William F. C. Rigby, MD - Improving Outcomes for Patients With Refractory Rheumatoid Arthritis: The Role of JAK Inhibitors
Improving Outcomes for Patients With Refractory Rheumatoid Arthritis: The Role of JAK Inhibitors (Source: Peerview CME/CE Video Podcast - Internal Medicine International)
Source: Peerview CME/CE Video Podcast - Internal Medicine International - October 12, 2018 Category: Internal Medicine Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video
Pathways to Prevention Workshop Appropriate Use of Drug Therapies for Osteoporotic Fracture Prevention (Day 2)
About Osteoporotic Fractures
More than 10 million people in the United States have osteoporosis, a skeletal disorder that causes bones to become weak and fragile as a result of low bone mass. The condition makes people more susceptible to fractures, which can impair their ability to live independently and even threaten their lives. The social and economic burden of osteoporotic fractures is substantial. Reducing osteoporosis prevalence and hip fracture incidence are among the major objectives of Healthy People 2020, the U.S. Department of Health& Human Services ’ national health promotion and disease prevention initiativ...
Source: Videocast - All Events - July 18, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Pathways to Prevention Workshop Appropriate Use of Drug Therapies for Osteoporotic Fracture Prevention (Day 1)
About Osteoporotic Fractures
More than 10 million people in the United States have osteoporosis, a skeletal disorder that causes bones to become weak and fragile as a result of low bone mass. The condition makes people more susceptible to fractures, which can impair their ability to live independently and even threaten their lives. The social and economic burden of osteoporotic fractures is substantial. Reducing osteoporosis prevalence and hip fracture incidence are among the major objectives of Healthy People 2020, the U.S. Department of Health& Human Services ’ national health promotion and disease prevention initiativ...
Source: Videocast - All Events - July 18, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
2018 Lipsett Lecture: " Oncofertility: From Bench to Bedside to Babies "
The Lipsett Lecture is an annual lecture held by NICHD to honor Dr. Mortimer B. Lipsett, Director of the National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health (NIH), who died of cancer on November 10, 1985 at the Clinical Center. This year's speaker will be Dr. Teresa K. Woodruff, Dean and Associate Provost for Graduate Education in The Graduate School at Northwestern University and Thomas J. Watkins Professor of Obstetrics& Gynecology, the Vice Chair for Research and the Chief of the Division of Reproductive Science in Medicine in the Department of Obstetrics and Gynec...
Source: Videocast - All Events - June 12, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
B cells in Autoimmune diseases: Focus on Sj ö gren's Syndrome
NIDCR Clinical Research Fellowship Grand Rounds
B cells play a complex role in the development of systemic autoimmune diseases, especially in primary Sj ö gren's syndrome, a progressive condition that damages saliva and tear glands and leads to dry mouth, dry eyes, and other symptoms. Dr. Jacques-Olivier Pers will outline growing evidence that regulatory B lymphocytes (Breg) may blunt the pathogenesis of systemic autoimmune disease, and thus may be potential targets for treatment. Studies of distinct B cell subsets that play differing roles in autoimmune diseases are providing new insights into Breg development and immune...
Source: Videocast - All Events - April 11, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Effectors versus Protectors: How Anti-inflammatory Tissue Macrophages Maintain Tissue Homeostasis
Immunonology IG Seminar
Dr. Stefan Uderhardt is a post-doctoral fellow in Dr. Ronald Germain's group within the Laboratory of Systems Biology (LSB), NIAID. Stefan received his medical degree (Dr. med.) from the University of Erlangen-N ü rnberg, Germany in 2011. Early during medical school he developed a passion for immunological research, and thus spent most his spare time working on an experimental thesis on osteoimmunology in the lab of Georg Schett and Gerhard Kr ö nke, investigating the mechanisms of bone loss during inflammatory arthritis. He then started a residency in rheumatology and clinical immunology at the U...
Source: Videocast - All Events - January 19, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
A Bacterial Cause of Rheumatoid Arthritis
NIDCR Clinical Research Fellowship Grand Rounds
Understanding the mechanisms which initiate immune responses to autoantigens is of high priority. Significant data implicates mucosal surfaces, specifically the periodontium, the gut, and the lungs, as sites of disease initiation in rheumatoid arthritis (RA), an autoimmune disease characterized by autoantibodies to citrullinated proteins. In recent studies, we identified Aggregatibacter actinomycetemcomitans (Aa), a pathogen associated with chronic and aggressive periodontitis, as a candidate bacterial trigger of autoimmunity in RA. Aa secretes a toxin, leukotoxin A (LtxA), w...
Source: Videocast - All Events - November 8, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
William F.C. Rigby, MD - JAK Inhibitors in Rheumatoid Arthritis: Aligning Pathophysiology, Treatment Advances, and Patient Preference Into a Personalized Approach to Care for Improved Outcomes
JAK Inhibitors in Rheumatoid Arthritis: Aligning Pathophysiology, Treatment Advances, and Patient Preference Into a Personalized Approach to Care for Improved Outcomes (Source: Peerview CME/CE Video Podcast - Internal Medicine International)
Source: Peerview CME/CE Video Podcast - Internal Medicine International - October 11, 2017 Category: Internal Medicine Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video
The development and Function of Regulatory T cells
Immunology Interest Group Seminar Series
Dr. Chen ’ s research focuses on elucidating mechanisms of T-cell immunity and tolerance and manipulating T-cell immunity versus tolerance in animal models to understand the pathogenesis of and develop immunotherapy for autoimmunity, cancer and infectious diseases. Among his many scientific contributions to biomedical research, Dr. Chen is the first to discover that TGF-beta induces Foxp3 gene in naive CD4+ T cells and converts them into regulatory T cells (iTregs, pTregs). The paper describing this finding has been cited for more than 4000 times. He has also demonstrated that TGF...
Source: Videocast - All Events - September 25, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Alan J. Kivitz, MD, CPI - Addressing Unmet Needs in Rheumatoid Arthritis Through Novel Treatment Options and Enhanced Physician –Patient Collaboration
Addressing Unmet Needs in Rheumatoid Arthritis Through Novel Treatment Options and Enhanced Physician–Patient Collaboration (Source: Peerview CME/CE Video Podcast - Internal Medicine International)
Source: Peerview CME/CE Video Podcast - Internal Medicine International - September 6, 2017 Category: Internal Medicine Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video
Philip J. Mease, MD, MACR - Optimizing Outcomes Throughout the Journey of Patients With Psoriatic Arthritis: A Closer Look at the Importance of Early Diagnosis and Role of New Treatment Options
Optimizing Outcomes Throughout the Journey of Patients With Psoriatic Arthritis: A Closer Look at the Importance of Early Diagnosis and Role of New Treatment Options (Source: Peerview CME/CE Video Podcast - Internal Medicine International)
Source: Peerview CME/CE Video Podcast - Internal Medicine International - August 7, 2017 Category: Internal Medicine Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video
Law of STAT fives, root orchestrators of lymphocyte homeostasis and function
Immunology Interest Group Seminar Series
The transcription factor STAT5 is fundamental to the mammalian immune system. Operating downstream of cytokines and growth factors, it impacts all aspects of lymphocyte biology, from general cellular processes like proliferation and apoptosis, to specialized immunological programs like effector and regulatory T cell differentiation. Genetic studies in humans underscore its widespread influence as mutations of STAT5 or upstream activators manifest varied Alejandro Villarino, NIAMS, NIHimmunological phenotypes including immunodeficiency, autoimmunity and hematological malignancies. Mo...
Source: Videocast - All Events - June 20, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
