Fight Aging! Newsletter, December 21st 2020
In this study, we have found that administration of a specific Sgk1 inhibitor significantly reduces the dysregulated form of tau protein that is a pathological hallmark of AD, restores prefrontal cortical synaptic function, and mitigates memory deficits in an AD model. These results have identified Sgk1 as a potential key target for therapeutic intervention of AD, which may have specific and precise effects."
Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer's disease
Epigenetic aberration is implicated in aging and neurodegeneration. Using p...
Source: Fight Aging! - December 20, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Immune Aging is the Foundation of Frailty
Here find a perspective on the great importance of a functional immune system to health in later life. Many of the declines of aging appear strongly influenced, at the very least, by the progressive disarray of the immune system. It becomes less competent in destroying pathogens and malfunctioning cells, but at the same time ever more active in response to the molecular damage and cellular dysfunction accompanying aging. That inappropriate activity takes the form of chronic inflammation that disrupts tissue function and accelerates the onset and progression of all of the common age-related conditions.
The interrel...
Source: Fight Aging! - December 15, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 5th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 4, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Research Agenda for Aging in China
Today's review paper is a look at views on aging on the other side of the world, a counterpoint to commentaries from US and European sources. It is interesting to compare the intersection between science and policy in different regions of the world, when it comes to perspectives on degenerative aging, the enormous costs of age-related disease, and what is to be done about it. It is only comparatively recently that scientific advances have offered the potential for aging to become anything other than an inevitable, enormous cost to be suffered. Governments with entrenched and growing entitlement programs (such as the US Soc...
Source: Fight Aging! - September 30, 2020 Category: Research Authors: Reason Tags: Politics and Legislation Source Type: blogs
Fight Aging! Newsletter, July 20th 2020
This study was the first to demonstrate a causal relationship between glial senescence and neurodegeneration. In this study, accumulations of senescent astrocytes and microglia were found in tau-associated neurodegenerative disease model mice. Elimination of these senescent cells via a genetic approach can reduce tau deposition and prevent the degeneration of cortical and hippocampal neurons.
Most recently, it was shown that clearance of senescent oligodendrocyte progenitor cells in AD model mice with senolytic agents could lessen the Aβ plaque load, reduce neuroinflammation, and ameliorate cognitive deficits. This...
Source: Fight Aging! - July 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Repetitive Element Activity is Reduced in Mice Subject to Interventions that Modestly Slow Aging
Today's open access paper is a companion piece to a recent discussion of repetitive element activity as a potential biomarker of biological aging. In today's paper, the authors note that a number of interventions that modestly slow aging in mice also reduce the activity of repetitive elements in the genome. Many forms of repetitive element are the remnants of ancient viruses, sequences that are capable of copying themselves into new locations in the genome, but are normally suppressed. A fair amount of attention has been given to retrotransposons, one category of repetitive elements, in the context of aging in recent years...
Source: Fight Aging! - July 14, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Insulin in the Human Body
You're reading Insulin in the Human Body, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles.
What is insulin?
To do the tasks, the body needs energy and sugar can be considered a good source of energy to be obtained from inside. As a matter of fact, sugar cannot be directly reached to most of your cells. Thus, there are cells emitted from the pancreas, which will release the sugar in the human body which is termed as insulin.
Insulin is a hormone that is secreted by the pancreas that is responsible for the regulation ...
Source: PickTheBrain | Motivation and Self Improvement - August 2, 2019 Category: Consumer Health News Authors: Chandan Singh Tags: health and fitness Source Type: blogs
Fight Aging! Newsletter, April 15th 2019
In this study, we found that senescent chondrocytes isolated from OA patients secrete more EVs compared with nonsenescent chondrocytes. These EVs inhibit cartilage ECM deposition by healthy chondrocytes and can induce a senescent state in nearby cells. We profiled the miR and protein content of EVs isolated from the synovial fluid of OA joints from mice with SnCs. After treatment with a molecule to remove SnCs, termed a senolytic, the composition of EV-associated miR and protein was markedly altered. The senolytic reduced OA development and enhanced chondrogenesis, and these were attributable to several specific differenti...
