Cerebrolysin ® and Environmental Enrichment, Alone or in Combination, Ameliorate Anxiety- and Depressive-Like Behaviors in a Post-Ischemic Depression Model in Mice

Global cerebral ischemia (GCI) as a multi-dimensional disorder resulting from wide ranges of pathologic events including; asphyxia, arrhythmia, cardiac arrest as well as shock and affecting the entire brain.1,2 GCI increases reactive oxygen species (ROS) and cytokines and reduces brain-derived neurotrophic factor (BDNF), resulting in neuronal dysfunction in wide array of brain sites.3,4 Given the vulnerability of regions such as the hippocampus to the ischemic insults,5,6 GCI is commonly complicated by psychiatric disorders, the most common of which are post-ischemic depression (PID) and anxiety.

Source: Journal of Stroke and Cerebrovascular Diseases - April 29, 2022 Category: Neurology Authors: Fereshteh Farajdokht, Farnaz Oghbaei, Saeed Sadigh-Eteghad, Alireza Majdi, Sepideh Rahigh Aghsan, Mehdi Farhoudi, Nazila Vahidi-Eyrisofla, Javad Mahmoudi Source Type: research