Prognosis of patients with bronchopulmonary neuroendocrine neoplasms in a tertiary NET Centre of Excellence

Introduction: The European Neuroendocrine Tumor Society, ENETS, reports variables of prognostic significance in bronchopulmonary neuroendocrine neoplasms. The aim of this study was to investigate prognostic factors, recurrence free survival (RFS) and overall survival (OS) for patients with typical carcinoid (TC), atypical carcinoid (AC) and large cell neuroendocrine carcinoma (LCNEC). Current follow-up practices vary as the evidence is sparse and we aimed to explore the relevance of routine bronchoscopy in follow-up. Methods: A cohort study of 208 patients with bronchopulmonary neuroendocrine neoplasms (BP-NENs) followed at Aarhus University Hospital in 2008-2019. Kaplan-Meier method for RFS and OS were determined for the variables: primary tumor, primary treatment, smoking status, gender and histological subtypes. Results: The study included 153 patients with TC, 29 with AC and 26 with LCNEC. Median follow-up was 48 months. The majority of patients (n = 191) received surgical resection, of which 22 (11%) recurred over time. Seventeen patients had non-surgical treatment, of which 10 (59%) progressed. The 5-year OS-rate were 86% for operated and 9% for non-operated patients (p
Source: Neuroendocrinology - Category: Endocrinology Source Type: research