Processing mechanism of guanidinoacetate in choroid plexus epithelial cells: conversion of guanidinoacetate to creatine via guanidinoacetate N-methyltransferase and monocarboxylate transporter 12-mediated creatine release into the CSF

ConclusionsIn CPxEpic, GAA is metabolized to creatine via GAMT. Biosynthesized creatine is then released into the CSF via MCT12 and supplied to the brain parenchyma.

http://link.springer.com/10.1186/s12987-022-00328-w

Source: Fluids and Barriers of the CNS - June 3, 2022 Category: Neuroscience Source Type: research