Time series RNA-seq analysis identifies MAPK10 as a critical gene in diabetes mellitus-induced atrial fibrillation in mice

Atrial fibrillation (AF) is a major complication of type 2 diabetes mellitus (T2DM) and plays critical roles in the pathogenesis of atrial remodeling. However, the differentially expressed genes in atria during the development of AF induced by hyperglycemia have rarely been reported. Here, we showed time-dependent increased AF incidence and duration, atrial enlargement, inflammation, fibrosis, conduction time and action potential duration in db/db mice, a model of T2DM. RNA sequencing analysis showed that 2256 genes were differentially expressed in the atria at 12, 14 and 16  weeks.

Source: Journal of Molecular and Cellular Cardiology - April 27, 2022 Category: Cytology Authors: Fei Liu, Yawen Deng, Yong Zhao, Zhitong Li, Jinghan Gao, Yunlong Zhang, Xiaolei Yang, Yang Liu, Yunlong Xia Source Type: research