Platelets are relevant mediators of renal injury induced by primary endothelial lesions.

In conclusion, platelets are relevant mediators of renal injury induced by primary endothelial lesions early on as demonstrated by platelet depletion as well as platelet inhibition via the P2Y12 receptor. While strategies to prevent platelet-endothelial interaction showed protective effects, platelets' contribution during renal regeneration remains unknown.
PMID: 25834071 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - April 1, 2015 Category: Urology & Nephrology Authors: Schwarzenberger C, Sradnick J, Lerea KM, Goligorsky MS, Nieswandt B, Hugo CP, Hohenstein B Tags: Am J Physiol Renal Physiol Source Type: research