Case series on aripiprazole and dopamine supersensitivity psychosis
The objective of this article is to present four cases demonstrating rapid and dramatic onset of DSP during switching to aripiprazole. In each case, a patient with a Diagnostic and statistical manual of mental disorders (5th ed.) diagnosis of schizophrenia experienced severe worsening of psychosis within 4–5 days of abrupt switching to aripiprazole from a full D2 antagonist. To our knowledge, this is the first case series characterizing the previously well-documented worsening of psychosis during switching to aripiprazole specifically as aripiprazole-induced DSP. We discuss clinical relevance, prevention and future dir...
Source: International Clinical Psychopharmacology - April 13, 2022 Category: Psychiatry Tags: Case report Source Type: research

Orexin-a elevation in antipsychotic-treated compared to drug-free patients with schizophrenia: A medication effect independent of metabolic syndrome
CONCLUSION: With the inclusion of drug-free patients rather than healthy controls for comparison, we demonstrated that orexin-A is upregulated following APD treatment even after we controlled the potential effect from MS, suggesting an independent effect of APDs on orexin-A levels. Furthermore, the effect differed between APDs with dissimilar obesogenicity, i.e. less obesogenicity likely associated with higher orexin-A levels. Future prospective studies exploring the causal relationship between APDs treatment and orexin-A elevation as well as the underlying mechanisms are warranted.PMID:35396156 | DOI:10.1016/j.jfma.2022.0...
Source: J Formos Med Assoc - April 9, 2022 Category: General Medicine Authors: Po-Yu Chen Chin-Kuo Chang Chun-Hsin Chen Su-Chen Fang Valeria Mondelli Chih-Chiang Chiu Mong-Liang Lu Ling-Ling Hwang Ming-Chyi Huang Source Type: research

Orexin-a elevation in antipsychotic-treated compared to drug-free patients with schizophrenia: A medication effect independent of metabolic syndrome
CONCLUSION: With the inclusion of drug-free patients rather than healthy controls for comparison, we demonstrated that orexin-A is upregulated following APD treatment even after we controlled the potential effect from MS, suggesting an independent effect of APDs on orexin-A levels. Furthermore, the effect differed between APDs with dissimilar obesogenicity, i.e. less obesogenicity likely associated with higher orexin-A levels. Future prospective studies exploring the causal relationship between APDs treatment and orexin-A elevation as well as the underlying mechanisms are warranted.PMID:35396156 | DOI:10.1016/j.jfma.2022.0...
Source: J Formos Med Assoc - April 9, 2022 Category: General Medicine Authors: Po-Yu Chen Chin-Kuo Chang Chun-Hsin Chen Su-Chen Fang Valeria Mondelli Chih-Chiang Chiu Mong-Liang Lu Ling-Ling Hwang Ming-Chyi Huang Source Type: research

Predicting Medication Nonadherence in Older Adults With Difficult-to-Treat Depression in the IRL-GRey Randomized Controlled Trial
CONCLUSION: Future studies should consider the role of early response and cognitive function to improve antidepressant adherence, particularly among older adults who live alone.PMID:35393165 | DOI:10.1016/j.jagp.2022.03.002 (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - April 8, 2022 Category: Psychiatry Authors: Helene M Altmann Joseph Kazan Marie Anne Gebara Daniel M Blumberger Jordan F Karp Eric J Lenze Benoit H Mulsant Charles F Reynolds Sarah T Stahl Source Type: research

Predicting Medication Nonadherence in Older Adults With Difficult-to-Treat Depression in the IRL-GRey Randomized Controlled Trial
CONCLUSION: Future studies should consider the role of early response and cognitive function to improve antidepressant adherence, particularly among older adults who live alone.PMID:35393165 | DOI:10.1016/j.jagp.2022.03.002 (Source: Am J Geriatr Psychia...)
Source: Am J Geriatr Psychia... - April 8, 2022 Category: Geriatrics Authors: Helene M Altmann Joseph Kazan Marie Anne Gebara Daniel M Blumberger Jordan F Karp Eric J Lenze Benoit H Mulsant Charles F Reynolds Sarah T Stahl Source Type: research

