Pharmacological strategies for sexual recovery in men undergoing antipsychotic treatment
This article reviews the literature on pharmacologic approaches for management strategies in men who are administered with antipsychotics and developed SD. The etiology of antipsychotic-induced SD is also discussed.EXPERT OPINION: Clinicians must consider sexual life as a major health domain. To do so, a first step would be to measure and monitor sexual function by means of psychometric tools. Secondly, primary prevention should be conducted when choosing antipsychotics, i.e. picking sex-sparing compounds like aripiprazole or brexpiprazole. Thirdly, if sexolytic compounds cannot be dismissed, such as first-generation antip...
Source: Expert Opinion on Pharmacotherapy - April 26, 2022 Category: Drugs & Pharmacology Authors: Tommaso B Jannini Andrea Sansone Rodolfo Rossi Giorgio Di Lorenzo Massimiliano Toscano Alberto Siracusano Emmanuele A Jannini Source Type: research

Impact of 3-Monthly Long-Acting Injectable Paliperidone Palmitate in Schizophrenia: A Retrospective, Real-World Analysis of Population-Based Health Records in Spain
ConclusionsPP3M was more effective than OAs and monthly LAIs in improving clinical outcomes for patients with schizophrenia in a real-world setting in Spain. (Source: CNS Drugs)
Source: CNS Drugs - April 23, 2022 Category: Neurology Source Type: research

Serotonergic drugs modulate the phase behavior of complex lipid bilayers
Biochimie. 2022 Apr 18:S0300-9084(22)00101-8. doi: 10.1016/j.biochi.2022.04.006. Online ahead of print.ABSTRACTSerotonin is an endogenous neurotransmitter involved in both physiological and pathophysiological processes. Traditionally, serotonin acts as a ligand for G protein-coupled receptors (GPCRs) leading to subsequent cell signaling. However, serotonin can also bind to lipid membranes with high affinity and modulate the phase behavior in 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine (POPC)/N-palmitoyl-D-erythro-sphingosylphosphorylcholine (PSM)/cholesterol model membranes mimicking the outer leaflet of the plasma membr...
Source: Biochimie - April 21, 2022 Category: Biochemistry Authors: Guzel Musabirova Oskar Engberg Ankur Gupta Debsankar Saha Roy Sudipta Maiti Daniel Huster Source Type: research

Serotonergic drugs modulate the phase behavior of complex lipid bilayers
Biochimie. 2022 Apr 18:S0300-9084(22)00101-8. doi: 10.1016/j.biochi.2022.04.006. Online ahead of print.ABSTRACTSerotonin is an endogenous neurotransmitter involved in both physiological and pathophysiological processes. Traditionally, serotonin acts as a ligand for G protein-coupled receptors (GPCRs) leading to subsequent cell signaling. However, serotonin can also bind to lipid membranes with high affinity and modulate the phase behavior in 1-palmitoyl-2-oleoyl-glycero-3-phosphocholine (POPC)/N-palmitoyl-D-erythro-sphingosylphosphorylcholine (PSM)/cholesterol model membranes mimicking the outer leaflet of the plasma membr...
Source: Biochimie - April 21, 2022 Category: Biochemistry Authors: Guzel Musabirova Oskar Engberg Ankur Gupta Debsankar Saha Roy Sudipta Maiti Daniel Huster Source Type: research

A case report of clozapine-treatment-resistant schizophrenia successfully managed with brexpiprazole combination therapy
Asian J Psychiatr. 2022 Apr 9;72:103121. doi: 10.1016/j.ajp.2022.103121. Online ahead of print.ABSTRACTClozapine-resistant schizophrenia (CRS) occurs in 40%- 70% of clozapine-treated schizophrenic patients. Hereby we describe a 20-year-old CRS subject with comorbid cannabinoid use disorder, successfully treated with clozapine-brexpiprazole combination, subsequently switched to clozapine plus long-acting injectable aripiprazole.PMID:35427934 | DOI:10.1016/j.ajp.2022.103121 (Source: Asian Journal of Psychiatry)
Source: Asian Journal of Psychiatry - April 15, 2022 Category: Psychiatry Authors: Laura Orsolini Silvia Bellagamba Virginio Salvi Umberto Volpe Source Type: research

Phase 3b Multicenter, Prospective, Open-label Trial to Evaluate the Effects of a Digital Medicine System on Inpatient Psychiatric Hospitalization Rates for Adults With Schizophrenia
Conclusions: Compared with oral SOC, AS reduced inpatient psychiatric hospitalization rates for adults with mild-to-moderate schizophrenia. The AS system may aid medication ingestion and is associated with improvements in symptoms, potentially reducing acute-care needs among patients with schizophrenia.Trial Registration: ClinicalTrials.gov identifier: NCT03892889.PMID:35421287 | DOI:10.4088/JCP.21m14132 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - April 14, 2022 Category: Psychiatry Authors: Elan A Cohen Taisa Skubiak Dusica Hadzi Boskovic Keinya Norman Jonathan Knights Hui Fang Antonia Coppin-Renz Timothy Peters-Strickland Jean-Pierre Lindenmayer J Corey Reuteman-Fowler Source Type: research