Source: Fight Aging! - April 14, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Interventions Testing Program Finds Glycine Supplementation has a Tiny Effect on Mouse Life Span
The NIA Interventions Testing Program (ITP) is a very conservative organization. The organizers take compounds that cannot possibly do more than slightly slow aging, largely those that upregulate stress response mechanisms in a similar way to calorie restriction, and rigorously test them in large mouse studies. The results are of the best quality, and tend to demonstrate that most earlier, less rigorous studies overestimated the effects of compounds on life span. This is an expensive business, but I would say one of dubious practical value.
The practice of calorie restriction shows us the likely bounds of the possib...
Source: Fight Aging! - April 10, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
ZERO tolerance for hypoglycemia
As more and more type 2 diabetics discover the Wheat Belly and other low-carb lifestyles, they are also discovering how rapidly and easily blood sugars drop.
As diabetics become less diabetic–a process that can occur VERY quickly, often within 24 hours of removing all wheat/grains from their diet–but they are taking insulin or certain diabetes drugs, there is potential for hypoglycemia or low blood sugar. Low blood sugar from diabetes drugs can be dangerous and should be avoided at all costs. (Imagine if a non-diabetic started administering insulin or blood sugar-reducing drugs–it would result in life-threate...
Source: Wheat Belly Blog - December 23, 2018 Category: Cardiology Authors: Dr. Davis Tags: News & Updates blood sugar diabetes undoctored wheat belly Source Type: blogs
A Call to Test Combinations of Drugs Shown to Slow Aging in Animal Studies
I expect that little progress towards sizable human life extension will be achieved in the next few decades via pharmaceuticals that slow aging through triggering various stress response mechanisms. This includes calorie restriction mimetics, autophagy enhancers, exercise mimetics, and the like. It may well be the case that researchers come up with a few drugs that, if taken regularly for decades, reliably add a few years to life expectancy and improve health in old age to a degree that is in the same ballpark as the present results of exercise or eating a better diet. Is that worth billions in funding and decades of dedic...
Source: Fight Aging! - January 4, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Glucose Metabolism and Acarbose in Aging
A large proportion of present research into the mechanisms of aging seeks the underlying reasons that link good lifestyle choices with greater life expectancy and lower incidence of age-related disease. When considered in the grand scheme of things, looking towards a future of rejuvenation and life spans ultimately extended by centuries and more, this is a fairly parochial concern: natural variations in longevity will cease to be important shortly after the clinical availability of the first generation of rejuvenation therapies based on the SENS research portfolio. Nonetheless, most investigative research is focused on wha...
Source: Fight Aging! - January 6, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Summary of the NIA Interventions Testing Program
The NIA Interventions Testing Program (ITP) is a fairly old-school effort to rigorously test all the plausible claims of modestly slowed aging in mice via pharmaceuticals, dietary supplements, and environmental factors like calorie restriction. For those of us more interested in outright rejuvenation through damage repair after the SENS model, rather than merely slowing aging a little, I think there still a number of things worth learning from the ITP results to date. For example, firstly, that almost all claims of slowed aging in mice due to supplements and drugs made in past years were artifacts or otherwise erroneous re...
Source: Fight Aging! - December 13, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Marmosets in Aging Research
The use of animals in the study of aging has always meant striking a balance between species life span and distance from humans in the evolutionary tree of life. Very short-lived species such as worms and flies allow for much cheaper, faster studies, but the biochemistry of these species is more distant from ours, meaning fewer of the results are relevant to human medicine. Fortunately many of the fundamental processes of aging are near universal in animal life, all the way down to yeast colonies, so it is possible to perform useful exploratory research at a reasonable price. Still, researchers are ever in search of a bett...
Source: Fight Aging! - August 25, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
ZERO TOLERANCE for hypoglycemia
Wheat elimination starts you powerfully on the path to reversing diabetes. We’ve seen it many times and it continues to develop in people who kiss their bagels, pretzels, and processed foods booby-trapped with wheat and grains goodbye.
But, as diabetics become less diabetic–a process that can occur VERY quickly, often within days of removing all wheat and grain products from their diet–but they are taking insulin or certain diabetes drugs, there is potential for hypoglycemia or low blood sugar. Low blood sugar from diabetes drugs can be dangerous and should be avoided at all costs. (Imagine if a non-diabetic started ...
Source: Wheat Belly Blog - April 2, 2016 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle diabetes glucose gluten grains hypoglycemia insulin Source Type: blogs