Predicting Medication Nonadherence in Older Adults With Difficult-to-Treat Depression in the IRL-GRey Randomized Controlled Trial
CONCLUSION: Future studies should consider the role of early response and cognitive function to improve antidepressant adherence, particularly among older adults who live alone.PMID:35393165 | DOI:10.1016/j.jagp.2022.03.002 (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - April 8, 2022 Category: Psychiatry Authors: Helene M Altmann Joseph Kazan Marie Anne Gebara Daniel M Blumberger Jordan F Karp Eric J Lenze Benoit H Mulsant Charles F Reynolds Sarah T Stahl Source Type: research

Predicting Medication Nonadherence in Older Adults With Difficult-to-Treat Depression in the IRL-GRey Randomized Controlled Trial
CONCLUSION: Future studies should consider the role of early response and cognitive function to improve antidepressant adherence, particularly among older adults who live alone.PMID:35393165 | DOI:10.1016/j.jagp.2022.03.002 (Source: Am J Geriatr Psychia...)
Source: Am J Geriatr Psychia... - April 8, 2022 Category: Geriatrics Authors: Helene M Altmann Joseph Kazan Marie Anne Gebara Daniel M Blumberger Jordan F Karp Eric J Lenze Benoit H Mulsant Charles F Reynolds Sarah T Stahl Source Type: research

Predicting Medication Nonadherence in Older Adults With Difficult-to-Treat Depression in the IRL-GRey Randomized Controlled Trial
CONCLUSION: Future studies should consider the role of early response and cognitive function to improve antidepressant adherence, particularly among older adults who live alone.PMID:35393165 | DOI:10.1016/j.jagp.2022.03.002 (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - April 8, 2022 Category: Psychiatry Authors: Helene M Altmann Joseph Kazan Marie Anne Gebara Daniel M Blumberger Jordan F Karp Eric J Lenze Benoit H Mulsant Charles F Reynolds Sarah T Stahl Source Type: research

Predicting Medication Nonadherence in Older Adults With Difficult-to-Treat Depression in the IRL-GRey Randomized Controlled Trial
CONCLUSION: Future studies should consider the role of early response and cognitive function to improve antidepressant adherence, particularly among older adults who live alone.PMID:35393165 | DOI:10.1016/j.jagp.2022.03.002 (Source: Am J Geriatr Psychia...)
Source: Am J Geriatr Psychia... - April 8, 2022 Category: Geriatrics Authors: Helene M Altmann Joseph Kazan Marie Anne Gebara Daniel M Blumberger Jordan F Karp Eric J Lenze Benoit H Mulsant Charles F Reynolds Sarah T Stahl Source Type: research

Predicting Medication Nonadherence in Older Adults With Difficult-to-Treat Depression in the IRL-GRey Randomized Controlled Trial
CONCLUSION: Future studies should consider the role of early response and cognitive function to improve antidepressant adherence, particularly among older adults who live alone.PMID:35393165 | DOI:10.1016/j.jagp.2022.03.002 (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - April 8, 2022 Category: Psychiatry Authors: Helene M Altmann Joseph Kazan Marie Anne Gebara Daniel M Blumberger Jordan F Karp Eric J Lenze Benoit H Mulsant Charles F Reynolds Sarah T Stahl Source Type: research

Predicting Medication Nonadherence in Older Adults With Difficult-to-Treat Depression in the IRL-GRey Randomized Controlled Trial
CONCLUSION: Future studies should consider the role of early response and cognitive function to improve antidepressant adherence, particularly among older adults who live alone.PMID:35393165 | DOI:10.1016/j.jagp.2022.03.002 (Source: Am J Geriatr Psychia...)
Source: Am J Geriatr Psychia... - April 8, 2022 Category: Geriatrics Authors: Helene M Altmann Joseph Kazan Marie Anne Gebara Daniel M Blumberger Jordan F Karp Eric J Lenze Benoit H Mulsant Charles F Reynolds Sarah T Stahl Source Type: research

Predicting Medication Nonadherence in Older Adults With Difficult-to-Treat Depression in the IRL-GRey Randomized Controlled Trial
CONCLUSION: Future studies should consider the role of early response and cognitive function to improve antidepressant adherence, particularly among older adults who live alone.PMID:35393165 | DOI:10.1016/j.jagp.2022.03.002 (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - April 8, 2022 Category: Psychiatry Authors: Helene M Altmann Joseph Kazan Marie Anne Gebara Daniel M Blumberger Jordan F Karp Eric J Lenze Benoit H Mulsant Charles F Reynolds Sarah T Stahl Source Type: research