Clinical Efficacy and Safety of Paclitaxel Polymeric Micelles for Injection in the Treatment of Patients With Taxans-resistant Pancreatic Adenocarcinoma, Cholangiocarcinoma, Lung Cancer, Gastric Cancer, Esophageal Carcinoma, or Breast Cancer
Conditions: Pancreatic Adenocarcinoma; Cholangiocarcinoma; Lung Cancer; Stomach Cancer; Esophageal Carcinoma; Breast Cancer Interventions: Drug: Paclitaxel Polymeric Micelles for Injection Sponsors: Liu Huang Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 10, 2024 Category: Research Source Type: clinical trials
Synergistic Immunomodulatory Effect of Synbiotics Pre and Postoperative Resection of Pancreatic Ductal Adenocarcinoma
Conditions: Pancreatic Ductal Adenocarcinoma Interventions: Dietary Supplement: probiotic agent 25 Billion CFU (Nowfoods, USA) , ). Inulin capsules 1000mg Herbamama USA Sponsors: Theodor Bilharz Research Institute Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 10, 2024 Category: Research Source Type: clinical trials
AK104 in Combination With AK112 Plus Chemotherapy(SOX/XELOX) as First-line Treatment for Advanced G/GEJ Cancer
Conditions: Gastric Adenocarcinoma; Gastroesophageal Junction Adenocarcinoma Interventions: Biological: Cadonilimab; Biological: Ivonescimab; Drug: XELOX; Drug: SOX Sponsors: Harbin Medical University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 9, 2024 Category: Research Source Type: clinical trials
Investigate the Efficacy of Chemotherapy in Patients With Positive ctDNA After Surgery and Adjuvant Chemotherapy for a Stage III Colorectal Cancer
Conditions: Colon or Upper Rectum Adenocarcinoma Interventions: Drug: " FOLFIRI " cures; Drug: Trifluridine cures; Biological: BIOLOGICAL ASSESSMENT; Other: Questionnaires; Other: Thoracic-abdomino-pelvic scan or MRI Sponsors: Centre Hospitalier Universitaire Dijon Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 9, 2024 Category: Research Source Type: clinical trials
Clinical Study of Short-course Radiotherapy Followed by Fruquintinib Plus Sintilimab vs Bevacizumab Plus Capecitabine as First Line Treatment in Advanced mCRC
Conditions: CRC; Metastatic Colorectal Cancer; Metastatic Colorectal Adenocarcinoma Interventions: Drug: Experimental; Drug: Active Comparator Sponsors: Zhejiang Cancer Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 8, 2024 Category: Research Source Type: clinical trials
Adebrelimab Combined With SOX Regimen in Preoperative Neoadjuvant Transformation Therapy for Locally Advanced Gastric Adenocarcinoma
Conditions: Locally Advanced Gastric Adenocarcinoma Interventions: Drug: adebrelimab, S-1 and oxaliplatin; Drug: S-1 and oxaliplatin Sponsors: Yang Jianjun, PhD Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 5, 2024 Category: Research Source Type: clinical trials
Prostatic Size Reduction Following of Leuprorelin Acetate
Conditions: Prostate Cancer Adenocarcinoma; Prostate Adenocarcinoma Interventions: Other: ACETATE LEUPRELINE Sponsors: Consorci Sanitari de Terrassa Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 28, 2023 Category: Research Source Type: clinical trials
Head-to-head Comparison of Positron Nuclide Radio-labeled FAPI and 18F-FDG PET/CT in Patients With Malignant Tumors
Conditions: Renal Cell Carcinoma; Gastric Cancer; Hepatocellular Carcinoma; Signet Ring Cell Carcinoma; Mucinous Adenocarcinoma; Colorectal Cancer Interventions: Diagnostic Test: FAPI PET/CT Sponsors: Guangdong Provincial People ' s Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 27, 2023 Category: Research Source Type: clinical trials
Pathogenic Variants in Genes Associated With Lung Adenocarcinoma
Conditions: Lung Adenocarcinoma Sponsors: Oscar Gerardo Arrieta Rodr íguez Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 25, 2023 Category: Research Source Type: clinical trials
ProAgio in Pancreatic Ductal Adenocarcinoma (PDAC)
Conditions: Pancreatic Ductal Carcinoma Interventions: Drug: ProAgio Dose Levels (DL) 1,2,3,4; Drug: Gemcitabine, nab paclitaxel Sponsors: ProDa BioTech, LLC; University of Alabama at Birmingham; Georgia State University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 25, 2023 Category: Research Source Type: clinical trials
M108 Plus CAPOX Versus Placebo Plus CAPOX as First-line Treatment for Claudin (CLDN) 18.2-Positive, HER2-Negative, PD-L1 CPS < 5, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma.
Conditions: Locally Advanced Unresectable or Metastatic Gastric Cancer; Locally Advanced Unresectable or Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma Interventions: Drug: M108 monoclonal antibody; Drug: Placebo; Drug: Oxaliplatin; Drug: Capecitabine Sponsors: FutureGen Biopharmaceutical (Beijing) Co., Ltd Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 20, 2023 Category: Research Source Type: clinical trials
Enasidenib in IDH2-Mutated Malignant Sinonasal and Skull Base Tumors
Conditions: Metastatic Chondrosarcoma; Locally Advanced Chondrosarcoma; Metastatic Sinonasal Adenocarcinoma; Locally Advanced Sinonasal Adenocarcinoma; Metastatic Large-cell Neuroendocrine Carcinoma; Locally Advanced Large-cell Neuroendocrine Carcinoma; Metastatic Olfactory Neuroblastoma; Locally Advanced Olfactory Neuroblastoma; Metastatic Sinonasal Undifferentiated Carcinoma; Locally Advanced Sinonasal Undifferentiated Carcinoma Interventions: Drug: Enasidenib Sponsors: National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 20, 2023 Category: Research Source Type: clinical trials
Induction of double-strand breaks with the non-steroidal androgen receptor ligand flutamide in patients on androgen suppression: a study protocol for a randomized, double-blind prospective trial
This study will confirm in humans the pharmacodynamic effect of AR ligands to induce transient double-strand breaks when administered in the context of androgen deprivation as a novel therapy for prostate cancer. The findings of this study will permit the development of a larger trial evaluating flutamide pulsed-dose sequencing in association with fractionated external beam RT (+/ − brachytherapy). The study is ongoing, and preliminary data collection and recruitment are underway; analysis has yet to be performed.Trial registrationClinicalTrials.gov NCT03507608. Prospectively registered on 25 April 2018. (Source: Trials)
Source: Trials - December 16, 2023 Category: Research Source Type: clinical trials
Abiraterone and Prednisone or Darolutamide for the Treatment of Advanced Prostate Cancer
Conditions: Advanced Prostate Adenocarcinoma; Stage III Prostate Cancer AJCC v8; Stage IV Prostate Cancer AJCC v8 Interventions: Drug: Abiraterone; Procedure: Biospecimen Collection; Drug: Darolutamide; Drug: Prednisone Sponsors: Mamta Parikh; National Cancer Institute (NCI) Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 15, 2023 Category: Research Source Type: clinical trials
caBozantinib in Pre-treated pAtients With Metastatic COlorectal Cancer.
Conditions: Refractory Colorectal Adenocarcinoma Interventions: Drug: Cabozantinib Sponsors: University of Campania " Luigi Vanvitelli " Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 15, 2023 Category: Research Source Type: clinical trials
