is reported, which proceeds under entirely intermolecular reaction control. (Source: Organometallic Current)
Source: Organometallic Current - March 17, 2017 Category: Chemistry Tags: Diamination Enantioselective Hypervalent Iodine Reagents Source Type: blogs
General and Efficient C –C Bond Forming Photoredox Catalysis with Semiconductor Quantum Dots - Journal of the American Chemical Society (ACS Publications)
Here we show that colloidal nanocrystal quantum dots (QDs) can serve as efficient and robust, precious-metal free, photoassisted redox catalysts. (Source: Organometallic Current)
Source: Organometallic Current - March 17, 2017 Category: Chemistry Tags: Photoredox Catalysis Source Type: blogs
An Efficient Chemoenzymatic Synthesis of Dihydroartemisinic Aldehyde
AngewchemAn Efficient Chemoenzymatic Synthesis of Dihydroartemisinic Aldehyde: Artemisinin from the plant Artemisia annua is the most potent pharmaceutical for the treatment of malaria. In the plant, the sesquiterpene cyclase amorphadiene synthase, a cytochrome ‐dependent CYP450,... (Source: Organometallic Current)
Source: Organometallic Current - March 13, 2017 Category: Chemistry Tags: Biocatalytic Enzyme catalyzed Terpenoids Source Type: blogs
Rhodium-Catalyzed Enantioselective Isomerization of Secondary Allylic Alcohols - Journal of the American Chemical Society (ACS Publications)
The first catalytic enantioselective isomerization of secondary allylic alcohols to access ketones with a α-tertiary stereocenter is presented. (Source: Organometallic Current)
Source: Organometallic Current - March 9, 2017 Category: Chemistry Tags: Allylic Enantioselective Isomerization Rh Catalyzed Source Type: blogs
