Synthesis, structural characterization, and cytotoxic activity of new Benzo[d]imidazo[2,1-b]thiazole derivatives against MCF-7 breast cancer cells

This study is aimed to synthesize a new series of diaryl benzo[d]imidazo[2,1-b]thiazole compounds containing aminoethoxy side chain and in vitro investigation of their cytotoxicity on a human breast cancer cell line (MCF-7). Twelve derivates (6a-6l) were synthesized from this scaffold, which the structures were spectroscopically confirmed. Their cytotoxic effects on the MCF-7 cell line were also assessed using an MTT assay. All these compounds showed a good inhibitory effect on the MCF-7 cell line compared to that of tamoxifen. Among them, compounds (6i) and (6j) showed higher cytotoxicity with relevant inhibitory effects of 81 and 73%, respectively.
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research