T-helper 17-related cytokines and IgE antibodies during hepatitis A virus infection in children.

T-helper 17-related cytokines and IgE antibodies during hepatitis A virus infection in children.
Mem Inst Oswaldo Cruz. 2015 Mar 31;:0
Authors: Trujillo-Ochoa JL, Corral-Jara KF, Escobedo-Meléndez G, Realpe M, Panduro A, Roman S, Fierro NA
Abstract
We determined the serum IgE levels and T-helper (Th)17-related cytokines during distinct hepatitis A virus (HAV)-induced clinical courses in children. A significantly higher concentration of macrophage inflammatory protein 3α, interleukin (IL)-17E and IL-17F in HAV-infected children with intermediate liver injury compared with those with minor liver damage was found. A reduction in the IgE levels in those patients who showed the highest levels of IL-17F in the group of intermediate liver injury was found. The data suggested that the Th17-related profile is associated with the severity of HAV infection and might play a role on the modulation achieved by HAV during allergies.
PMID: 25830544 [PubMed - as supplied by publisher]

Source: Memorias do Instituto Oswaldo Cruz - March 31, 2015 Category: Infectious Diseases Authors: Trujillo-Ochoa JL, Corral-Jara KF, Escobedo-Meléndez G, Realpe M, Panduro A, Roman S, Fierro NA Tags: Mem Inst Oswaldo Cruz Source Type: research