Combination strategies to promote sensitivity to cytarabine-induced replication stress in acute myeloid leukemia with and without DNMT3A mutations

Acute myeloid leukemia (AML) is an aggressive malignancy of the blood system and the most common acute leukemia in adults (2,3). Improvements in chemotherapy combined with a limited number of targeted approaches thanks to better understanding of the disease mechanisms significantly extended survival in younger patients. Yet, the outcomes in advanced-age AML patients (65 and older, constituting more than half of all cases) remain dismal. Although studies demonstrated survival benefit of induction chemotherapy dose intensification (4,5), most patients are unable to tolerate aggressive treatment due to comorbidities and frailty (3,6).

Source: Experimental Hematology - March 16, 2022 Category: Hematology Authors: Daniil E Shabashvili, Yang Feng, Prabhjot Kaur, Kartika Venugopal, Olga A Guryanova Source Type: research