In ‐Cell Dual Drug Synthesis by Cancer‐Targeting Palladium Catalysts
AngewchemIn ‐Cell Dual Drug Synthesis by Cancer‐Targeting Palladium Catalysts: Transition metals have been successfully applied to catalyze non ‐natural chemical transformations within living cells, with the highly efficient labeling of subcellular components and the activation of prodrugs. In vivo applications, however, have been scarce, with a need for the specific cellular targeting of the active transition metals. Here, we show the design and application of cancer-targeting palladium catalysts, with their specific uptake in brain cancer (glioblastoma) cells, while maintaining their catalytic activity. (Source: Or...
Source: Organometallic Current - May 10, 2017 Category: Chemistry Tags: bioactive Pd Catalyzed Suzuki-Miyaura Coupling Source Type: blogs
Palladium ‐Catalyzed Enantioselective Redox‐Relay Heck Alkynylation of Alkenols to Access Propargylic Stereocenters
AngewchemPalladium ‐Catalyzed Enantioselective Redox‐Relay Heck Alkynylation of Alkenols to Access Propargylic Stereocenters: An enantioselective redox ‐relay Heck alkynylation of di‐ and trisubstituted alkenols to construct propargylic stereocenters is disclosed using a new pyridine oxazoline ligand. This strategy allows direct access to chiral β-alkynyl carbonyl compounds employing allylic alcohol substrates in contrast to more traditional conjugate addition methods. (Source: Organometallic Current)
Source: Organometallic Current - May 8, 2017 Category: Chemistry Tags: Alkynylation Enantioselective Pd Catalyzed Propargylic Source Type: blogs
Amide ‐Directed C−H Sodiation by a Sodium Hydride/Iodide Composite
AngewchemAmide ‐Directed C−H Sodiation by a Sodium Hydride/Iodide Composite: A new protocol for amide ‐directed ortho and lateral C−H sodiation is enabled by sodium hydride (NaH) in the presence of either sodium iodide (NaI) or lithium iodide (LiI). The transient organosodium intermediates... (Source: Organometallic Current)
Source: Organometallic Current - April 28, 2017 Category: Chemistry Tags: Metalation Sodiation Source Type: blogs
Highly Efficient Carbon Monoxide Capture by Carbanion ‐Functionalized Ionic Liquids through C‐site Interactions
AngewchemHighly Efficient Carbon Monoxide Capture by Carbanion ‐Functionalized Ionic Liquids through C‐site Interactions: A novel method for the highly efficient and reversible capture of CO in carbanion ‐functionalized ionic liquids (ILs) by a C‐site interaction is reported. Because of its supernucleophilicity, the carbanion in ILs could absorb CO efficiently. (Source: Organometallic Current)
Source: Organometallic Current - April 27, 2017 Category: Chemistry Tags: Carbon monoxide Ionic liquids Source Type: blogs
Metal ‐Free Formal Oxidative C−C Coupling by In Situ Generation of an Enolonium Species
AngewchemMetal ‐Free Formal Oxidative C−C Coupling by In Situ Generation of an Enolonium Species: Much contemporary organic synthesis relies on transformations that are driven by the intrinsic, so ‐called “natural”, polarity of chemical bonds and reactive centers. The design of unconventionally polarized synthons is a highly desirable strategy, as it generally enables unprecedented retrosynthetic disconnections for the synthesis of complex substances. Whereas the umpolung of carbonyl centers is a well-known strategy, polarity reversal at the α-position of a carbonyl group is much rarer. Herein, we report the d...
Source: Organometallic Current - April 24, 2017 Category: Chemistry Tags: Metal free Oxidative Coupling Source Type: blogs
Total Synthesis of ( −)‐Albocycline
AngewchemTotal Synthesis of ( −)‐Albocycline: The macrolactone natural product ( −)‐albocycline is a promising antibiotic candidate for the treatment of both methicillin resistant Staphylococcus aureus (MRSA) and vancomycin‐resistant strains. Herein... (Source: Organometallic Current)
Source: Organometallic Current - April 21, 2017 Category: Chemistry Tags: Total synthesis Source Type: blogs
Permeable Self-Assembled Molecular Containers for Catalyst Isolation Enabling Two-Step Cascade Reactions
JacsPermeable Self-Assembled Molecular Containers for Catalyst Isolation Enabling Two-Step Cascade Reactions: Permeable Self-Assembled Molecular Containers for Catalyst Isolation Enabling Two-Step Cascade ReactionsEstablishment of a general one-pot cascade reaction protocol would dramatically reduce the effort of multistep organic synthesis. We demonstrate that the unique structure of M12L24 self-assembled complexes gives them the potential to serve as catalyst carriers for enabling continuous chemical transformations. (Source: Organometallic Current)
Source: Organometallic Current - April 21, 2017 Category: Chemistry Tags: Allylic Cascade Diels Alder Source Type: blogs
Synthesis of Chiral Tertiary Boronic Esters: Phosphonate-Directed Catalytic Asymmetric Hydroboration of Trisubstituted Alkenes Aminophosphonic and aminophosphinic acids: chemistry and biological activity
