m6A RNA modifications: key regulators of normal and malignant hematopoiesis

Hematopoiesis is tightly controlled at transcriptional and post-transcriptional levels. Alterations to these regulatory mechanisms directly affect the function of hematopoietic stem cells (HSCs), which are responsible for life-long blood cell production and maintenance, and this often results in the development of hematological malignancies, including acute myeloid leukemia (AML) [1].

Source: Experimental Hematology - April 26, 2022 Category: Hematology Authors: Pia Sommerkamp, Jessie A. Brown, Myriam L.R. Haltalli, Fran çois E. Mercier, Ly P. Vu, Kamil R. Kranc Tags: Perspective Source Type: research