Origanum vulgare ethanolic extracts as a promising source of compounds with antimicrobial, anti-biofilm, and anti-virulence activity against dental plaque bacteria
Dental caries and periodontal diseases remain a challenge for oral health, especially given the lack of effective and safe treatment options that are currently available. Against the backdrop of an ongoing antimicrobial resistance crisis, a renewed interest in traditional medicinal plants as a potential source of new bioactive compounds has surfaced. In this context, we systematically screened the antimicrobial and anti-biofilm activities of both ethanolic and aqueous extracts of nine Algerian medicinal plants (Artemisia herba alba, Centaurium erythraea, Juglans regia, Laurus nobilis, Matricaria recutita, Mentha pulegium, ...
Source: Frontiers in Microbiology - November 2, 2022 Category: Microbiology Source Type: research
Cinnamtannin B-1 inhibits the progression of osteosarcoma by regulating the miR-1281/PPIF axis
In this study, CTB-1 was found to inhibit the proliferation of OS cancer cells, with the dose of CTB-1 positively correlated to the survival rate of HOS and MG-63 cells. Recently, microRNAs (miRNAs) were also reported to play an important role in tumor proliferation. Hence, we performed the miRNA sequencing analysis after CTB-1 treatment to identify miRNA levels in HOS cells and found that the expression of mir-1281 was significantly upregulated. According to the functional analysis, CTB-1 inhibited the growth and migration of OS by upregulating the expression of miR-1281. Additionally, miR-1281 acted as a sponge for Pepti...
Source: Biological and Pharmaceutical Bulletin - October 23, 2022 Category: Drugs & Pharmacology Authors: Jun Jia Jiaojiao Xia Weifeng Liu Fengqin Tao Jun Xiao Source Type: research
Cinnamtannin B-1 inhibits the progression of osteosarcoma by regulating the miR-1281/PPIF axis
In this study, CTB-1 was found to inhibit the proliferation of OS cancer cells, with the dose of CTB-1 positively correlated to the survival rate of HOS and MG-63 cells. Recently, microRNAs (miRNAs) were also reported to play an important role in tumor proliferation. Hence, we performed the miRNA sequencing analysis after CTB-1 treatment to identify miRNA levels in HOS cells and found that the expression of mir-1281 was significantly upregulated. According to the functional analysis, CTB-1 inhibited the growth and migration of OS by upregulating the expression of miR-1281. Additionally, miR-1281 acted as a sponge for Pepti...
Source: Biological and Pharmaceutical Bulletin - October 23, 2022 Category: Drugs & Pharmacology Authors: Jun Jia Jiaojiao Xia Weifeng Liu Fengqin Tao Jun Xiao Source Type: research
Cinnamtannin B-1 inhibits the progression of osteosarcoma by regulating the miR-1281/PPIF axis
In this study, CTB-1 was found to inhibit the proliferation of OS cancer cells, with the dose of CTB-1 positively correlated to the survival rate of HOS and MG-63 cells. Recently, microRNAs (miRNAs) were also reported to play an important role in tumor proliferation. Hence, we performed the miRNA sequencing analysis after CTB-1 treatment to identify miRNA levels in HOS cells and found that the expression of mir-1281 was significantly upregulated. According to the functional analysis, CTB-1 inhibited the growth and migration of OS by upregulating the expression of miR-1281. Additionally, miR-1281 acted as a sponge for Pepti...
Source: Biological and Pharmaceutical Bulletin - October 23, 2022 Category: Drugs & Pharmacology Authors: Jun Jia Jiaojiao Xia Weifeng Liu Fengqin Tao Jun Xiao Source Type: research
Antibacterial activity of essential oils extracted from the unique Chinese spices cassia bark, bay fruits and cloves
In this study, three spices with unique Chinese characteristics widely used were selected: cassia bark (bark of Cinnamomum camphora Presl), bay fruits (Laurus nobilis), and cloves (Syzygiumaromaticum). The main components and antibacterial ability of these three spices were analyzed by simulated extraction method. Through headspace solid-phase microextraction (HS-SPME) and gas chromatography-mass spectrometry (GC-MS) analysis, it was determined that the main active compounds in the essential oils of cassia bark, bay fruits and cloves were cinnamaldehyde (78.11%), cinnamaldehyde (61.78%) and eugenol (75.23%), respectively. ...
Source: Archives of Microbiology - October 18, 2022 Category: Microbiology Authors: Chunling Jiang Jiaju Hong Jing Meng Jie Ou Qingchao Xie Yingjie Pan Yong Zhao Haiquan Liu Source Type: research
