A large, observational study of common gout treatment allopurinol shows less than half of patients reach recommended treatment goal
(Edelman Public Relations) AstraZeneca and Ardea Biosciences today presented results from a large study of allopurinol, a treatment commonly used to lower uric acid in patients with gout. The LASSO (Long-term Allopurinol Safety Study evaluating Outcomes in gout patients) study was a multinational, six-month, open, prospective observational study involving 1,735 patients with gout and was designed to evaluate the safety and efficacy of medically appropriate doses of allopurinol. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 28, 2013 Category: Global & Universal Source Type: news
Gout: No Help From Vitamin C Gout: No Help From Vitamin C
In patients with gout, vitamin C supplementation at 500 mg/day, either alone or with allopurinol, did not reduce uric acid levels enough to be clinically significant. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 16, 2013 Category: Consumer Health News Tags: Rheumatology News Source Type: news
Vitamin C No Help in Gout (CME/CE)
(MedPage Today) -- Vitamin C supplements didn't lower uric acid levels in patients with gout when given either alone or in combination with allopurinol, an open-label pilot study showed. (Source: MedPage Today State Required CME)
Source: MedPage Today State Required CME - May 16, 2013 Category: Consumer Health News Source Type: news
Vitamin C Does Not Lower Uric Acid Levels In Gout Patients
Despite previous studies touting its benefit in moderating gout risk, new research reveals that vitamin C, also known ascorbic acid, does not reduce uric acid (urate) levels to a clinically significant degree in patients with established gout. Vitamin C supplementation, alone or in combination with allopurinol, appears to have a weak effect on lowering uric acid levels in gout patients according to the results published in the American College of Rheumatology (ACR) journal, Arthritis & Rheumatism... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 16, 2013 Category: Consumer Health News Tags: Gout Source Type: news
Vitamin C does not lower uric acid levels in gout patients
(Wiley) Despite previous studies touting its benefit in moderating gout risk, new research reveals that vitamin C, also known ascorbic acid, does not reduce uric acid (urate) levels to a clinically significant degree in patients with established gout. Vitamin C supplementation, alone or in combination with allopurinol, appears to have a weak effect on lowering uric acid levels in gout patients according to the results published in the American College of Rheumatology journal, Arthritis & Rheumatism. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 16, 2013 Category: Global & Universal Source Type: news
Allopurinol: Severe Cutaneous Reactions Rare but Serious Allopurinol: Severe Cutaneous Reactions Rare but Serious
Severe cutaneous reactions requiring hospitalization are rare but occurred 10 times more often among patients beginning allopurinol treatment, and most often in the first 180 days of use. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 3, 2013 Category: Consumer Health News Tags: Rheumatology News Source Type: news
RCT: High-dose allopurinol reduces left ventricular mass in patients with ischaemic heart disease
Source: J Am Coll Cardiol
Area: News
Left ventricular hypertrophy (LVH) is common in patients with IHD including normotensive patients. Allopurinol, a xanthine oxidase inhibitor, has been shown to reduce LV afterload in IHD and may therefore also regress LVH. This randomised placebo-controlled study sought to ascertain if high-dose allopurinol regresses left ventricular mass (LVM) in patients with ischemic heart disease (IHD). Sixty six patients with IHD and LVH were randomised to either 600mg allopurinol daily or placebo for 9 months. The primary outcome measure was change in LVM, assessed by cardiac magnetic resonance i...
Source: NeLM - Cardiovascular Medicine - March 8, 2013 Category: Cardiology Source Type: news
