Experience of 6-l-[18F]FDOPA Production Using Commercial Disposable Cassettes and an Automated Module

ConclusionThe yields obtained are low and hence there is a need to improve synthetic chemistry. In order to understand the efficiency of each step, a detailed analysis using the radioactive traces obtained from the automated module was carried out. The radiolabeling yield of precursor is only about 50% and there is subsequent reduction in activity in the oxidation as well as hydrolysis steps. Despite the low radiochemical yields, the product obtained was suitable for imaging.
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research