JacsSynthesis of Chiral Tertiary Boronic Esters: Phosphonate-Directed Catalytic Asymmetric Hydroboration of Trisubstituted Alkenes Aminophosphonic and aminophosphinic acids: chemistry and biological activity: Synthesis of Chiral Tertiary Boronic Esters: Phosphonate-Directed Catalytic Asymmetric Hydroboration of Trisubstituted Alkenes Aminophosphonic and aminophosphinic acids: chemistry and biological activity (Source: Organometallic Current)
Source: Organometallic Current - April 21, 2017 Category: Chemistry Tags: Asymmetric Hydroboration Rh Catalyzed Source Type: blogs
Radical Borylation/Cyclization Cascade of 1,6-Enynes for the Synthesis of Boron-Handled Hetero- and Carbocycles - Journal of the American Chemical Society (ACS Publications)
A synthetic method to construct boron-handled cyclic molecules was developed based on a radical borylation/cyclization cascade of 1,6-enynes. (Source: Organometallic Current)
Source: Organometallic Current - April 20, 2017 Category: Chemistry Tags: Borylation Heterocycles Source Type: blogs
A Concise, Efficient and Scalable Total Synthesis of Thapsigargin and Nortrilobolide from (R)-( −)-Carvone - Journal of the American Chemical Society (ACS Publications)
A concise, efficient and scalable synthesis of thapsigargin and nortrilobolide from commercially available (R)-( −)-carvone was developed. Our synthetic strategy is inspired by nature’s carbon–carbon bond formation sequence, which facilitates the construction of a highly functionalized sesquiterpene lactone skeleton in five stepsvia an enantioselective ketone alkylation and a diastereoselective pinacol cyclization. (Source: Organometallic Current)
Source: Organometallic Current - April 20, 2017 Category: Chemistry Tags: Alkylation Enantioselective Pinacol rearrangement Total synthesis Source Type: blogs
Nickel-Catalyzed Direct Synthesis of Aryl Olefins from Ketones and Organoboron Reagents under Neutral Conditions - Journal of the American Chemical Society (ACS Publications)
Nickel-catalyzed addition of arylboron reagents to ketones results in aryl olefins directly. The neutral condition allows acidic protons of alcohols, phenols, and malonates to be present, and fragile structures are also tolerated. (Source: Organometallic Current)
Source: Organometallic Current - April 19, 2017 Category: Chemistry Tags: Ni Catalyzed Olefination Source Type: blogs
Remarkably Facile Borane-Promoted, Rhodium-Catalyzed Asymmetric Hydrogenation of Tri- and Tetrasubstituted Alkenes - Journal of the American Chemical Society (ACS Publications)
AngewchemRemarkably Facile Borane-Promoted, Rhodium-Catalyzed Asymmetric Hydrogenation of Tri- and Tetrasubstituted Alkenes - Journal of the American Chemical Society (ACS Publications)Oxime-directed catalytic asymmetric hydroboration is diverted to catalytic asymmetric hydrogenation (CAH) upon the addition of a proton source, such as MeOH, or by running the reaction under a hydrogen atmosphere. A borane (e.g., pinacolborane) is required to promote CAH. (Source: Organometallic Current)
Source: Organometallic Current - April 19, 2017 Category: Chemistry Tags: Asymmetric Hydrogenation B catalyzed Mo Catalyzed Rh Catalyzed Source Type: blogs
Copper-Catalyzed Dicarbofunctionalization of Unactivated Olefins by Tandem Cyclization/Cross-Coupling - Journal of the American Chemical Society (ACS Publications)
We present a strategy that difunctionalizes unactivated olefins in 1,2-positions with two carbon-based entities. (Source: Organometallic Current)
Source: Organometallic Current - April 19, 2017 Category: Chemistry Tags: Cross Coupling Cu catalyzed Cyclization Difunctionalization Source Type: blogs
Cu/Pd Synergistic Dual Catalysis: Asymmetric α‐Allylation of an α‐CF3 Amide
AngewchemCu/Pd Synergistic Dual Catalysis: Asymmetric α‐Allylation of an α‐CF3 Amide: Despite the burgeoning demand for fluorine ‐containing chemical entities, the construction of CF3‐containing stereogenic centers has remained elusive. Herein, we report the strategic merger of CuI/base‐catalyzed... (Source: Organometallic Current)
Source: Organometallic Current - April 19, 2017 Category: Chemistry Tags: Allenylation Asymmetric Cu catalyzed Dual Catalysis Pd Catalyzed Source Type: blogs
Transition metal –catalyzed alkyl-alkyl bond formation: Another dimension in cross-coupling chemistry
ByJunwon Choi,Gregory C. FuScience 14 Apr 2017: Vol. 356, Issue 6334, eaaf7230 DOI: 10.1126/science.aaf7230Choi and Fu review recent developments in forming bonds between the more abundant alkyl carbon centers that underlie diverse molecules with complex three-dimensional structures. Nickel catalysis in particular has emerged as a powerful method to access individual mirror-image isomers selectively and thereby tune the biological properties of the targeted products. (Source: Organometallic Current)
Source: Organometallic Current - April 14, 2017 Category: Chemistry Tags: Reviews Source Type: blogs
