A Bioinspired Nitrone Precursor to a Stabilized Nitroxide Radical
Free Radic Biol Med. 2021 Mar 30:S0891-5849(21)00190-8. doi: 10.1016/j.freeradbiomed.2021.03.030. Online ahead of print.ABSTRACTNitrones derived from natural antioxidants are emerging as highly specific therapeutics against various human diseases, including stroke, neurodegenerative pathologies, and cancer. However, the development of useful pseudo-natural nitrones requires the judicious choice of a secondary metabolite as the precursor. Betalains are nitrogen-containing natural pigments that exhibit marked antioxidant capacity and pharmacological properties and, hence, are ideal candidates for designing multifunctional ni...
Source: Free Radical Biology and Medicine - April 2, 2021 Category: Biology Authors: Amanda Capistrano Pinheiro Rodrigo Boni Fazzi Larissa Cerrato Esteves Caroline Oliveira Machado Felipe Augusto D örr Ernani Pinto Yocefu Hattori Jacinto Sa Ana Maria da Costa Ferreira Erick Leite Bastos Source Type: research
A Bioinspired Nitrone Precursor to a Stabilized Nitroxide Radical
Free Radic Biol Med. 2021 Mar 30:S0891-5849(21)00190-8. doi: 10.1016/j.freeradbiomed.2021.03.030. Online ahead of print.ABSTRACTNitrones derived from natural antioxidants are emerging as highly specific therapeutics against various human diseases, including stroke, neurodegenerative pathologies, and cancer. However, the development of useful pseudo-natural nitrones requires the judicious choice of a secondary metabolite as the precursor. Betalains are nitrogen-containing natural pigments that exhibit marked antioxidant capacity and pharmacological properties and, hence, are ideal candidates for designing multifunctional ni...
Source: Free Radical Biology and Medicine - April 2, 2021 Category: Biology Authors: Amanda Capistrano Pinheiro Rodrigo Boni Fazzi Larissa Cerrato Esteves Caroline Oliveira Machado Felipe Augusto D örr Ernani Pinto Yocefu Hattori Jacinto Sa Ana Maria da Costa Ferreira Erick Leite Bastos Source Type: research
