Cancers, Vol. 14, Pages 1970: A Mutated Prostatic Acid Phosphatase (PAP) Peptide-Based Vaccine Induces PAP-Specific CD8+ T Cells with Ex Vivo Cytotoxic Capacities in HHDII/DR1 Transgenic Mice

Conclusions: The periphery of patients with PCa exhibits immune responsiveness to the MutPAP42mer peptide and immunization of mice induces/expands T cell-driven, wild-type PAP immunity, and therefore, has the potential to drive protective anti-tumor immunity in patients with PCa.

Source: Cancers - April 13, 2022 Category: Cancer & Oncology Authors: Pauline Le Vu Jayakumar Vadakekolathu Sarra Idri Holly Nicholls Manon Cavaignac Stephen Reeder Masood A. Khan Dennis Christensen Alan Graham Pockley St éphanie E. McArdle Tags: Article Source Type: research