Associations between age of menarche and genetic variation in women of African descent: genome-wide association study and polygenic score analysis

This study suggests that in women of African ancestry the genetic drivers of age at menarche may differ from those identified in populations of non-African ancestry, and that these differences are more pronounced in women living in Nigeria, although some associated trait loci may be shared across populations. This highlights the need for well-powered ancestry-specific genetic studies to fully characterise the genetic influences of age at menarche.

Source: Journal of Epidemiology and Community Health - March 10, 2022 Category: Epidemiology Authors: Scannell Bryan, M., Ogundiran, T., Ojengbede, O., Zheng, W., Blot, W., Domcheck, S., Hennis, A., Nemesure, B., Ambs, S., Olopade, O. I., Huo, D. Tags: Original research Source Type: research