Aripiprazole-induced quasi-neuroleptic malignant syndrome: two case reports
ConclusionThough aripiprazole use is less likely to cause neuroleptic malignant syndrome, on rare occasions it can produce massive symptomatic or asymptomatic increase in serum creatine kinase enzyme levels, raising the need for close monitoring, especially at the initial doses of the drug. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - April 18, 2024 Category: General Medicine Source Type: research
Rapid Metabolism Underlying Subtherapeutic Serum Levels of Atypical Antipsychotics Preceding Clozapine Treatment: A Retrospective Analysis of Real-World Data
ConclusionLCD and associated rapid metabolism of non-clozapine antipsychotics is frequent before starting clozapine treatment. For olanzapine and quetiapine, this is associated with significantly increased risk of having subtherapeutic concentrations. (Source: CNS Drugs)
Source: CNS Drugs - April 18, 2024 Category: Neurology Source Type: research
Population Pharmacokinetics and Dosing Simulations for Aripiprazole 2 ‐Month Ready‐to‐Use Long‐Acting Injectable in Adult Patients With Schizophrenia or Bipolar I Disorder
AbstractA ready-to-use (RTU) long-acting injectable (LAI) formulation of aripiprazole monohydrate for administration once every 2 months, available in 960 mg (Ari 2MRTU 960) or 720 mg doses, has been developed for the treatment of schizophrenia or bipolar I disorder. A previously developed and validated population pharmacokinetic model for characterizing aripiprazole plasma concentrations following administration of oral aripiprazole or aripiprazole once-monthly (AOM) intramuscular injection was expanded to include the RTU LAI formulation of aripiprazole (Ari RTU LAI). Overall, 8899 aripiprazole pharmacokinetic samples f...
Source: Clinical Pharmacology in Drug Development - April 12, 2024 Category: Drugs & Pharmacology Authors: Yanlin Wang,
Matthew Harlin,
Frank Larsen,
Xiaofeng Wang,
Wansu Park,
Benjamin Rich,
Jogarao V. Gobburu,
Arash Raoufinia Tags: Original Article Source Type: research
Antipsychotic prescribing: national findings of children and adolescents attending mental health services in Ireland
We described the frequency of antipsychotic medication, medication type, target condition, target symptom and medication doses. We used multivariable logistic regression, adjusted with available co-variates to assess the association of being presc ribed an antipsychotic medication. Twelve percentage (n = 437) were prescribed an antipsychotic and 16–17-years (n = 211, 48.3%) was the most common age category. The commonest reason for prescribing an antipsychotic was target symptoms (i.e., off-label use) (n = 329; 75.%) and of thes e symptoms, agitation (n = 77/329; 25%) and irritability (56/239; 25%) were t...
Source: European Child and Adolescent Psychiatry - April 12, 2024 Category: Psychiatry Source Type: research
The First Smart Pill: Digital Revolution or Last Gasp?
Kennedy Inst Ethics J. 2023;33(3):277-319. doi: 10.1353/ken.2023.a917930.ABSTRACTAbilify MyCite was granted regulatory approval in 2017, becoming the world's first "smart pill" that could digitally track whether patients had taken their medication. The new technology was introduced as one that had gained the support of patients and ethicists alike, and could contribute to solving the widespread and costly problem of patient nonadherence. Here, we offer an in-depth exploration of this narrative, through an examination of the origins and development of Abilify, the drug that would later become MyCite. This history illuminate...
Source: Kennedy Institute of Ethics Journal - April 8, 2024 Category: Medical Ethics Authors: Anna K Swartz Phoebe Friesen Source Type: research
Long term online desalting analysis of MS/LC-MS using thermal assisted recrystallization ionization
In this study, a novel thermal assisted recrystallization ionization mass spectrometry (TARI-MS) device was developed to achieve efficient on-line desalting and prolonged analysis of saline samples. The core component of this device was a heated plate positioned between the electrospray unit and the MS inlet. The desalting mechanism was demonstrated as the spontaneous separation of target molecules from salts during the "crystallization" process. After optimization, the angle between the nebulizer and the heated plate was 45°; the distance between the front end of the heated plate and the MS inlet was 2 mm; the distance b...
Source: Talanta - April 7, 2024 Category: Chemistry Authors: Weiwei Chen Kailong Yuan Quan He Qing Li Jing Luo Fengjian Chu Huiwen Wang Hongru Feng Yuanjiang Pan Source Type: research
Long term online desalting analysis of MS/LC-MS using thermal assisted recrystallization ionization
In this study, a novel thermal assisted recrystallization ionization mass spectrometry (TARI-MS) device was developed to achieve efficient on-line desalting and prolonged analysis of saline samples. The core component of this device was a heated plate positioned between the electrospray unit and the MS inlet. The desalting mechanism was demonstrated as the spontaneous separation of target molecules from salts during the "crystallization" process. After optimization, the angle between the nebulizer and the heated plate was 45°; the distance between the front end of the heated plate and the MS inlet was 2 mm; the distance b...
Source: Talanta - April 7, 2024 Category: Chemistry Authors: Weiwei Chen Kailong Yuan Quan He Qing Li Jing Luo Fengjian Chu Huiwen Wang Hongru Feng Yuanjiang Pan Source Type: research
Hospitalized cocaine detoxification patients in Paris, France: Increased patient levels and changing population characteristics since 2011
CONCLUSION: The referral to hospital care for cocaine detoxification has increased in Paris region since 2011, coupled with changes in inpatients' characteristics. This trend has significant implications for the management of inpatient hospital services.PMID:38582619 | DOI:10.1016/j.therap.2024.03.001 (Source: Therapie)
Source: Therapie - April 6, 2024 Category: Psychiatry & Psychology Authors: Virgile Clergue-Duval Arthur Lyonnet Julien Azuar Romain Icick Margaux Poireau Dorian Rollet Namik Taright Frank Questel Isabelle Gasquet Florence Vorspan Source Type: research
